A5043253851- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Parkinson's Disease Mechanisms and Treatments
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Muscle activation and electromyography studies
- Tactile and Sensory Interactions
- Motor Control and Adaptation
- Action Observation and Synchronization
- Organ and Tissue Transplantation Research
- Neuroscience of respiration and sleep
- Vagus Nerve Stimulation Research
- Autoimmune Neurological Disorders and Treatments
- Long-Term Effects of COVID-19
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Social Media and Politics
- School Choice and Performance
- Biotin and Related Studies
Dalhousie University
2021-2025
Universidad Veracruzana
2013-2024
Faculty (United Kingdom)
2024
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2015-2021
Universidad de Xalapa
2021
Western University
2016-2021
John Wiley & Sons (United States)
2021
Hudson Institute
2021
MIND Research Institute
2019
University of North Carolina at Chapel Hill
2013-2015
The first postnatal year is characterized by the most dramatic functional network development of human lifespan. Yet, relative sequence maturation different networks and impact socioeconomic status (SES) on their during this critical period remains poorly characterized. Leveraging a large, normally developing infant sample with multiple longitudinal resting-state magnetic resonance imaging scans (N = 65, scanned every 3 months), we aimed to delineate 9 key brain examine SES correlations. Our...
Abstract One important approach to human brain mapping is define a set of distinct regions that can be linked unique functions. Numerous parcellations have been proposed, using cytoarchitectonic, structural, or functional magnetic resonance imaging (fMRI) data. The intrinsic smoothness data, however, poses problem for current methods seeking compare different parcellations. For example, criteria simply within‐parcel between‐parcel similarity provide even random with high value. Furthermore,...
The conventional understanding of the cerebellum as a sole movement control center has become obsolete, given its role in various higher-order functions, including cognition, emotion, and social processing. As these functions emerge during infancy, it is logical to assume that cerebellum’s functional organization must evolve tandem or preemptively underpin functions. However, longitudinal development architecture crucial early years infant life remains largely unexplored, highlighting...
Friedreich ataxia (FRDA) is an inherited neurological disease defined by progressive movement incoordination. We undertook a comprehensive characterization of the spatial profile and evolution structural brain abnormalities in people with FRDA.A coordinated international analysis regional volume using magnetic resonance imaging data charted whole-brain profile, interindividual variability, temporal staging differences 248 individuals FRDA 262 healthy controls.The brainstem, dentate nucleus...
ABSTRACT Spinocerebellar ataxia type 7 (SCA7) is an autosomal‐dominant neurodegenerative disorder characterized by progressive and retinal dystrophy. It caused a CAG trinucleotide expansion in the ataxin7 gene. Anatomical studies have shown severe cerebellar degeneration region‐specific neocortical atrophy SCA7 patients. However, impact of neurodegeneration on functional integration remaining tissue still unknown. The aim this study was to examine connectivity abnormalities areas with...
Abstract Background Several neuropathological studies in spinocerebellar ataxia type 2 (SCA2) have revealed significant atrophy of the cerebellum, brainstem, sensorimotor cortex, and several regions frontal lobe. However, impact neurodegeneration on functional integration remaining tissue is unknown. To analyze clinical these changes, we correlated abnormal connectivity found SCA2 patients with their scores scales. obtain followed two approaches. In one used areas cerebellar gray matter as...
Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that selectively affect vulnerable neuronal populations in the cerebellum and other subcortical regions. While previous studies have reported subtype differences absolute amount degeneration specific regions interest, they failed to account for two important factors. First, did not control overall severity pattern, second, fully characterize spatial pattern each SCA subtype. Here, we provide systematic...
Spinocerebellar ataxia type 2 (SCA2) is a rare, inherited neurodegenerative disease characterized by progressive deterioration in both motor coordination and cognitive function. Atrophy of the cerebellum, brainstem, spinal cord are core features SCA2; however, evolution pattern whole-brain atrophy SCA2 remain unclear. We undertook multisite, structural magnetic resonance imaging (MRI) study to comprehensively characterize neurodegeneration profile SCA2. Voxel-based morphometry analyses 110...
Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant cerebellar ataxia, characterized by epilepsy, ataxic symptoms, and cognitive impairments linked to Cerebellar Cognitive Affective Syndrome (CCAS). The Scale (CCAS-S) has been developed identify CCAS across various pathologies. To determine whether patients with SCA10 exhibit using the CCAS-S, compare its effectiveness Montreal Assessment (MoCA). A secondary objective was evaluate effect of demographic clinical data on CCAS-S...
Spinocerebellar ataxia type 10 (SCA10) is a rare, inherited neurological disorder caused by an expansion of the non-coding ATTCT pentanucleotide repeat in ATAXIN gene. It characterized cerebellar and epilepsy. Previous research has demonstrated extensive white gray matter degeneration, particularly cerebellum. However, impact SCA10 mutation on functional connectivity (FC) remains unexplored. This study aimed to characterize intrinsic FC changes patients their relationship clinical...
Multiple lines of research provide compelling evidence for a role the cerebellum in wide array cognitive and affective functions, going far beyond its historical association with motor control. Structural functional neuroimaging studies have further refined understanding neuroanatomy anatomical divisions, highlighting need examination individual cerebellar subunits healthy variability neurological diseases. This paper presents standardized pipeline examining grey matter morphometry that...
Background Previous studies of SCA2 have revealed significant degeneration white matter tracts in cerebellar and cerebral regions. The motor deficit these patients may be attributable to the degradation projection fibers associated with underlying neurodegenerative process. However, this relationship remains unclear. Statistical analysis diffusion tensor imaging enables an unbiased whole-brain quantitative comparison proprieties vivo. Methods Fourteen genetically confirmed aged-matched...
Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant inherited neurodegenerative disorder. Several post-mortem and imaging studies have shown cerebellar brainstem atrophy. A number of used volumetric regional information to investigate the relationship between neurodegeneration severity. However, analysis can obscure specific location in which degenerative process affecting brain tissue, be crucial for development new target treatments this disease. Here...
Actions involving fine control of the hand, for example, grasping an object, rely heavily on sensory information from fingertips. Although integration feedback during execution individual movements is well understood, less known about use in skilled movement sequences. To address this gap, we trained participants to produce sequences finger a keyboard-like device over 4-day training period. Participants received haptic, visual, and auditory indicating occurrence each press. We then either...
Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder characterized by degeneration of the motor and visual systems. Besides neural deterioration, these patients also show functional connectivity changes linked to degenerated brain areas. However, it not known if there are in regions necessarily areas undergoing structural deterioration. Therefore, this study we have explored whole-brain SCA7 order find overall abnormal pattern disease. Twenty-six age-and-gender-matched healthy controls...
Abstract Spinocerebellar Ataxia Type 7 (SCA7) is a neurodegenerative disorder caused by cytosine‐adenine‐guanine (CAG) repeat expansion. It clinically characterized ataxia and visual loss. To date, little known about SCA7 cognitive impairments its relationship with grey matter volume (GMV) changes. The aim of this study was to explore patients’ performance in specific components auditory‐verbal neuropsychological tests correlate their scores genetic mutation, severity GMV. We assessed verbal...
Background Spinal cord damage is a feature of many spinocerebellar ataxias (SCAs), but well-powered in vivo studies are lacking and links with disease severity progression remain unclear. Here we characterise cervical spinal morphometric abnormalities SCA1, SCA2, SCA3 SCA6 using large multisite MRI dataset. Methods Upper (vertebrae C1–C4) cross-sectional area (CSA) eccentricity (flattening) were assessed data from nine sites within the ENIGMA-Ataxia consortium, including 364 people ataxic...