A5082037054- Vestibular and auditory disorders
- Glaucoma and retinal disorders
- Ophthalmology and Eye Disorders
- Cerebral Venous Sinus Thrombosis
- Facial Nerve Paralysis Treatment and Research
- Peripheral Neuropathies and Disorders
- Glioma Diagnosis and Treatment
- Genetic Neurodegenerative Diseases
- Otitis Media and Relapsing Polychondritis
- Generative Adversarial Networks and Image Synthesis
- Autoimmune Neurological Disorders and Treatments
- IgG4-Related and Inflammatory Diseases
- Advanced Image and Video Retrieval Techniques
- Ophthalmology and Visual Health Research
- Neurofibromatosis and Schwannoma Cases
- Multimodal Machine Learning Applications
- Retinal and Optic Conditions
- Balance, Gait, and Falls Prevention
- Virtual Reality Applications and Impacts
- Myasthenia Gravis and Thymoma
- Brain Metastases and Treatment
- Spinal Cord Injury Research
- Blood disorders and treatments
- Ear and Head Tumors
- Vasculitis and related conditions
Johns Hopkins Medicine
2021-2025
Johns Hopkins Hospital
2020-2025
Johns Hopkins University
2020-2025
Neurology, Inc
2025
University of California, Berkeley
2020
University of Toledo
2019
Michigan State University
2017-2019
Annually, several million patients in the United States visit emergency room (ER) with symptoms of vertigo or dizziness. Rapidly distinguishing between benign causes, such as inner ear disease, and more severe conditions, like strokes, necessitates performing interpreting a three-step bedside head eye movement assessment called HINTS (head impulse, nystagmus, test skew). This is accurate than state-of-the-art brain imaging, especially early disease's course when there limited window for...
Abstract Eye movements, such as nystagmus, saccades, and smooth pursuit, provide valuable information about neurological function but have limited publicly accessible datasets due to patient privacy concerns. To address this, we leverage generative AI create realistic videos of artificial eye movement, eliminating the need for real data. These synthetic shown performance comparable actual data in clinical tasks. Our generated will be openly shared, facilitating broader research advancement...
Spontaneous vertical eye movements in the critical care setting are often a source of confusion and alarm; while their origin remains at least partly theoretical, understanding classification associated clinical implications can inform diagnostic workup further management. This case describes patient who demonstrated ocular dipping: slow conjugate downward with quick return to primary gaze. Ocular dipping is rare phenomenon that was initially described patients hypoxic brain injury has since...
Patients with acute vestibular disorders are often a diagnostic challenge for neurologists, especially when the evaluation must be conducted remotely. The clinical dilemma remains: Does patient have benign peripheral inner ear problem or worrisome central disorder, such as stroke? use of focused history and virtual HINTS (head impulse test, nystagmus evaluation, test skew) examination key steps towards correctly diagnosing triaging vertiginous patient. When looking signs vestibulo-ocular...
Background Nystagmus identification and interpretation is challenging for non-experts who lack specific training in neuro-ophthalmology or neuro-otology. This challenge magnified when the task performed via telemedicine. Deep learning models have not been heavily studied video-based eye movement detection. Methods We developed, trained, validated a deep-learning system (aEYE) to classify video recordings as normal bearing at least two consecutive beats of nystagmus. The videos were...
We introduce a method that allows to automatically segment images into semantically meaningful regions without human supervision. Derived are consistent across different and coincide with human-defined semantic classes on some datasets. In cases where might be hard for define consistently label, our is still able find classes. work, we use pretrained StyleGAN2 generative model: clustering in the feature space of model discover Once discovered, synthetic dataset generated corresponding...
This study aims to enhance workup for dizziness/vertigo by translating advances in virtual reality (VR) and augmented (AR) eye tracking clinical practice.
This study seeks to improve the clinical care for myasthenia gravis by translating advances in eye tracking technology practice.
ABSTRACT The control of torsional eye position is a key component ocular motor function. Ocular torsion can be affected by pathologies that involve pathways, spanning from the vestibular labyrinth inner ears to various regions brainstem and cerebellum. Timely accurate diagnosis enables efficient interventions management each case which are crucial for patients with dizziness, vertical double vision, or imbalance. Such detailed evaluation movements may not possible in all frontline clinical...
An ocular tilt reaction (OTR) is a triad of skew deviation, head tilt, and counter-roll that can be partial or complete. OTR occur anywhere along the utriculo-ocular motor pathways from labyrinth to interstitial nucleus Cajal but almost always central in origin. In acute vestibular neuritis (AVN), case reports have described patients with an due AVN, although it unclear whether this examination finding common rare.The features 7 presenting AVN are described.Each presented typical including...
We describe a case with torsional deviation of the eyes from brainstem lesion. Torsional eye movement refers to changes in position roll plane around visual axis. When head is tilted laterally (that is, rolled toward shoulder), opposite direction as part vestibulo-ocular reflex known ocular counter-roll. Pathologies that affect otolith-ocular pathway can lead tilt reaction (OTR) also causes vertical (skew deviation) and tilt. Lesions caudal pontomedullary junction (such labyrinth, eighth...
The objective of the study is to develop deep learning models using synthetic fundus images assess direction (intorsion versus extorsion) and amount (physiologic pathologic) static ocular torsion. Static torsion assessment an important clinical tool for classifying vertical misalignment; however, current methods are time-intensive with steep curves frontline providers.
Abstract: A 62-year-old woman developed a right horizontal gaze palsy and ipsilateral facial nerve due to pontine tegmentum infarct. This constitutes forme fruste of the eight-and-a-half syndrome that we have termed eight syndrome.
A 62-year-old man with a history of metastatic squamous cell carcinoma (SCC) the scalp, who recently completed 5 cycles pembrolizumab, presented to emergency department 2 weeks progressive gait ataxia, dysarthria, dysphagia, and diplopia. On physical examination, he had profound areflexia, lower-extremity facial diplegia, ophthalmoplegia. Brain MRI was normal. Lumbar puncture showed albuminocytologic dissociation 7 white blood cells/µL protein 236 mg/dL (normal: 15–45 mg/dL). Additional...
A healthy 44-year-old woman developed malaise and severe headache shortly after returning from vacation in Hawaii. As initial symptoms cleared 24 hours, over the subsequent days, she paresthesias her lower extremities (knees to feet), new-onset urinary retention, midthoracic radicular pain. Brain MRI revealed nonenhancing lesions medulla midbrain, addition punctate subcortical frontal (figure). of cervical spine 2 at C3-C4 C6-C7 She was diagnosed with MS contemplated disease-modifying therapy (DMT).
A 71-year-old man presented with acute dizziness and right-sided paresthesia. Examination revealed spontaneous torsional nystagmus (top pole of eyes beating to the left) a milder upbeat component (Video 1), weakness, right hemisensory loss. MRI brain showed an left medial medullary infarct (Figure). Spontaneous upbeat-torsional typically results from selective damage vertical semicircular canal pathways in longitudinal fasciculus (MLF), often resulting ipsilesional-beating nystagmus.1 It is...
Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The illustrates value remaining vigilant for possibility paraneoplastic syndromes in context anti-GAD65 antibodies thymoma. It also that tumor-directed therapies may offer additional benefit beyond therapy alone.