A5018141340- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- CO2 Reduction Techniques and Catalysts
- Electrocatalysts for Energy Conversion
- Probiotics and Fermented Foods
- Electrochemical Analysis and Applications
- Multiferroics and related materials
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Metal complexes synthesis and properties
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Plant Genetic and Mutation Studies
- Protein Hydrolysis and Bioactive Peptides
- Magnetic Properties and Applications
- Vanadium and Halogenation Chemistry
- Biochemical and Structural Characterization
- Oxidative Organic Chemistry Reactions
- Metalloenzymes and iron-sulfur proteins
- Food Quality and Safety Studies
- Microbial Metabolic Engineering and Bioproduction
Rice University
2024
Cornell University
2017-2023
Jiangnan University
2013
Yebio Bioengineering (China)
2012
Hydrogen-atom transfer mediated by earth-abundant transition-metal hydrides (M-Hs) has emerged as a powerful tool in organic synthesis. Current methods to generate M-Hs most frequently rely on oxidatively initiated hydride transfer. Herein, we report reductive approach Co-H, which allows for canonical hydrogen evolution reactions be intercepted hydrogen-atom an alkene. Electroanalytical and spectroscopic studies provided mechanistic insights into the formation reactivity of enabled...
We report a stereoselective formal [3 + 2] cycloaddition of cyclopropyl ketones and radical-acceptor alkenes to form polysubstituted cyclopentane derivatives. Catalyzed by chiral Ti(salen) complex, the occurs via radical redox-relay mechanism constructs two C–C bonds contiguous stereogenic centers with generally excellent diastereo- enantioselectivity.
We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis pyrrolidines, structural units prevalent in bioactive compounds organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses intermediates for selective C—N bond cleavage formation.
Alkyl chlorides are common functional groups in synthetic organic chemistry. However, the engagement of unactivated alkyl chlorides, especially tertiary transition-metal-catalyzed C–C bond formation remains challenging. Herein, we describe development a TiIII-catalyzed radical addition 2° and 3° to electron-deficient alkenes. Mechanistic data consistent with inner-sphere activation C–Cl featuring TiIII-mediated Cl atom abstraction. Evidence suggests that active TiIII catalyst is generated...
New catalytic strategies that leverage single-electron redox events have provided chemists with useful tools for solving synthetic problems. In this context, Ti offers opportunities are complementary to late transition metals reaction discovery. Following foundational work on epoxide reductive functionalization, recent methodological advances significantly expanded the repertoire of radical chemistry. This Synopsis summarizes developments in burgeoning area catalysis a focus innovative such...
Radical chemistry has emerged as a cornerstone in modern organic synthesis, providing chemists with numerous new tools to rapidly expand reactivity and chemical space academic industrial research. In this regard, titanium complexes have been recognized an attractive class of catalysts owing their rich redox activities addition the abundance low toxicity early transition metal. Traditionally employed for activation epoxides carbonyl compounds, Ti radical catalysis broken into grounds recent...
Ti(salen) complexes catalyze the asymmetric [3 + 2] cycloaddition of cyclopropyl ketones with alkenes. While high enantioselectivities are achieved electron-rich alkenes, electron-deficient alkenes less selective. Herein, we describe mechanistic studies to understand origins catalyst and substrate trends in an effort identify a more general catalyst. Density functional theory (DFT) calculations selectivity determining transition state revealed origin stereochemical control be distortion,...
A flurry of recent research has centered on harnessing the power nickel catalysis in organic synthesis. These efforts have been bolstered by contemporaneous development well-defined (pre)catalysts with diverse structure and reactivity. In this report, we present ten different bench-stable, 18-electron, formally zero-valent nickel-olefin complexes that are competent pre-catalysts various reactions. Our investigation includes preparations novel, bench-stable Ni(COD)(L)...
The utility of transition metal hydride catalyzed hydrogen atom transfer (MHAT) has been widely demonstrated in organic transformations such as alkene isomerization and hydrofunctionalization reactions. However, the highly reactive nature radical intermediates hindered mechanistic insight into this pivotal reaction. Recent advances electrochemical MHAT have opened up possibility for new analytical approaches diagnosis. Here, we report a voltammetric interrogation Co-based reactivity,...
