A5056610320- S100 Proteins and Annexins
- Inflammatory mediators and NSAID effects
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Eicosanoids and Hypertension Pharmacology
- Lanthanide and Transition Metal Complexes
- Synthesis and Biological Evaluation
- Finance, Markets, and Regulation
- Bone Metabolism and Diseases
- Social Issues in Poland
- Neuropeptides and Animal Physiology
- Metal complexes synthesis and properties
- Polish Legal and Social Issues
- ATP Synthase and ATPases Research
- Microtubule and mitosis dynamics
- Nanocluster Synthesis and Applications
Stevenage Bioscience Catalyst
2021-2022
Antikor (United Kingdom)
2021-2022
LifeArc
2018-2021
Queen Mary University of London
2021
William Harvey Research Institute
2021
Jagiellonian University
2014
Institut de Chimie Organique et Analytique
2014
Université d'Orléans
2014
Centre National de la Recherche Scientifique
2014
Abstract Energy and biomass production in cancer cells are largely supported by aerobic glycolysis what is called the Warburg effect. The process regulated key enzymes, among which phosphofructokinase PFK‐2 plays a significant role producing fructose‐2,6‐biphosphate; most potent activator of rate‐limiting step performed PFK‐1. Herein, synthesis, biological evaluation structure–activity relationship novel inhibitors 6‐phosphofructo‐2‐kinase/fructose‐2,6‐biphosphatase 3 (PFKFB3), ubiquitous...
The discovery of natural specialized pro-resolving mediators and their corresponding receptors, such as formyl peptide receptor 2 (FPR2), indicated that resolution inflammation (RoI) is an active process which could be harnessed for innovative approaches to tame pathologies with underlying chronic inflammation. In this work, homology modelling, molecular docking pharmacophore studies were deployed assist the rationalization structure-activity relationships known FPR2 agonists. developed...
A series of Formyl peptide receptor 2 small molecule agonists with a pyrrolidinone scaffold, derived from combination pharmacophore modelling and docking studies, were designed synthesized. The GLASS (GPCR-Ligand Association) database was screened using model. most promising novel ligand structures chosen then tested in cellular assays (calcium mobilization β-arrestin assays). Amongst the selected ligands, two compounds (7 8) turned out to be active. Moreover compound 7 able reduce number...
Abstract Despite the recent resurgence, Antibody Drug Conjugates (ADCs) are failing to address challenging cancer indications due 3 critical limitations: Low potency, ineffective solid-tumour penetration and poor tolerability. The industry is well-served by approaches where full-length Immunoglobulins designed carry defined numbers of payloads. However, antibody fragments (e.g. single-chain Fvs-scFvs), which have many advantages including rapid tumour penetration, faster clearance,...
Abstract Antibody Drug Conjugates (ADCs) are failing due to 3 critical limitations: Low potency, ineffective solid-tumor penetration and poor tolerability. The industry is full of approaches where full-length Immunoglobulins have been engineered carry defined numbers payloads with higher-loadings less potent appearing be well-tolerated. However, antibody fragments (e.g. single-chain Fcs-scFvs), which many advantages including rapid tumor penetration, faster clearance, inexpensive...