A5078132192- Oral microbiology and periodontitis research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Immune Response and Inflammation
- Systemic Lupus Erythematosus Research
- Cell Adhesion Molecules Research
- Oral Health Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Streptococcal Infections and Treatments
- Platelet Disorders and Treatments
- Salivary Gland Disorders and Functions
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Dental Radiography and Imaging
- Bone and Dental Protein Studies
- Rheumatoid Arthritis Research and Therapies
- Adipose Tissue and Metabolism
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Bone and Joint Diseases
- Infant Nutrition and Health
- Neonatal and Maternal Infections
- HIV/AIDS oral health manifestations
Niigata University
2012-2024
National Institute of Health Sciences
2021
Meiji Pharmaceutical University
2021
MRC Human Immunology Unit
2006
University of Dundee
2006
University of Oxford
2006
Kyoto Prefectural University
1997
Kitasato University Hospital
1993
Osaka Dental University
1990
Osaka University
1990
Background: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported be periodontitis. This study investigates the effects of periodontal treatment on serum levels leptin other cytokines in patients with chronic (CP). Methods: Serum samples were taken from 33 CP (22 non‐smokers, 11 smokers) 18 healthy subjects. The leptin, adiponectin, tumor necrosis factor‐α, interleukin...
Objectives An interrelationship between rheumatoid arthritis (RA) and periodontitis has been suggested due to their common pathogenic mechanisms. Protein carbamylation neutrophil extracellular traps (NETs) formation have shown be related autoimmune conditions, including RA, but association with not elucidated. Therefore, we assessed whether or circulating levels of carbamylated protein (CarP) NETs are associated severity influenced by periodontal treatment. Methods We conducted a...
Background: The pathobiology of rheumatoid arthritis (RA) is similar to that periodontitis in proinflammatory cytokines and immunoglobulin G Fc receptor (FcγR) play an important role. Functional polymorphisms interleukin (IL)‐1 FcγR were shown be associated with susceptibility both diseases. Therefore, we evaluated whether the IL‐1 gene represent a common risk factor for RA periodontitis. Methods: study population consisted Japanese adults (RA group; N = 100), only (P healthy individuals no...
Genetic polymorphisms of immunoglobulin G (IgG) Fc receptors (FcγR) were recently shown to be associated with recurrence rates adult periodontitis (AP). The purpose this study was evaluate whether FcγR are also generalized early-onset (G-EOP) in Japanese patients.Thirty-eight patients G-EOP and 83 AP identified according established clinical criteria, including measurements probing depth, attachment level, alveolar bone level. genotypes for 3 bi-allelic determined these 104 race-matched...
Functional polymorphisms of immunoglobulin G (IgG) Fc receptors (FcγR) have been shown to be associated with generalized aggressive periodontitis (GAgP) or recurrence chronic (CP) in Japanese patients. The purpose this study was evaluate whether FcγR are also severity CP.Fifty non-smoking patients severe CP and 39 moderate were identified according established clinical criteria, including measurements probing depth (PD), attachment level (CAL), alveolar bone loss (BL). genotypes for 3...
Background: The pathobiology of systemic lupus erythematosus (SLE) is similar to that periodontitis in the immunoglobulin G Fc receptor (FcγR) and proinflammatory cytokines play an important role. Genetic variations FcγR interleukin (IL)‐1 are associated with susceptibility both diseases. Therefore, we evaluated whether combination or IL‐1 polymorphic genes represents a common risk factor for SLE periodontitis. Methods: study population consisted Japanese adults (SLE+P group; n = 46), only...
Early-onset periodontitis (EOP) is considered to have a genetic basis which has not been clearly defined. Genetic polymorphisms of the vitamin D receptor (VDR-B-b) and immunoglobulin-Fcγ IIIb (FcγRIIIb-NA1-NA2) are associated with bone metabolism infectious diseases, respectively. The purpose this study was investigate associations EOP VDR FcγRIIIb polymorphisms. Subjects were comprised those generalized (G-EOP, n = 42), adult (AP, 52), healthy control (HC, 55). genotypes determined by...
Polymorphonuclear neutrophils (PMNs) are essential in host defense against periodontopathic bacteria such as Porphyromonas gingivalis . The uptake of immunoglobulin G (IgG)‐opsonized via IgG Fc receptors (FcγR) on PMN constitutes a central mechanism periodontium. FcγRIIIb is the most abundantly expressed FcγR and functionally polymorphic. FcγRIIIb‐NA1 IIIb‐NA2 allotypes interact differently with IgG1‐ IgG3‐opsonized particles. We recently showed recurrence rates adult periodontitis (AP) to...
