A5005387772- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Biofuel production and bioconversion
- Protein purification and stability
- Amino Acid Enzymes and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Chemistry and Chemical Engineering
- Crystallization and Solubility Studies
- Steroid Chemistry and Biochemistry
- Analytical Chemistry and Chromatography
- Catalysis for Biomass Conversion
- Chemical Synthesis and Analysis
- Carbon dioxide utilization in catalysis
- Pancreatic function and diabetes
- Innovative Microfluidic and Catalytic Techniques Innovation
RWTH Aachen University
2018-2021
Centro Universitário Newton Paiva
2020
Boehringer Ingelheim (Austria)
2020
Forschungszentrum Jülich
2016-2018
Atom economy and E-factor calculations are valuable tools in the sustainable process design of fine pharmaceutical chemicals. Adjoined with smart assembly biocatalysts artificial cascades, chemicals can be produced high efficiency selectivity, while also reducing ecological footprint. In this study, all four isomers 4-methoxyphenyl-1,2-propanediol, a potential anti-inflammatory drug, synthesized by stereocomplementary carboligases NADPH-dependent alcohol dehydrogenases one-pot, two-step...
The economically efficient utilization of NADPH or NADH-dependent enzymes requires the regeneration consumed reduction equivalents. This cofactor is classically done via an additional substrate, and if necessary enzyme. We now demonstrate easy-to-apply approach, which can especially be used in screening applications. Simply by applying citrate to a buffer directly using citrate/-phosphate regenerated native TCA cycle, practically present all aerobic living organisms. Apart from...
Abstract Miniaturization and automation have become increasingly popular in bioprocess development recent years, enabling rapid high‐throughput screening optimization of process conditions. In addition, advances the bioprocessing industry led to complex designs, such as pH temperature shifts, microbial fed‐batch fermentations for optimal soluble protein expression a range hosts. However, order develop an accurate scale‐down model optimization, small‐scale bioreactors must be able accurately...
How can high product concentrations be continuously provided, while dealing with substrate toxicity? Which method leads to a straight forward isolation? The example of model based process intensification shows how.