A5033437013- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Inorganic Fluorides and Related Compounds
- Sulfur-Based Synthesis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Machine Learning in Materials Science
- CO2 Reduction Techniques and Catalysts
- Ionic liquids properties and applications
- Advanced battery technologies research
- Carbon dioxide utilization in catalysis
- Advancements in Battery Materials
- Phenothiazines and Benzothiazines Synthesis and Activities
- Quinazolinone synthesis and applications
- Electrochemical Analysis and Applications
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Analysis
- Green IT and Sustainability
Johns Hopkins University
2025
Guangzhou Experimental Station
2022
South China University of Technology
2016-2019
A stereoselective synthesis of (E)-vinyl sulfones has been developed via electrochemical oxidative N–S bond cleavage aromatic sulfonylhydrazides, followed by cross-coupling reactions with cinnamic acids to form the C–S bond. The protocol proceeded smoothly afford in good yields wide substrate scope under metal-free and halogen-free conditions.
Thiocyanate compounds are key intermediates in the synthesis of pharmaceuticals and other sulfur-containing organic compounds. Herein, we first report an electrochemical protocol to synthesize vinyl thiocyanates from decarboxylative coupling cinnamic acids with NH4SCN aqueous solution. This method provides thiocyanation products broad functional group tolerance under ambient conditions.
A new method for the synthesis of formamides has been developed through electrochemical decarboxylative N-formylation amines with glyoxylic acid. This protocol provides an efficient approach to a broad range functional group tolerance under ambient conditions.
A new method for 3-formalytion of indoles has been developed through electrochemical decarboxylation glyoxylic acid with the amine as a dual function organocatalyst. The facilitated both and nucleophilic reaction efficiently, whose loading can be low 1 mol %. This protocol broad range functional group tolerance under ambient conditions. gram-scale experiment shown great potential in synthetic application this strategy.
Copper-catalyzed decarboxylative difluoroalkylation and perfluoroalkylation of α,β-unsaturated carboxylic acids is described. Promoted by dialkyl phosphite, this novel reaction affords fluoroalkylated motifs with excellent stereoselectivity broad substrate scope under mild conditions from readily available fluoroalkyl iodides bromides. Preliminary mechanism study suggests that radical pathway was involved in the catalytic cycle phosphite had played an indispensable role reaction.
Abstract An efficient approach for the synthesis of quinazolinones from o ‐aminobenzamides and alcohols by combination electrochemistry redox‐metal catalysis has been developed. Taking manganese(II) sulfate as a redox catalyst, this transformation proceeded smoothly under ambient conditions in an undivided cell to afford moderate excellent yields with wide substrate scope. Benzyl ethers were also suitable participants cascade cyclization sequence.
Automating electrochemical analyses combined with artificial intelligence is poised to accelerate discoveries in renewable energy sciences and technologies. This study presents an automated high-throughput characterization (AHTech) platform as a cost-effective versatile tool for rapidly assessing liquid analytes. The Python-controlled combines handling robot, potentiostat, customizable microelectrode bundles diverse, reproducible measurements microtiter plates, minimizing chemical...
Abstract A new method for the synthesis of vinyl trifluoromethyl compounds from α, β ‐unsaturated carboxylic acids and CF 3 SO 2 Na has been developed. This electrochemical decarboxylative trifluoro‐methylation was found to be highly stereoselective afforded products in good yields with wide substrate scope under metal‐free external chemical oxidant‐free conditions.
Abstract Traditional synthesis made outstanding achievements but still suffers various drawbacks, such as manual operation, poor efficiency, and lack of reproducibility. Thanks to the development laboratory automation, synthetic chemistry is now chasing a pavement from labor‐intensive process intelligent automation. Herein, we highlight some most recent representative breakthroughs in automated present an outlook for this field. We hope Topic can arouse chemists’ interest drive automation...