A5019390110- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Schizophrenia research and treatment
- Treatment of Major Depression
- Cytokine Signaling Pathways and Interactions
- Alcoholism and Thiamine Deficiency
- Dementia and Cognitive Impairment Research
- Urticaria and Related Conditions
- Intensive Care Unit Cognitive Disorders
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Drug Transport and Resistance Mechanisms
- Intestinal and Peritoneal Adhesions
- Posttraumatic Stress Disorder Research
- Cholinesterase and Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Enhanced Recovery After Surgery
- Anesthesia and Pain Management
- Biochemical effects in animals
- Personality Disorders and Psychopathology
- Colorectal and Anal Carcinomas
- Family Caregiving in Mental Illness
- Head and Neck Surgical Oncology
- Botulinum Toxin and Related Neurological Disorders
National Center for Advancing Translational Sciences
2023
Crescent University
2019
University of Edinburgh
2019
Chillicothe VA Medical Center
2013-2017
University of Virginia
2010-2014
Ohio University Chillicothe
2012-2013
University of Cincinnati
2007
Townsville Hospital
1999
Johns Hopkins University
1998
NYU Langone Health
1998
The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TBARS) assay, a measure of lipid peroxidation, followed determination activities antioxidant enzymes Cu/Zn superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), frontal, temporal, cerebellar cortex 10 AD 9 control brains. level TBARS elevated all regions, particular...
Schizophrenia and bipolar disorder are severe debilitating psychiatric disorders. Despite the availability of numerous antipsychotic drugs, many patients still experience poor outcomes treatment-limiting adverse side effects. Cariprazine is a novel with unique pharmacodynamic pharmacokinetic properties. It both dopamine type 2 3 partial agonist equipotent metabolites, desmethyl cariprazine didesmethyl cariprazine, which has half-life 1 to weeks. The objective this article review literature...
Abstract Introduction Neuropathy is a pathological pain disorder characterized by burning, stabbing, and cramping sensations. There are multiple etiologies for this such as diabetes, vascular disorders, chemotherapy treatment. Neurotransmitters, norepinephrine serotonin, thought to play part in the modulation of pain. The objective review summarize current literature support efficacy impact adverse events various classes antidepressants utilized treatment neuropathic Methods A Medline/Pubmed...
We report a case of delayed pneumothorax, central venous catheter migration and iatrogenic hydrothorax in 22‐year‐old female. The left subclavian initially transfixed the lung apex; pneumothorax occurred 24 h later following initiation positive pressure ventilation. Lung collapse as result caused hydrothorax. Catheter removal chest drainage led to an uneventful recovery.
A personality disorder is a pervasive and enduring pattern of behaviors that impacts an individual's social, occupational, overall functioning. Specifically, the cluster disorders include paranoid disorder, schizoid schizotypal disorder. Patients with tend to be isolative avoid relationships. The quality life may also reduced in these individuals, which provokes question how treat patients disorders. purpose this review evaluate current literature for pharmacologic treatments disorders.A...
This retrospective cohort study evaluated effects of buprenorphine/naloxone dose and concomitant use selected sedating medications on treatment outcomes in patients with opioid disorder.Patients enrolled the clinic at institution from 2009 until April 2013 were included. There no exclusion criteria. Part 1 assessed failure within 6 months time to buprenorphine doses >8 mg ≤8 mg. 2 for medications. Sedating cyproheptadine, hydroxyzine, quetiapine, trazodone. Treatment was defined as...
Behavioral disturbances are commonplace among patients with dementia. Management of these symptoms has proved difficult. 1,2 Currently, there no FDA approved pharmacologic treatments for the treatment BPSD.3 Traditionally, atypical antipsychotics have been used to treat behavioral despite modest efficacy and undesirable adverse effects.3 4,5 Because increase in mortality, is a continued push reduce antipsychotic utilization this population. 9,10 Thus, many clinicians using alternative agents...
Depression is the most common psychological condition in patients with cancer. These often have worse outcomes, such as decreased adherence to treatment and increased suicide rates. Since depression under recognized this patient population, guidelines recommend screening every cancer for depression. Both psychotherapy pharmacotherapy are shown be effective treat Psychotherapy, specifically cognitive behavioral therapy, preferred more mild depressive symptoms, while used severe Dignity...
Alzheimer's disease (AD) and other dementias are associated with symptoms that extend far beyond cognitive deficits. The most distressing of these known as the behavioral psychological dementia (BPSD) include delusions, hallucinations, agitation aggression, misidentification, sexually inappropriate behaviors. As a result BPSD, AD patients suffer poorer quality life, do their caregivers.1 Behavioral can be so to caregiver they common reason for families placing loved ones in long-term care....
Introduction: MCL is incurable with standard chemotherapy. Although oral targeted agents are active in MCL, they fail to induce deep responses as monotherapy and require extended duration. We developed a multi-agent regimen (ViPOR) showed it be safe able durable CRs R/R B-cell lymphomas (Melani et al. Blood. 2020). Here, we present data for the cohort of ongoing ViPOR study. Methods: TN pts adequate organ function were eligible. In Ph1, tx at 2 DLs VEN (200 400 mg) identify RP2D. was given...
The use of antipsychotics in the treatment neuropsychiatric symptoms (NPS) geropsychiatric population is a controversial topic. Clinicians must be aware current guidelines and best practices regarding antipsychotic long term care populations due to an associated risk mortality. This article discusses compares NPS published by American College Neuropsychopharmacology World Federation Societies Biological Psychiatry, reviews gradual dose reduction this population.