Abstract Over the last fifty years, use of nickel catalysts for facilitating organic transformations has skyrocketed. Nickel(0) sources act as useful precatalysts because they can enter a catalytic cycle through ligand exchange, without needing to undergo additional elementary steps. However, most Ni(0) are synthesized with stoichiometric aluminum–hydride reductants, pyrophoric reagents that not atom‐economical and must be used at cryogenic temperatures. Here, we demonstrate Ni(II) salts...
The utility of transition metal hydride catalyzed hydrogen atom transfer (MHAT) has been widely demonstrated in organic transformations such as alkene isomerization and hydrofunctionalization reactions. However, the highly reactive nature radical intermediates hindered mechanistic insight into this pivotal reaction. Recent advances electrochemical MHAT have opened possibility for new analytical approaches diagnosis. Here, we report a voltammetric interrogation Co-based reactivity, describing...
A flurry of recent research has centered on harnessing the power nickel catalysis in organic synthesis. These efforts have been bolstered by contemporaneous synthesis, characterization, and optimization well-defined (pre)catalysts with diverse structure reactivity. In this report, we present development ten different bench-stable, 18-electron, formally zero-valent nickel–olefin complexes that are shown to be competent pre-catalysts various reactions. Our investigation includes preparations...
Hydrogen-atom transfer mediated by earth-abundant transition-metal hydrides (M-Hs) has emerged as a powerful tool in organic synthesis. Current methods to generate M-Hs most frequently rely on oxidatively initiated hydride transfer. Herein, we report reductive approach Co-H, which allows for canonical hydrogen evolution reactions be intercepted hydrogen-atom an alkene. Electroanalytical and spectroscopic studies provided mechanistic insights into the formation reactivity of enabled...
This report introduces a solution to The task of RGB-TIR object detection from the perspective unmanned aerial vehicles. Unlike traditional methods, aims utilize both RGB and TIR images for complementary information during detection. challenges vehicles include highly complex image backgrounds, frequent changes in lighting, uncalibrated pairs. To address these at model level, we utilized lightweight YOLOv9 with extended multi-level auxiliary branches that enhance model's robustness, making...
Over the last fifty years, use of nickel catalysts for facilitating organic transformations has skyrocketed. Ni(0) sources act as useful precatalysts because they can enter a catalytic cycle through ligand exchange, without needing to undergo additional elementary steps. However, most are synthesized with stoichiometric aluminum–hydride reductants, pyrophoric reagents that not atom-economical and must be used at cryogenic temperatures. Here, we demonstrate Ni(II) salts reduced on preparative...
Abstract A flurry of recent research has centered on harnessing the power nickel catalysis in organic synthesis. These efforts have been bolstered by contemporaneous development well‐defined (pre)catalysts with diverse structure and reactivity. In this report, we present ten different bench‐stable, 18‐electron, formally zero‐valent nickel–olefin complexes that are competent pre‐catalysts various reactions. Our investigation includes preparations novel, bench‐stable Ni(COD)(L)...
Abstract Over the last fifty years, use of nickel catalysts for facilitating organic transformations has skyrocketed. Nickel(0) sources act as useful precatalysts because they can enter a catalytic cycle through ligand exchange, without needing to undergo additional elementary steps. However, most Ni(0) are synthesized with stoichiometric aluminum–hydride reductants, pyrophoric reagents that not atom‐economical and must be used at cryogenic temperatures. Here, we demonstrate Ni(II) salts...
This study introduces a method for the characterization of magnetoelectric coupling in nanoscale Pb(Zr,Ti)O3/CoFeB thin film composites based on propagating spin-wave spectroscopy. Finite element simulations strain distribution devices indicated that magnetoelastic effective field CoFeB waveguides was maximized Damon - Eshbach configuration. All-electrical broadband transmission measurements were conducted with lateral dimensions down to 700 nm. The results demonstrated resonance frequency...