A5059444911- Infant Development and Preterm Care
- Infant Health and Development
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Music Therapy and Health
- Neuroscience and Music Perception
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Genomics and Rare Diseases
- Diverse Music Education Insights
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Language Development and Disorders
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Family and Patient Care in Intensive Care Units
- Photoreceptor and optogenetics research
University Hospital of Geneva
2019-2024
University of Geneva
2019-2024
University of Lisbon
2020
Hospital de Santa Maria
2018
Prematurity disrupts brain maturation by exposing the developing to different noxious stimuli present in neonatal intensive care unit (NICU) and depriving it from meaningful sensory inputs during a critical period of development, leading later neurodevelopmental impairments. Musicotherapy NICU environment has been proposed promote stimulation, relevant for activity-dependent plasticity, but its impact on structural is unknown. Neuroimaging studies have demonstrated that music listening...
Prematurity disrupts brain development during a critical period of growth and organization is known to be associated with an increased risk neurodevelopmental impairments. Investigating whole-brain structural connectivity alterations accompanying preterm birth may provide better comprehension the neurobiological mechanisms related later neurocognitive deficits observed in this population. Using connectome approach, we aimed study impact prematurity on neonatal network at term-equivalent age....
Abstract Music is known to induce emotions and activate associated memories, including musical memories. In adults, it well that music activates both working memory limbic networks. We have recently discovered as early during the newborn period, familiar processed differently from unfamiliar music. The present study evaluates listening effects at brain level in newborns, by exploring impact of or first‐time on subsequent resting‐state functional connectivity brain. Using a connectome‐based...
The main aim of the present study was to investigate effects COVID-19 pandemic on mothers’ postnatal depression, stress, and attachment during their stay in Neonatal Intensive Care Unit (NICU). Twenty mothers very premature infants born before 32weeks gestational age were recruited at Geneva University Hospital between January 2018 February 2020 started. Mothers screened for depression after preterm infant’s birth (Edinburgh Postnatal Depression Scale, EPDS), then stress (Parental Stressor...
Preterm birth disrupts important neurodevelopmental processes occurring from mid-fetal to term-age. Musicotherapy, by enriching infants' sensory input, might enhance brain maturation during this critical period of activity-dependent plasticity. To study the impact music on preterm structural changes, we recruited 54 very infants randomized receive or not a daily intervention, that have undergone longitudinal multi-shell diffusion MRI acquisition, before intervention (at 33 weeks' gestational...
Abstract Music is ubiquitous, both in its instrumental and vocal forms. While speech perception at birth has been the core of an extensive corpus research, origins ability to discriminate or melodies still not well investigated. In previous studies comparing musical perception, stimuli were mainly related speaking, including language, non‐language singing voice. present study, better compare a melodic line with voice, we used as comparison stimulus, reduce dissimilarities between two much...
Background Few studies have found long-term effects of early musical environmental enrichment in the NICU on preterm infant’s development. This study examines how music affects emotional development and effortful control abilities 12- 24-month-old very (VPT) infants. Methods One hundred nineteen newborns were recruited, including 83 VPTs 36 full-term (FT) The VPT infants randomly assigned to intervention (44 VPT-Music) or (39 VPT-control) groups. VPT-Music listened specifically designed from...
Abstract Background and Purpose Super‐resolutionreconstruction (SRR) can be used to reconstruct 3‐dimensional (3D) high‐resolution (HR) volume from several 2‐dimensional (2D) low‐resolution (LR) stacks of MRI slices. The purpose is compare lengthy 2D T2‐weighted HR image acquisition neonatal subjects with 3D SRR LR in terms quality for clinical morphometric assessments. Methods brain images were acquired isotropic volumes by using algorithm. Quality assessments done an experienced pediatric...
Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, also neurodegenerative neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase microglia affects hippocampal under inflammatory The results show long-term potentiation (LTP) magnitude recorded from slices wild type mice does not differ between those exposed to lipopolysaccharide (LPS), a pro-inflammatory stimulus, or BSA. However, LTP...
SCN2A mutations have been associated with a wide phenotypic spectrum that includes, among others, developmental and epileptic encephalopathy (DEE), usually not any brain structural counterpart. We report the occurrence of super-refractory status epilepticus (SRSE) in 2-month-old infant, who presented at birth refractory neonatal seizures attributed to an extensive bilateral polymicrogyria cortical dysplasia. Upon his SRSE, he responded radically sodium-channel blocker phenytoin complete...
Premature birth affects brain maturation, illustrated by altered functional connectivity at term equivalent age (TEA) and alters neurobehavioral outcome. To correct early developmental differences improve neurological outcome, music during the neonatal intensive care unit (NICU) stay has been proposed as an auditory enrichment with modulatory effects on structural development, but longitudinal of such interventions have not studied so far. We longitudinally investigated resting-state (RS-FC)...
Motivation: BOLD signal variability (BOLD-SD) has emerged as a measure for assessing brain function, but little is known regarding its biological significance. Goal(s): Demonstrate that cortical BOLD-SD modifications are accompanied by structural intracortical maturational changes. Elucidate networks undergoing the most important changes during early development. Approach: Longitudinal MRI acquisition in preterm infants at 33 and 40 weeks’ gestational age. Assessment of NODDI...
Motivation: Instrumental music and singing differ due to the vocal component of sung melody present distinct neural processing pathways, though its developmental origins remain unclear. Goal(s): This study explores early development vs brain processing. Approach: Dynamic PPI-CAPs approach was applied longitudinal fMRI data preterm infants at 33- 40-weeks gestational age. Results: Singing elicited a stronger activation salience language-related networks, while limbic networks. Default-mode...
Resting-state functional connectivity based on simultaneous BOLD oscillations has been described both in preterm infants and fullterm newborns. During this period of rapid cerebral cortex development, different brain activity patterns (networks) have previously described. Regional changes spontaneous signal variability the other hand reflect local intravoxel related to neural excitability/flexibility. In present study, we aimed explore longitudinal evolution between birth term-equivalent-age...