A5103061845- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Systemic Lupus Erythematosus Research
- Blood properties and coagulation
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Ocular Surface and Contact Lens
- Helicobacter pylori-related gastroenterology studies
- Diatoms and Algae Research
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Drug-Induced Hepatotoxicity and Protection
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- Chemokine receptors and signaling
University of Palermo
1996-2024
Bombay Hospital
2009
Ospedale Vincenzo Cervello
1992
University of Pavia
1981-1986
Istituto di Sessuologia Clinica
1981
The effect of lamivudine treatment on the outcome patients with hepatitis B e antigen (HBeAg)-negative chronic is unclear. In a retrospective multicenter study, we have analyzed virological events observed during therapy in HBeAg-negative and evaluated correlation between response clinical outcomes. Among 656 (mean age 49.1 years) included database, 54% had hepatitis, 30% Child-Turcotte-Pugh (CTP) A cirrhosis, 16% CTP B/C cirrhosis. On (median 22 months, range 1-66), was obtained 616...
AIM:To estimate the prevalence of small intestinal bacterial overgrowth (SIBO) in our geographical area (Western Sicily, Italy) by means an observational study, and to gather information on use locally active, nonabsorbable antibiotics for treatment SIBO. METHODS:Our survey included 115 patients fulfilling Rome Ⅱ criteria diagnosis irritable bowel syndrome (IBS); a total 97 accepted perform breath test with lactulose (BTLact), those who had positive test, received Rifaximin (Normix ® , Alfa...
The aim of the study was to evaluate characteristics chronic hepatitis B with special reference geographical origin patients and prevalence HBeAg viral non-viral co-factors liver disease. A cross-sectional multicenter survey undertaken, which enrolled 1,386 HBsAg carriers observed consecutively in 21 referral centers over a 6-month period. 11%; presence associated independently younger age co-infection HIV. Anti-HDV, anti-HCV, or anti-HIV antibodies were detected 8.1%, 6.5%, 2%,...
AIM:To evaluate the clinical relevance of each cofactor on presentation chronic hepatitis B. METHODS:Out 1366 B surface antigen (HBsAg) positive subjects consecutively observed in 79 Italian hospitals, 53 (4.3%) showed as only D virus (HDV) infection [hepatitis (HBV)/HDV group], 130 (9.5%) C (HCV) (group HBV/HCV), 6 (0.4%) human immunodeficiency (HIV) HBV/HIV), 138 (10.2%) alcohol abuse HBV/alcohol); 109 (8.0%) had at least two cofactors and 924 were cofactor-free (CF) group....
Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of disease cohort 191 transfusion-dependent thalassemics, 126 patients who had undergone biopsy (mean age 17.2 years; 58 C-RNA positive 68 negative) the iron concentration (median 2.4 mg/gr dry weight) was closely related to serum ferritin levels (R = 0.58; p<0.0001). Male gender (OR 4.12) positivity 11.04) were independent risk factors for advanced fibrosis. The...
In hepatitis B virus (HBV) cirrhosis patients on long-term lamivudine (LAM), the relationships between HBV suppression, development of viral resistance and disease outcome are unclear. We analysed dynamic serum HBV-DNA its relationship with clinical course 59 (52 males, mean age 51.4 +/- 8.4 years, 12 HBeAg positive 47 negative, 57 genotype D two A) (45 in Child-Turcotte-Pugh class high levels (median 14.7 x 10(7) genomes/ml) treated LAM [median (range): 44 (15-78) months]. A total 50...
We studied the mechanisms of platelet activation by sublines exhibiting different metastatic potential two murine experimental tumors: M4 and M9 benzopyrene-induced mFS6 sarcoma B77-AA6 B77-3T3 RSV-transformed BALB/c 3T3 fibroblasts. The neoplastic cells both models induced aggregation, secretion prostaglandin biosynthesis. In first model but not in second, all these processes correlated with vivo malignancy cells. Pretreatment apyrase significantly decreased while pretreatment was...
While the likelihood of developing hepatocellular carcinoma (HCC) in patients coinfected with both HBV and HCV is increased, role previous exposure to as a risk factor associated tumor occurrence subjects HCV-related cirrhosis has not been fully investigated.To assess whether serum anti-HBc positivity, marker exposure, HCC development positive, hepatitis B surface antigen (HBsAg) negative treated alfa-interferon (IFN) monotherapy. PATIENTS AND: A database including 883 consecutive (557 men,...
The increase in the incidence of thyroid nodules with cytological findings TIR3b requires identification predictive factors malignancy. We prospectively evaluated 2160 patients from January 2018 to June 2022 and enrolled 103 indeterminate cytology who underwent total (73 patients) hemi-thyroidectomy (30 patients). Among them, 61 had a histological diagnosis malignancy classic papillary carcinoma, 19 follicular carcinoma variant, 3 Hurtle cell 9 carcinoma), while 42 benign histology....
Background The joint effect of the interaction alcohol intake, hepatitis B virus (HBV) and C (HCV) on risk cirrhosis is still unexplored because a large sample size required for this investigation. Objective Evaluation HBV, HCV abuse cirrhosis. Design We analysed 12,262 consecutive patients with chronic liver disease various aetiologies referring to 95 Italian units in 2001 or 2014. To evaluate between abuse, HBV infection, unexposed either factors were used as reference category. Adjustment...
The plasma levels of the opsonic glycoprotein fibronectin are decreased in patients with fulminant hepatic failure, which may be an important factor their impaired host-defense. Twenty-nine failure were studied on admission, and mean level Grade 0-2 encephalopathy was 82 μg per ml (range = 0 to 150) 3-4 61 5 158) as compared normal controls (268 ml, range 178 380, n 62). No degradation products could detected by sodium dodecyl sulfate-gel electrophoresis a polyacrylamide gradient (5 15%)...
Fattovich, Giovanna; Giustina, Giuliano; Sanchez-Tapias, José; Quero, Carlos; Mas, Anna; Olivotto, Pia Grazia; Solinas, Antonio; Almasio, Piero; Hadziyannis, Stephanos; Degos, Francoise; dr Moura, Miguel Carneiro; Krogsgaard, Kim; Pantalena, Maurizio; Realdi, Giuseppe; Corrocher, Roberto; Schalm, Solko W.