A5029998861- Pharmacological Effects of Natural Compounds
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- X-ray Diffraction in Crystallography
- Microscopic Colitis
- Antimicrobial Peptides and Activities
- Cancer therapeutics and mechanisms
- Carbohydrate Chemistry and Synthesis
- Antibiotics Pharmacokinetics and Efficacy
- Crystallization and Solubility Studies
University of Notre Dame
2018-2023
Notre Dame of Dadiangas University
2018
Abstract Lytic transglycosylases (LTs) catalyze the non-hydrolytic cleavage of bacterial cell wall by an intramolecular transacetalization reaction. This reaction is critically and broadly important in modifications course its biosynthesis, recycling, manifestation virulence, insertion structural entities such as flagellum pili, among others. The first QM/MM analysis mechanism LT, that for Escherichia coli MltE, undertaken. study reveals a conformational itinerary consistent with...
Clostridioides difficile infection (CDI) is the most lethal of five CDC urgent public health treats, resulting in 12,800 annual deaths United States alone [Antibiotic Resistance Threats States, 2019 (2019), www.cdc.gov/DrugResistance/Biggest-Threats.html]. The high recurrence rate and inability antibiotics to treat such infections mandate discovery new therapeutics. A major challenge with CDI production spores, leading multiple recurrences 25% patients [C. P. Kelly, J. T. LaMont, N. Engl....
β-Lactams are used routinely to treat Staphylococcus aureus infections. However, the emergence of methicillin-resistant S. (MRSA) renders them clinically precarious. We describe a class cinnamonitrile adjuvants that restore activity oxacillin (a penicillin member β-lactams) against MRSA. The lead were tested six important strains MRSA, one vancomycin-intermediate (VISA) strain, and linezolid-resistant strain. Five compounds out 84 total showed broad potentiation. At 8 μM...
A major challenge for chemotherapy of bacterial infections is perturbation the intestinal microbiota. Clostridioides difficile a Gram-positive bacterium gut that can thrive under this circumstance. Its production dormant and antibiotic-impervious spores results in chronic disruption normal flora debilitating diarrhea infection. C. responsible 12,800 deaths per year United States. Here, we report discovery 2-(4-(3-(trifluoromethoxy)phenoxy)picolinamido)benzo[d]oxazole-5-carboxylate as an...
MIC of oxacillin against <italic>S. aureus</italic> (MRSA252 strain) reduced from 256 μg mL<sup>−1</sup> to 2 mL<sup>−1</sup>.
Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficult to eradicate due its ability form spores, which are not susceptible To address the urgent need for treating recurrent infection, antibiotics that selectively target over common needed. We herein describe class picolinamide antibacterials show potent and selective activity against difficile. The...