A5057383921- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Glutathione Transferases and Polymorphisms
- Crystallization and Solubility Studies
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Garlic and Onion Studies
- Cancer therapeutics and mechanisms
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Adenosine and Purinergic Signaling
- Hops Chemistry and Applications
- Vaccine Coverage and Hesitancy
- Virology and Viral Diseases
- Organophosphorus compounds synthesis
- Autophagy in Disease and Therapy
- Click Chemistry and Applications
- Cannabis and Cannabinoid Research
- Advanced biosensing and bioanalysis techniques
- Fungal Plant Pathogen Control
- Porphyrin and Phthalocyanine Chemistry
- Synthesis of Tetrazole Derivatives
- Quinazolinone synthesis and applications
Narodowy Instytut Leków
2012-2024
National Institute of Public Health
2022-2024
Medical University of Lublin
2014-2016
Medical University of Warsaw
2012
Multiple in vitro tests are widely applied to assess the anticancer activity of new compounds, including their combinations and interactions with other drugs. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay is one most commonly used assays efficacy agents. However, it can be significantly influenced by compounds that modify cell metabolism reaction conditions. Therefore, several sometimes screen for potential majority drug evaluated only this single method. aim...
Twelve tricarbonyl Re( i ) complexes with bidentate 8-hydroxyquinolinato and monodentate diazole ligands were synthesized, characterized by scXRD, IR, NMR, UV-Vis methods, checked for antibacterial anticancer activity.
Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer. Nrf2 plays critical role in coordinating the cell defense system by initiating transcription of cytoprotective genes, including detoxification enzymes such as NAD(P)H quinone dehydrogenase 1 (NQO1) transport proteins ATP-binding cassette, subfamily C (CFTR/MRP). Recently, essential tumor development progression multidrug resistance cancer cells has been...
The aim of the study was to assess seroprevalence anti-SARS-CoV-2 antibodies among healthcare workers (HCW) before introduction vaccination, in selected areas Poland as well identify potential risk factors and estimate cumulative incidence COVID-19 infections this population.The authors conducted a sero-epidemiological, cross-sectional HCW 5 non-COVID-19 hospitals Poland. recruitment took place December 1-23, 2020, all at could volunteer into study. All persons were screened with rapid...
A series of previously unknown sulforaphane analogues with organofluorine substituents bonded to the sulfinyl sulfur atom, an isoselenocyanate moiety in place isothiocyanate group, central atom various oxidation states, and different numbers methylene groups alkyl chain were synthesized fully characterized. All new compounds tested for their biological properties vitro demonstrated much higher anticancer activity against two breast cancer cell lines than that shown by native sulforaphane; at...
Triple-negative breast cancer (TNBC) represents aggressive phenotype with limited treatment options due to the lack of drug targets. Natural compounds are extensively studied regarding their potential alter efficacy Among them sulforaphane - an isothiocyanate natural origin, was shown be a hormetic compound, that may exert divergent effects: cytoprotective or cytotoxic depending on its concentrations. Thus, aim this study determine effect low, dietary concentrations proliferation and...
Isothiocyanates (R-NCS) are sulphur-containing phytochemicals. The main source plants of the Brassicaceae family. best known plant-derived isothiocyanate is sulforaphane that has exhibited anticancer activity in both vivo and vitro studies. Recent attempts to expand their use cancer therapy involve combining them with standard chemotherapeutics order increase therapeutic efficacy. aim this paper determine impact its natural analog alyssin on well-known drug 5-fluorouracil. type drug-drug...
Combination therapy is based on the beneficial effects of pharmacodynamic interaction (synergistic or additive) between combined drugs substances. A considerable group candidates for treatments are natural compounds (e.g., isothiocyanates) and their analogs, which tested in combination with anticancer drugs. We effect treatment isothiocyanate 2-oxohexyl 5-fluorouracil colon prostate cancer cell lines. The type was described using Chou-Talalay method. cytostatic cytotoxic activities most...
The compounds 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (2) and 7-ethyl-9-(N-morpholino)methyl-10-hydroxycamptothecin (3) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-neoplastic effects on several tumor cell lines. Due these properties, the being considered for advancement preclinical development stage. To gain better insights into molecular mechanism with biological target, here, we conducted an investigation their interactions model...
Antimetabolites, especially 5-fluorouracil, are commonly used clinically to treat breast, colon, and other cancers. However, their side effects inefficiency in monotherapy have prompted further searches for new combinations. Thus, the anticancer effect of 5-fluorouracil (5-FU) sulforaphane analogue, 4-isoselenocyanato-1-butyl 4′-fluorobenzyl sulfoxide (ISC), were tested vitro vivo models triple-negative breast cancer (TNBC) as a option this treatment-resistant aggressive type cancer. A...
Mitochondria are cell energetic centers where ATP is produced. They also play a very important role in the PDT as intracellular sites of photosensitizer localization. Photosensitizers gathering mitochondria (like porphyrin derivatives used this work) more effective tumor destruction. Moreover, it was assumed that di-amino acid substituents attached to ring will strengthen effectivity interaction with membrane receptors examined cells. MTT assay performed investigate influence PP(Arg)(2) and...
AIM. The aim of the article is to present and assess epidemiological situation salmonellosis in Poland 2021, relation previous years. MATERIAL AND METHODS. assessment was made on basis individual data cases, entered by sanitary-epidemiological stations into EpiBaza System, outbreaks caused Salmonella bacilli from Registry Epidemic Outbreaks System (ROE), as well aggregated published annual bulletins "Infectious Diseases Poisoning Poland" (NIPH NIH – NRI, GIS, Warsaw), including information...
Three previously unknown sulforaphane analogues with triazaphosphaadamantane (PTA) or o-carborane substituents bonded to the central sulfinyl sulfur atom were synthesized. New compounds tested for their biological properties in vitro against breast and colon cancer cell lines.