A5052562353- Neuroinflammation and Neurodegeneration Mechanisms
- Alcohol Consumption and Health Effects
- Traumatic Brain Injury and Neurovascular Disturbances
- Alcoholism and Thiamine Deficiency
- Acute Ischemic Stroke Management
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
Cyceron
2020-2022
Inserm
2020-2022
Physiopathologie et imagerie des troubles neurologiques
2020-2022
Université de Caen Normandie
2021-2022
Normandie Université
2020-2022
Despite an apparently silent imaging, some patients with mild traumatic brain injury (TBI) experience cognitive dysfunctions, which may persist chronically. Brain changes responsible for these dysfunctions are unclear and commonly overlooked. It is thus crucial to increase our understanding of the mechanisms linking initial event functional deficits, provide objective evidence tissue alterations underpinning deficits. We first set up a murine model closed-head controlled cortical impact,...
Alcohol abuse is a major public health problem worldwide, causing wide range of preventable morbidity and mortality. In this translational study, we show that heavy drinking (HD) (≥6 standard drinks/day) independently associated with worse outcome for ischemic stroke patients. To study the underlying mechanisms deleterious effect HD, performed an extensive analysis brain inflammatory responses mice chronically exposed or not to 10% alcohol before after stroke. Inflammatory were analyzed at...
Abstract Brain abnormalities observed in alcohol use disorder are highly heterogeneous nature and severity, possibly because chronic consumption also affects peripheral organs leading to comorbidities that can result exacerbated brain alterations. Despite numerous studies focussing on the effects of or liver, few have simultaneously examined liver function damage disorder, even fewer investigated relationship between them except hepatic encephalopathy. And yet, dysfunction may be a risk...