A5052800931- Asymmetric Hydrogenation and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Catalytic Cross-Coupling Reactions
- Organoboron and organosilicon chemistry
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
- Analytical Chemistry and Chromatography
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Characterization
- Organometallic Compounds Synthesis and Characterization
- Nanomaterials for catalytic reactions
- Organometallic Complex Synthesis and Catalysis
- Coordination Chemistry and Organometallics
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Crystal structures of chemical compounds
- Microwave-Assisted Synthesis and Applications
- Trypanosoma species research and implications
- Boron Compounds in Chemistry
- Synthesis and pharmacology of benzodiazepine derivatives
- Advanced Synthetic Organic Chemistry
- Receptor Mechanisms and Signaling
University of Rostock
2002-2010
Leibniz Institute for Catalysis
2007-2010
University of Iowa
2006-2010
Leibniz Institute for Neurobiology
2007
University of Kentucky
2006
National Chemical Laboratory
2000-2004
Reductions under iron rule: Enantioselective hydrosilylation of prochiral ketones with inexpensive and environmentally benign catalysts proceed smoothly in the presence (S,S)-Me-duphos (see scheme; (S,S)-Me-duphos=1,2-(bis[(2S,5S)]-2,5-dimethylphospholano)benzene). A broad range aryl is converted into corresponding secondary alcohols up to 99 % enantioselectivity quantitative yields.
The iron-catalyzed reduction of aromatic nitro compounds to the corresponding anilines applying organosilanes is reported. In presence FeX(2)-R(3)P catalysts a series nitroarenes selectively reduced tolerating wide range functional groups.
A practical synthesis of a novel class phosphine ligands, phosphino substituted N-aryl pyrroles (PAP ligands), has been developed. These ligands are applied in the palladium-catalyzed coupling variety aryl and heteroaryl chlorides with phenylboronic acid showing exceedingly high turnover numbers at mild reaction temperatures even room temperature.
A general and highly chemoselective hydrosilylation of aldehydes using iron catalysts is reported. Fe(OAc)2 in the presence tricyclohexylphosphine as ligand polymethylhydrosiloxane (PMHS) an economical hydride source forms efficient catalyst system for a variety aldehydes. Aryl, heteroaryl, alkyl α,β-unsaturated are successfully reduced to corresponding primary alcohols. Broad substrate scope high tolerance against several functional groups make process synthetically useful.
Chloroalkanes refined: A simple catalyst system renders the palladium-catalyzed coupling reaction of functionalized alkyl chlorides and Grignard reagents at room temperature (see example in scheme; PCy3=tricyclohexylphosphane, NMP=N-methylpyrrolidinone).
Abstract The reduction of ketones with polymethylhydrosiloxane (PMHS) gives the corresponding alcohols in good to excellent yield applying iron‐based catalyst systems. In case prochiral ketones, use Fe(OAc) 2 /( S,S )‐Me‐DuPhos leads high enantioselectivity up 99 % ee . reaction proceeds presence several functional groups such as esters, halides well conjugated double bonds, chemoselectivity. advantage this protocol is that requires no activating agents or additives.
Abstract Studies of xenobiotic disposition in rodents often employ experimental designs using differing routes administration. In an effort to investigate the effects route administration on enantioselective xenobiotics, a chiral polychlorinated biphenyl (PCB), racemic PCB 136, was administered as single dose (50 mg/kg body weight) male or female C57BL/6 mice either orally via intraperitoneal injection. Mice were sacrificed after 3 6 days, and blood organs collected for analysis....
Abstract Iron catalyzed organic synthesis has emerged as a sustainable chemistry due to the highly competitive cost, high natural abundance and ecologically acceptable properties of iron. Moreover, its extensive range oxidation states i. e. –II +VI provides numerous opportunities perform multiple reactions. Recently iron catalysis started competing established precious metals. Among scaffolds, amines are important building blocks that useful in various fields starting from drugs, crop...
Chloralkane veredelt: Mit einfachen Katalysatorsystemen gelingt bereits bei Raumtemperatur die Palladium-katalysierte Kupplung von funktionalisierten Alkylchloriden mit Aryl-Grignard-Reagentien (siehe Beispiel in Schema; PCy3=Tricyclohexylphosphan, NMP=N-Methylpyrrolidinon).
Several iodobenzenes form tetraarylstannanes, in addition to other products, under reaction conditions typically employed for the Ullmann reaction, i.e., activated copper bronze (a copper−tin alloy) and 7 days at 230 °C. The isolated yields of tetraarylstannanes were low good (8−58%). Significantly higher (54−64%) tetraphenylstannane obtained by direct iodobenzene with an excess tin powder (iodobenzene:tin = 1:1 w/w) same conditions. Crystal structure analysis reveals that...
A simple and environmentally safe procedure for the preparation of 2-(o-aminophenyl)oxazolines from isatoic anhydride is presented. series chiral derivatives title compound prepared in moderate yield via natural kaolinitic clay catalyzed reactions with optically pure 2-aminoalcohols. Reaction polymer-supported under these conditions 2-aminoalcohols proceeds to furnish polymer-anchored analogues.
Carboxylic acids are regenerated from their corresponding substituted allyl esters by Montmorillonite K-10 using microwave irradiation under solvent free conditions to afford enhanced yields and reduced reaction times compared thermal conditions.
Abstract A new, convenient and sustainable protocol for the aldol condensation of chroman‐4‐one derivatives with aldehydes using iron as a catalyst under microwave irradiation in presence green solvent (2‐methyl‐THF) is presented. The offers very simple, cost efficient environmentally benign procedure good to excellent yields 3‐benzylidene‐4‐chromanone derivatives. methodology demonstrated be useful synthesis homoisoflavanoids Boundecullin, Sappanone their present method potential generate...
A simple method is described for the preparation of 1,3-dihydrofuro[4,3-b]quinolin-3-ol starting from aniline and methyl acetoacetate using selenium dioxide.