A5041199482- Tuberculosis Research and Epidemiology
- Effects and risks of endocrine disrupting chemicals
- Mycobacterium research and diagnosis
- Bacterial Genetics and Biotechnology
- Toxic Organic Pollutants Impact
- Escherichia coli research studies
- Quantum and Classical Electrodynamics
- Carcinogens and Genotoxicity Assessment
- Vibrio bacteria research studies
- Reproductive System and Pregnancy
- Synthesis and Biological Evaluation
- Biochemical and Molecular Research
- Shoulder and Clavicle Injuries
- Reproductive Physiology in Livestock
- Antibiotic Resistance in Bacteria
- Plant and fungal interactions
- Black Holes and Theoretical Physics
- Shoulder Injury and Treatment
- Pesticide Exposure and Toxicity
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Reproductive Biology and Fertility
- Sulfur-Based Synthesis Techniques
- Estrogen and related hormone effects
- Cancer therapeutics and mechanisms
Missouri College
2013-2022
University of Missouri
1998-2022
Moffitt Cancer Center
2022
California State University, Fresno
2018-2021
Henry Ford Hospital
2017-2020
Geoscience Australia
2010-2020
University of Kentucky
2013-2018
Henry Ford Health System
2018
AstraZeneca (United Kingdom)
2015
American Sports Medicine Institute
2014-2015
Shoulder injuries from repetitive baseball pitching continue to be a serious, common problem.To determine whether passive range of motion the glenohumeral joint was predictive shoulder injury or surgery in professional pitchers.Cohort study; Level evidence, 2.Passive assessed with bubble goniometer during spring training for all major and minor league pitchers single organization over period 8 successive seasons (2005-2012). Investigators performed total 505 examinations on 296 pitchers....
Background: Injuries to the elbow joint in baseball pitchers appear common. There appears be a correlation between shoulder range of motion and injuries. Purpose: To prospectively determine whether decreased ROM throwing is correlated with onset injuries professional pitchers. Study Design: Cohort study; Level evidence, 2. Methods: For 8 consecutive years (2005-2012), passive both nonthrowing shoulders all major minor league within single organization were measured by using bubble goniometer...
This paper describes the identification and optimization of a novel series DFG-out binding p38 inhibitors as inhaled agents for treatment chronic obstructive pulmonary disease. Structure based drug design "inhalation by design" principles have been applied to lead exemplied compound 1a. Analogues designed be potent selective p38, with an emphasis on slow enzyme dissociation kinetics deliver prolonged lung inhibition. Pharmacokinetic properties were tuned high intrinsic clearance low oral...
The growth or virulence of Mycobacterium tuberculosis bacilli depends on homologous type VII secretion systems, ESX-1, ESX-3 and ESX-5, which export a number protein effectors across membranes to the bacterial surface environment. PE PPE proteins represent two large families highly polymorphic that are secreted by these ESX systems. Recently, it was shown require system-specific cytoplasmic chaperones for secretion. Here, we report crystal structure M. ESX-5-secreted PE25–PPE41 heterodimer...
The Type II Secretion System (T2SS) is a molecular machine that drives the secretion of fully-folded protein substrates across bacterial outer membrane. A key element in machinery secretin: an integral, multimeric membrane forms pore. We show three distinct T2SSs can be distinguished based on sequence characteristics their secretin pores. Detailed comparative analysis two these, Klebsiella-type and Vibrio-type, showed them to further by pilotin mediates transport assembly into have...
The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert host immune response. Despite its role disease very little known about architecture system. study characterizes structures soluble domains two conserved core components – EccB1 and EccD1. periplasmic domain consists 4 repeat a central domain,...
HypothesisAmong patients undergoing shoulder arthroplasty (SA), female would have worse outcomes than their male counterparts.MethodsA multicenter prospective cohort of 2364 (1365 and 999 patients) treated with total SA or reverse from 2007 to 2015 was retrospectively analyzed. Results were assessed using several validated outcome measures range-of-motion testing. A multivariable analysis identified differences in preoperative values, postoperative preoperative-to-postoperative improvements...
EccA1 is an important component of the type VII secretion system (T7SS) that responsible for transport virulence factors in pathogenic mycobacteria. has N-terminal domain unknown function and a C-terminal AAA+ (ATPases associated with various cellular activities) domain. Here we report crystal structure from Mycobacterium tuberculosis, which shows arrangement six tetratricopeptide repeats may mediate interactions secreted substrates. Furthermore, size shape suggest its orientation context...
This article was published in the Bulletin of World Health Organization [ © 2012 ] and definite version is available at : http://dx.doi.org/10.2471/BLT.11.092189 The Journal's website at: http://www.who.int/bulletin/volumes/90/3/11-092189.pdf
Fertility in dairy cows depends on ovarian cyclicity and uterine involution. Ovarian involution are delayed when there is dysbiosis (overgrowth of pathogenic bacteria). may involve a mechanism through which the microbiota affects as well transcriptome endometrium within involuting uterus. The hypothesis was that postpartum would be associated with status cow during first lactation sampled at 1, 5, 9 weeks postpartum. All were allowed to return without intervention until week 5 treated an...
A modular and scalable approach to pyrimidine- purine-containing constrained ethyl (cEt) nucleosides is demonstrated. Minimizing stereochemical adjustments protecting group manipulations, diacetone glucose converted two representative cEt via a functionalized, common intermediate. The retrosynthetic this complex class of drug precursors offers clear benefits over existing routes based on step count efficiency.
The rise of drug-resistant Mycobacterium tuberculosis lends urgency to the need for new drugs treatment (TB). identification a serine protease, mycosin protease-1 (MycP₁), as crucial agent in hydrolyzing virulence factor, ESX-secretion-associated protein B (EspB), potentially opens door options. Using crystal structure mycobacterial MycP₁ apo form, we performed an iterative ligand- and structure-based virtual screening (VS) strategy identify novel, nonpeptide, small-molecule inhibitors...
The acid-catalysed condensation of diphenylmethyleneamines with various α-hydroxyimino-ketones (1a–f) gave 2,2-diphenyl-2H-imidazole 1-oxides [(2a–f), and (8)]. These compounds react as nitrones lithium aluminium hydride, methylmagnesium iodide, dimethyl acetylenedicarboxylate. However, the reaction 4-methyl-2,2-diphenyl- 2,2,4-triphenyl-2H-imidazole 1 -oxides sodium borohydride corresponding 2H-imidazoles. Curtis rearrangement 5-methyl-2,2-diphenyl-2H-imidazole-4-carbonyl azide 3-oxide (6)...
Abstract Objectives To develop an objective, quantifiable assay for endometrial periglandular fibrosis (EPF) and correlate results with histologic ultrastructural changes in equine biopsy specimens. Sample Population Endometrial specimens from 70 mares 3 to 27 years old estrus. Procedure In a double-blinded study design, were graded histologically (modified Kenney classification) EPF inflammation. collagen volume fraction (%EPCVF) was determined by light microscopic image analysis of...
Abstract Background To describe a case of acetylcholinesterase inhibitor (AChEI) toxicosis with ventilatory failure that was successfully treated mechanical ventilation (MV). Key Findings A 7‐year‐old, female spayed German Short‐haired Pointer, presented acute onset ptyalism, generalized muscle tremors, and diarrhea. Physical examination findings included evidence muscarinic overstimulation in the parasympathetic nervous system (eg, diarrhea, lacrimation), nicotinic sympathetic...