A5024542973- Advanced biosensing and bioanalysis techniques
- Mosquito-borne diseases and control
- HER2/EGFR in Cancer Research
- Enzyme Structure and Function
- Blood groups and transfusion
- Parasitic infections in humans and animals
- Iron Metabolism and Disorders
- Tea Polyphenols and Effects
- Digital Imaging for Blood Diseases
- Biosensors and Analytical Detection
- Molecular Biology Techniques and Applications
- Quality and Safety in Healthcare
- RNA Interference and Gene Delivery
- Malaria Research and Control
- Glycosylation and Glycoproteins Research
- Curcumin's Biomedical Applications
- Sirtuins and Resveratrol in Medicine
- Respiratory viral infections research
- Parasites and Host Interactions
- Zoonotic diseases and public health
- FOXO transcription factor regulation
- Hormonal and reproductive studies
- SARS-CoV-2 detection and testing
- Reliability and Agreement in Measurement
- Biochemical and Structural Characterization
University of Ghana
2023-2025
Washington University in St. Louis
2016-2017
Missouri State University
2012
To implement a pilot proficiency testing (PT) program in Accra, Ghana, using locally produced PT materials and to explore the relationship between laboratory test costs quality Ghana. Remnant serum samples from local were pooled, aliquoted, distributed convenience sample of 23 laboratories 2 which had International Organization for Standardization (ISO) accreditation. One ISO-accredited was designated as reference/target, range passing based on international criteria. Test cost, results,...
In this review, we examine the current landscape of point-of-care testing (POCT) diagnostic tools designed for poverty-related infectious diseases (PRIDs) in sub-Saharan Africa (sSA) while delineating key avenues future advancements. Our analysis encompasses both established and emerging methods PRIDs, addressing persistent challenges POCT tool development deployment, such as cost, accessibility, reliability. We emphasize recent advancements well platforms poised to enhance sSA. Recognizing...
The epidermal growth factor receptor (EGFR)/ErbB family of tyrosine kinases includes oncogenes important in the progression breast and other cancers, they are targets for many drug development strategies. Each member ErbB possesses a unique, structurally uncharacterized C-terminal tail that plays an role autophosphorylation signal propagation. To determine whether these tails intrinsically disordered regions, we conducted battery biophysical experiments on EGFR HER3 tails. Using...
The binding affinity and specificity of nucleic acid aptamers have made them valuable candidates for use as sensors in diagnostic applications. In particular, chromophore-functionalized offer a relatively simple format detection quantification target molecules. We describe the nucleic-acid-staining reagents an effective tool detecting signaling aptamer-target interactions. Aptamers varying size structure targeting range molecules been used conjunction with commercially available chromophores...
An inverse comorbidity has been observed between Down syndrome (DS) and solid tumors such as breast lung cancers, it is posited that the overexpression of genes within Syndrome Critical Region (DSCR) human chromosome 21 may account for this phenomenon. By analyzing publicly available DS mouse model transcriptomics data, we aimed to identify DSCR protect against cancers. Gene expression analyses with GEPIA2 UALCAN showed ETS2 RCAN1 are significantly downregulated in their levels higher...
Haemoglobinopathies, including sickle cell disease and β-thalassaemia, are monogenic disorders with a relatively higher prevalence among malaria-endemic areas in Africa. Despite this prevalence, most African countries lack the necessary resources for diagnosing managing these debilitating conditions.This study provides critical review of newborn screening detecting haemoglobinopathies Africa, highlighting challenges proposing strategies improved diagnosis management.A literature search on...
Background: Triple-negative breast cancer (TNBC) remains a significant clinical challenge due to its aggressive nature and lack of targeted therapies. In TNBC, inflammation contributes tumour progression by promoting cell proliferation, survival, migration. It may be triggered cytokines such as TNF-α or chemotherapeutic agents doxorubicin (DOX). Thus, identifying that suppress in TNBC is prime interest. Caffeic acid phenethyl ester (CAPE) naturally occurring anti-inflammatory compound...
Abstract Background Malaria presents a public health menace to millions of people in LMICs, killingmore than 600 000 with the highest number children living sub-Saharan Africa.Laboratory testing provides basis for >70% clinical decisions, although their accessibilityand affordability are limited LMICs and results syndromic diagnosis self-medication.The National Control Program guidelines specify that healthcare facilities perform RapidDiagnostic Testing (RDT) or microscopy malaria....