A5073155817- Spine and Intervertebral Disc Pathology
- Heterotopic Ossification and Related Conditions
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Management of metastatic bone disease
- Osteoarthritis Treatment and Mechanisms
- Genetic Syndromes and Imprinting
- Proteoglycans and glycosaminoglycans research
- Cervical and Thoracic Myelopathy
- Periodontal Regeneration and Treatments
- Myofascial pain diagnosis and treatment
- Bone fractures and treatments
- Veterinary Equine Medical Research
- Parathyroid Disorders and Treatments
- Veterinary Orthopedics and Neurology
Imperial College London
2020-2024
Ollscoil na Gaillimhe – University of Galway
2015-2020
AO Foundation
2015-2016
Abstract Low back pain is a major cause of disability especially for people between 20 and 50 years age. As costly healthcare problem, it imposes serious socio-economic burden. Current surgical therapies fail to replace the normal disc in facilitating spinal movements absorbing load. The focus regenerative medicine on identifying biomarkers signalling pathways improve our understanding about cascades degeneration allow design specific therapies. We hypothesized that comparing microarray...
Abstract Low back pain results from disc degeneration, which is a chronic inflammatory disease characterized by an imbalance between anabolic and catabolic factors. Today, regenerative medicine focused on identifying markers to target disease. Hyaluronan used as scaffold for cell delivery in degeneration; however, date high molecular weight hyaluronan (HMW HA) evaluated its anti‐inflammatory matrix modulatory properties vivo injury model. Ex bovine organ culture studies demonstrate the...
Intervertebral disc (IVD) degeneration is a leading cause of low back pain worldwide, incurring significant burden on the healthcare system and society. IVD characterized by an abnormal cell-mediated response to stimulation different catabolic biomarkers activation signalling pathways. In last few decades, hyaluronic acid (HA), which has been broadly used in tissue-engineering, popularised due its anti-inflammatory, analgesic extracellular matrix enhancing properties. Hence, there expressed...
Aims In recent conflicts, most injuries to the limbs are due blasts resulting in a large number of lower limb amputations. These lead heterotopic ossification (HO), phantom pain (PLP), and functional deficit. The mechanism blast loading produces combined fracture amputation. Therefore, study these conditions, vivo models that replicate this effect required. aim is develop preclinical model blast-induced Methods Cadaveric Sprague-Dawley rats’ left hindlimbs were exposed waves 7 13 bar burst...