A5088090066- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Viral Infectious Diseases and Gene Expression in Insects
- Protein Degradation and Inhibitors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- COVID-19 and healthcare impacts
- Polyomavirus and related diseases
- Porphyrin Metabolism and Disorders
- Signaling Pathways in Disease
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Erythrocyte Function and Pathophysiology
- Neutropenia and Cancer Infections
- Chronic Kidney Disease and Diabetes
- Methemoglobinemia and Tumor Lysis Syndrome
Icahn School of Medicine at Mount Sinai
2024-2025
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2022-2024
Yale University
2021
The emergence of next generation sequencing and widespread use mutational profiling in acute myeloid leukemia (AML) has broadened our understanding the heterogeneous molecular basis disease. Since genetic become a standard practice, several driver mutations have been identified. Accordingly, novel targeted therapeutic agents developed are now approved for treatment subsets patients that carry FLT3, IDH1, IDH2 [1, 2]. these AML offers new modality therapy, shifts paradigms toward...
An incomplete understanding of the biology human kidney, including relative abundances and interactions between intrinsic immune cells, has long constrained development therapies for kidney disease. The small amount tissue obtained by renal biopsy previously limited ability to use patient samples discovery purposes. Imaging mass cytometry (IMC) is an ideal technology quantitative interrogation scarce samples, permitting concurrent analysis more than 40 markers on a single section. Using...
Myelofibrosis (MF) is a myeloproliferative neoplasm characterized by constitutional symptoms, progressive cytopenias, and splenomegaly. Activating mutations in the JAK/STAT pathway cytokine dysregulation driving bone marrow fibrosis extramedullary hematopoiesis underlie pathobiology of MF. While multiple JAK inhibitors are currently approved provide significant symptom improvement, these agents do not possess disease course modifying potential. Additionally, outcomes poor for patients who...
Abstract Background COVID‐19 infection delays therapy and in‐person evaluation for oncology patients, but clinic clearance criteria are not clearly defined. Methods We conducted a retrospective review of patients with at tertiary care center during the Delta Omicron waves compared strategies. Results Median by two consecutive negative tests was 32.0 days (Interquartile Range [IQR] 22.0–42.5, n = 153) prolonged in hematologic malignancy versus solid tumors (35.0 malignancy, 27.5 tumors, p...
Delayed graft function (DGF) affects over 25% of deceased donor kidney transplants (DDKTs) and is associated with increased cost, worsened outcomes, mortality. While approaches to preventing DGF have focused on minimizing cold ischemia, factors such as acute tubular injury can influence risk. There are currently no pharmacologic therapies modify risk or promote repair, in part due our incomplete understanding the biology preimplantation injury.We collected intraoperative, biopsies from 11...
Abstract Background CD34+ stem cells serve as the primary graft source for allogeneic transplants, with a minimum of 2–4 × 10 6 cells/kg needed engraftment. There are conflicting data on outcomes at high cell doses, studies limited by few patients receiving doses far above target. Study design and Methods In this retrospective, single‐center study hematologic malignancies who underwent matched unrelated donor we assessed engraftment, survival, relapse, graft‐versus‐host disease (GVHD)...
The June Hot Topics focuses on the challenges venetoclax regimens have faced in multiple myeloma trials.
Abstract Background: Axicabtagene ciloleucel (Axi-cel), a CD19 directed CAR T cell therapy, results in durable response subset of patients with relapsed/refractory large B lymphoma (LBCL) the absence persistent circulating cells. Aim: We postulated that long-term efficacy therapy depends on downstream triggering native immunity. performed single-cell transcriptomics longitudinal peripheral blood (PB) samples and RNAseq tumor from ZUMA 1 Axi-cel study. Methods: Single immunoprofiling (5’...
e18655 Background: Tobacco smoking increases risk of multiple malignancies, most notably lung cancer, and is a leading cause premature morbidity mortality. cessation counseling effective in assisting patients to quit improving health outcomes, but over one third smokers report receiving no by healthcare providers. In this study, we investigated rates tobacco education at ambulatory visits among with active malignancy. Methods: We identified current diagnosis malignancy using the National...
42 Background: COVID-19 presents a particular challenge in oncology, as in-person visits and treatments can be delayed during infection patients are at risk for prolonged viral shedding. Our center uses two consecutive negative PCR tests to return clinic. As vaccination rates increase, we questioned the need this strategy vs time-based clearance approach. Methods: We identified cancer who tested positive from 10/1/2021 3/31/2022 single tertiary care performed chart review under an...