A5101719858- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Advanced oxidation water treatment
- Advanced biosensing and bioanalysis techniques
- Iron oxide chemistry and applications
- RNA Interference and Gene Delivery
- Advanced Photocatalysis Techniques
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Environmental remediation with nanomaterials
- Wound Healing and Treatments
- Photoacoustic and Ultrasonic Imaging
- Bacteriophages and microbial interactions
- Graphene and Nanomaterials Applications
- MXene and MAX Phase Materials
- Chemotherapy-induced cardiotoxicity and mitigation
- Light effects on plants
- Graphene research and applications
- Photosynthetic Processes and Mechanisms
- Virus-based gene therapy research
- Polymer Surface Interaction Studies
- Ultrasound and Hyperthermia Applications
- Metal Extraction and Bioleaching
- Immune cells in cancer
Renji Hospital
2022-2025
Shanghai Jiao Tong University
2022-2025
Shanghai Cancer Institute
2022-2025
Dalian Jiaotong University
2024-2025
Ruijin Hospital
2023-2024
State Key Laboratory of Oncogene and Related Genes
2022-2023
First Affiliated Hospital of Zhengzhou University
2020-2023
Jilin Province Tumor Hospital
2021
Fudan University
2020
Institute of Botany
2015
An approach of decorating bacteria with triple immune nanoactivators is reported to develop tumor-resident living immunotherapeutics. Under cytocompatible conditions, tumor-specific antigens and checkpoint blocking antibodies are simultaneously conjugated onto bacterial surface then polydopamine nanoparticles formed via in situ dopamine polymerization. In addition serving as a linker, its photothermal effect can repolarize tumor-associated macrophages pro-inflammatory phenotype. The linked...
Photosensitizer-based therapy often suffers from unitary and easily attenuated photosensitive effects, limited tumor penetration retention, requirement of multiple irradiation for combination therapy, which largely restrict its application. Here, bacteria are integrated with a monochromatic irradiation-mediated ternary photosensitizers photoacoustic imaging-guided synergistic photothermal therapy. Bacteria that bioengineered to express natural melanin decorated dual synthetic by...
Abstract Two‐dimensional (2D) monoelemental materials (Xenes) show considerable potential in bioapplications owing to their unique 2D physicochemical features and the favored biosafety resulting from composition. However, narrow band gaps of Xenes prevent broad applications biosensors, bioimaging phototherapeutics. In this study, it is demonstrated that germanene terminated with −H via surface chemical engineering, shows a much broadened direct gap 1.65 eV, which enables material be used as...
Abstract Distressing and lethal cardiotoxicity is one of the major severe side effects using anthracycline drugs such as doxorubicin for cancer chemotherapy. The currently available strategy to counteract these relies on administration cardioprotective agents Dexrazoxane, which unfortunately has unsatisfactory efficacy produces secondary myelosuppression. In present work, aiming target characteristic ferrous iron overload in doxorubicin-contaminated cardiac microenvironment, a biocompatible...
Abstract Bacteria‐based vaccines have received increasing attention given the ability to induce strong systemic immune responses. However, application of bacteria as therapeutic agents inevitably suffers from infection‐associated side effects due living characteristics. Here, use bacteria‐derived flagella is described construct self‐adjuvated nanofiber vaccines. With help charge‐reversal mediated by decoration with cationic polymers, can be coated negatively charged antigens through...
Abstract Two‐dimensional (2D) monoelemental materials (Xenes) show considerable potential in bioapplications owing to their unique 2D physicochemical features and the favored biosafety resulting from composition. However, narrow band gaps of Xenes prevent broad applications biosensors, bioimaging phototherapeutics. In this study, it is demonstrated that germanene terminated with −H via surface chemical engineering, shows a much broadened direct gap 1.65 eV, which enables material be used as...
Drug resistance presents serious difficulties for cancer treatment. A combination of paclitaxel (PTX) and lapatinib (LAPA) shows potentials in multiple drug resistant cancers the clinic, but it is almost impossible to deliver these two drugs tumor at same time with best proportion by simple co-administration respective current formualtions their different pharmacokinetic profiles. Here composite nanocrystals PTX LAPA (cNC) were designed a ratio 2:1 (w/w), which was intracellular synergistic...
The high-performance photonic drug-delivery nanoplatform on the basis of ultrathin silicene nanosheets was constructed for achieving synergistic chemotherapeutic and phototherapeutic efficiency against tumor.
Wound infections, especially those caused by pathogenic bacteria, present a considerable public health concern due to associated complications and poor therapeutic outcomes. Herein, we developed antibacterial nanoparticles, namely, PGTP, coordinating guanidine derivatives with porphyrin-based sonosensitizer. The synthesized PGTP characterized their strong positive charge, effectively disrupted the bacterial biosynthesis process through charge interference, demonstrating efficacy against both...
Skin-nerve interaction plays an important role in promoting wound healing. However, diabetic ulcers (DUs), the periphery neuropathy and excessive levels of reactive oxygen species (ROS) block skin-nerve further impede DUs Herein, we developed a nanoscale metal-organic framework loaded with nerve growth factor (NGF/Ce-UiO-66, denoted NGF/CU) for treatment DUs. The Ce-UiO-66 (CU) was applied as antioxidant to scavenge ROS reduce inflammatory response while NGF aided recovery cutaneous nerves...
Abstract Low transfection efficacy of non‐viral gene vectors restricts their applications. In this paper, N 1 ,N 3 ‐dicarbamimidoyl‐5‐methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions an aryl ring. BGG conjugated with PAMAM G5 (G5‐BGG) and G5‐BGG/DNA complex dispersed into polyvinyl alcohol (PVA) hydrogel for local injection. Molecular docking, NMR, IR Isothermal titration calorimetry (ITC) experiments demonstrate that...
Abstract An approach of decorating bacteria with triple immune nanoactivators is reported to develop tumor‐resident living immunotherapeutics. Under cytocompatible conditions, tumor‐specific antigens and checkpoint blocking antibodies are simultaneously conjugated onto bacterial surface then polydopamine nanoparticles formed via in situ dopamine polymerization. In addition serving as a linker, its photothermal effect can repolarize tumor‐associated macrophages pro‐inflammatory phenotype. The...
Abstract The combination of immunotherapy and chemotherapy to ablate tumors has attracted substantial attention due the ability simultaneously elicit antitumor immune responses trigger direct tumor cell death. However, conventional combinational strategies mainly focus on employment drug carriers deliver immunomodulators, chemotherapeutics, or their combinations, always suffering from complicated preparation carrier‐relevant side effects. Here, fabrication bacterial flagellum‐drug...
Motivation: It is in urgent need to develop an imaging method reveal the intrinsic ‘cold’ or ‘hot’ status of tumor microenvironment for glioma patients, which would offer guidance planning therapeutic regimen, and thus maximize efficacy reduce unnecessary treatment. Goal(s): To visualize inflammatory non-invasively using myeloperoxidase responsive NaGdF4-based nanoprobes under MRI. Approach: Different models with different were created imaged our 11.7...
Oral squamous cell carcinoma (OSCC) can metastasize from the primary tumor area to regional lymph nodes at an early stage. Considering that current imaging detection is not reliable, a better treatment for urgently needed. From perspective of photothermal therapy (PTT), poly(lactic-co-glycolic acid) (PLGA) was used as carrier, and reverse drug-resistant RNA-adriamycin (ADR) indocya-nine green (IND) were encapsulated in carrier. The chemokine SDF-a introduced coupled with drug carrier by...