The immunoglobulin receptor Fc gamma RIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and delta T polymorphic. RIIIa-158V has a higher affinity for both monomeric immune complexed IgG1, IgG3, IgG4 than IIIa-158F. We determined RIIIa-158V/F genotypes of Japanese patients with adult periodontitis. A significant over-representation RIIIa-158F was found in recurrence, compared without making RIIIA candidate gene recurrence risk
Leukocyte Fc receptors for immunoglobulin G (FcgammaR) play a major role in the handling of immune complexes and pathogens systemic lupus erythematosus (SLE) periodontitis. Both diseases have been shown to be partly influenced by genetic components including FcgammaR genotype. The aim this study was therefore evaluate whether gene polymorphisms are associated with periodontitis risk SLE patients.The subjects consisted 42 patients (SLE/P), 18 without (SLE/H), healthy (H/P), (H/H), who were...
Many elderly people show minimum periodontal tissue destruction, which might be partly due to genetic advantages in host immune response against periodontopathic bacteria. The human IgG Fc receptor IIIb on neutrophils bears a NA1-NA2 polymorphism. FcγRIIIb-NA1 displays more efficient interaction with IgGl- and IgG3-opsonized bacteria, compared the FcγRIIIb-NA2. We investigated 70-year-old Japanese population (n = 599) determine whether FcγRIIIb polymorphism was associated resistance...
Abstract Objective: The purpose of the present study was to investigate effect smoking cessation on peripheral neutrophil mRNA expression levels for inflammatory cytokines, chemokine, growth factor and matrix metalloproteinase (MMP). Material Methods: Sixteen male smokers (aged 22–39 [25.3±4.0] years), with no clinical signs periodontal systemic diseases, were recruited. experiment performed before (baseline) at 1, 4 8 weeks after cessation. status verified by exhaled carbon monoxide (CO)...
Background and Objectives Previous reports suggest that several serum biomarkers play roles in the pathogenesis, inflammatory response, oxidative stress periodontitis caused by bacterial infections, linking chronic to atherosclerotic vascular disease (ASVD). The aim of this preliminary study was investigate, a Japanese cross‐sectional community survey, potential are associated with ASVD periodontitis. Material Methods cohort included total 108 male subjects who underwent annual health...
Abstract Aim To determine whether periodontitis and three prominent members of the periodontal flora are associated with development preeclampsia (hypertension plus proteinuria) Materials Methods The samples were composed 127 systemically healthy women. Within 5 days after labour, clinical parameters Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis Prevotella intermedia in subgingival plaque evaluated. Maternal serum IgG antibody specific for each bacteria was determined by...
Polymorphonuclear leukocytes (PMNLs) are the most numerous cell population among cellular infiltrates in gingival crevicular fluid (GCF) and play important roles host-defensive system crevices. We determined percentage of neutrophils, eosinophils basophils total PMNLs by light microscopic observation using Randolph-methylene blue staining, then assessed flow cytometric differences expression CR3, Fc gamma RIII, epsilon RII, LFA-1 alpha, beta on PMNL GCF peripheral blood (PB) from 21 patients...
Porphyromonas gingivalis has been implicated as a causative pathogen in periodontitis. Immunotherapeutic approaches have recently suggested to aid the clearance of P. from disease sites. Because antibody-Fc receptor (FcR) interactions play role effector functions polymorphonuclear neutrophils (PMN), we evaluated which FcR on PMN gingival crevicular fluid (GCF) serves an optimal target molecule for FcR-directed immunotherapy. GCF and peripheral blood (PB) adult periodontitis patients were...
Porphyromonas gingivalis (Pg) is one of the most harmful periodontal pathogens and it has been reported that Pg associated with preterm birth (PTB), intrauterine growth retardation (IUGR) pregnancy-induced hypertension (PIH), discovered by animal experiments clinical research. The relationship between adverse pregnancy outcomes maternal antibody response to controversial. On other hand, serum C-reactive protein (CRP) recognised as a reliable marker disease.To determine significance responses...
Background: Recent studies suggest an association between maternal periodontitis and preterm birth, although the remains controversial. It was suggested that mechanisms such as a genetic predisposition for hyperinflammatory response cause births. Peroxisome proliferator‐activated receptor gamma (PPARγ) is nuclear hormone ligand‐dependent transcription factor. PPARγ inhibits transcriptional activity of genes produce proinflammatory mediators repress periodontitis. Recently, common...