A5043911574- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- biodegradable polymer synthesis and properties
- Wound Healing and Treatments
- Curcumin's Biomedical Applications
- Antifungal resistance and susceptibility
- Silk-based biomaterials and applications
- Dermatology and Skin Diseases
- Ocular Infections and Treatments
- Photodynamic Therapy Research Studies
- Science and Education Research
- Antimicrobial agents and applications
- Planarian Biology and Electrostimulation
- Proteins in Food Systems
- Bacterial biofilms and quorum sensing
- Nanocomposite Films for Food Packaging
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Fungal Infections and Studies
- Biochemical and biochemical processes
- Toxin Mechanisms and Immunotoxins
- Laser Applications in Dentistry and Medicine
- Metal complexes synthesis and properties
Universidade de São Paulo
2015-2024
Hospital Universitário da Universidade de São Paulo
2020-2022
Clinics Hospital of Ribeirão Preto
2020
Universidade Estadual do Centro-Oeste
2012-2016
Universidade Estadual de Ponta Grossa
2016
Abstract Topical ophthalmic antibiotics show low efficacy due to the well-known physiological defense mechanisms of eye, which prevents penetration exogenous substances. Here, we aimed incorporate besifloxacin into liposomes containing amines as positively charged additives and evaluate influence this charge on drug delivery in two situations: (i) iontophoretic (ii) passive treatments. Hypothesis are might enhance electromigration component upon current application improving efficiency for a...
In this study, poly(L-lactide) (PLA) nanoparticles containing amphotericin B (AmB) were developed, and the in vitro cytotoxicity to human erythrocytes efficacy on strains of Candida spp. evaluated. The prepared using an emulsion/solvent evaporation method characterized with respect size, size distribution, AmB encapsulation efficiency, state aggregation, release profile. mean particle was 225 nm, efficiency over 69%. profile revealed a burst effect within first 24 h, which released...
Lipophilic drugs do not usually benefit from iontophoresis mainly because they solubilize in aqueous formulations suitable for the application of electric current. To explore influence on penetration these drugs, a cationic nanoemulsion was developed to zinc phthalocyanine (ZnPc), promising drug treatment skin cancer. verify particle size iontophoresis, an emulsion nanoemulsion-like composition also developed. The were characterized and cutaneous tumor studies performed vitro vivo,...
In this paper, a rapid and effective chromatographic procedure for determining the curcumin encapsulation efficiency in poly(lactic-co-glycolic acid) (PLGA) acid)-polyethyleneglycol (PLGA-PEG) nanoparticles via reversed-phase high-performance liquid chromatography (RP-HPLC) using fluorescence detector low flow rate is described. Chromatographic runs were performed on RP C18 column (250 mm x 4.6 mm, 5 μm) with mixture of ethanol, water acetonitrile (80:10:10, v/v/v) as mobile phase 0.8 mL/min...
Atopic dermatitis (AD) is a chronic inflammatory skin disease that difficult to treat. Traditional cold cream, water-in-oil emulsion made from beeswax, used alleviate AD symptoms in clinical practice, although its effectiveness has not been scientifically proven. The addition of propolis the potential impart anti-inflammatory properties cream. However, high concentrations, can trigger allergic reactions. Thus, objective this work was develop cream formulation based on purified beeswax...
Polymeric nanoparticles are colloidal systems that promote protection and modification of physicochemical characteristics a drug also ensure controlled extended release. This paper reports 2(3) factorial design study to optimize poly(lactide) (PLA) poly(lactide)-polyethylene glycol (PLA-PEG) blend containing resveratrol (RVT) for prolonged The independent variables analyzed were solvent composition, surfactant concentration ratio aqueous organic phase (two levels each factor). Mean particle...
In this study, we developed poly(lactide)-poly(ethylene glycol) (PLA-PEG) blend nanoparticles with variable molecular PEG weights (2, 10, or 20 kDa) to encapsulate antifungal amphotericin B (AmB) and evaluate its in vitro efficacy strains of Candida sp. cytotoxicity human erythrocytes. The were prepared using an emulsification/solvent evaporation technique characterized respect size, size distribution, AmB entrapment efficiency, state aggregation, release profile. mean particle was 241 nm,...
The encapsulation process of the Pd<sup>II</sup> complex [PdCl(PPh<sub>3</sub>)(PrCh)], a promising cytotoxic agent on ovarian cancer cells, in PLGA polymer was studied. cytotoxicity results showed that formulation led to significant reduction cell viability (80% at 1 μM).
Iontophoresis, a non-invasive application of constant low-intensity electric current, is promising strategy to accelerate wound healing. Although its mechanisms are not yet fully elucidated, part action seems related inhibiting bacteria growth. This work aimed investigate the antimicrobial effect iontophoresis using Staphylococcus epidermidis and Escherichia coli strains, Gram-positive Gram-negative cells, respectively. Anodic was applied each bacterial cell suspension Ag/AgCl electrodes,...
Em busca de adjuvantes nova geração para uso na formulação vacinas contra patógenos virais, o trabalho teve como objetivo preparar nanopartículas quitosana encapsular VBI. Foi utilizado uma suspensão da estirpe H120 atenuada do VBI em líquido córion-alantóide (LCA) a das por meio técnica gelificação iônica. Foram testadas diferentes concentrações quitosana, ácido acético e tripolifosfato sódio (TPP) condições pH. Para preparo nanopartículas, um volume viral LCA foi adicionado 10 volumes...