A5073811155- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Free Radicals and Antioxidants
- Polymer Surface Interaction Studies
- Multiple Myeloma Research and Treatments
- Cancer therapeutics and mechanisms
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Protein Degradation and Inhibitors
- Crystallography and molecular interactions
- Glutathione Transferases and Polymorphisms
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Metal complexes synthesis and properties
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Adenosine and Purinergic Signaling
- Garlic and Onion Studies
Narodowy Instytut Leków
2015-2024
Warsaw University of Life Sciences
2023-2024
Institute of Biochemistry and Biophysics, Polish Academy of Sciences
2024
Medical University of Warsaw
2012
Multiple in vitro tests are widely applied to assess the anticancer activity of new compounds, including their combinations and interactions with other drugs. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay is one most commonly used assays efficacy agents. However, it can be significantly influenced by compounds that modify cell metabolism reaction conditions. Therefore, several sometimes screen for potential majority drug evaluated only this single method. aim...
Female breast cancer is the most deadly in women worldwide. The triple-negative subtype therapies, due to lack of specific drug targets, are still based on systemic chemotherapy with doxorubicin, which burdened severe adverse effects. To enhance therapeutic success and protect against toxicity, carriers or combination therapy being developed. Thus, an innovative liposomal formulation containing doxorubicin main nutraceutical, sulforaphane, has been anticancer efficacy safety proposed was...
Sulforaphane (SFN), a naturally occurring chemopreventive and anticancer agent, is nuclear factor, erythroid 2-like 2 (NFE2L2/Nrf2) inducer. Nrf2 plays critical role in coordinating the cell defense system by initiating transcription of cytoprotective genes, including detoxification enzymes such as NAD(P)H quinone dehydrogenase 1 (NQO1) transport proteins ATP-binding cassette, subfamily C (CFTR/MRP). Recently, essential tumor development progression multidrug resistance cancer cells has been...
Palladium(II) complexes attract great attention due to their remarkable catalytic and biological activity. In the present study X-ray characterization, UV-Vis Time-Dependent Density Functional Theory (TD-DFT) calculations for six PdCl2(XPy)2 (where: Py = pyridine; X H, CH3 or Cl) were applied in order investigate substituent effects on crystal structures electronic properties combine results with cytotoxic The of PdCl2(3-MePy)2, PdCl2(4-MePy)2 PdCl2(2-ClPy)2, have been described first time...
Sulforaphane-modified selenium nanoparticles can be prepared in a simple aqueous-phase redox reaction through reduction of selenite with ascorbic acid. The sulforaphane molecules present the mixture adsorb on nanoparticle surface, forming an adlayer. resulting conjugate was examined several physicochemical techniques, including microscopy, spectroscopy, x-ray diffraction, dynamic light scattering and zeta potential measurements. As shown vivo investigations rats, nanomaterial administered...
A series of previously unknown sulforaphane analogues with organofluorine substituents bonded to the sulfinyl sulfur atom, an isoselenocyanate moiety in place isothiocyanate group, central atom various oxidation states, and different numbers methylene groups alkyl chain were synthesized fully characterized. All new compounds tested for their biological properties vitro demonstrated much higher anticancer activity against two breast cancer cell lines than that shown by native sulforaphane; at...
Abstract Purpose: Dysregulation of one the three D-cyclin genes has been observed in virtually all multiple myeloma tumors. The mechanisms by which CCND2 is upregulated a set are not completely deciphered. We investigated role post-transcriptional regulation through interaction between miRNAs and their binding sites at 3′UTR overexpression myeloma. Experimental Design: Eleven cell lines 45 primary samples were included study. Interactions deregulated mRNA targets analyzed 3′UTR-luciferase...
Triple-negative breast cancer (TNBC) represents aggressive phenotype with limited treatment options due to the lack of drug targets. Natural compounds are extensively studied regarding their potential alter efficacy Among them sulforaphane - an isothiocyanate natural origin, was shown be a hormetic compound, that may exert divergent effects: cytoprotective or cytotoxic depending on its concentrations. Thus, aim this study determine effect low, dietary concentrations proliferation and...
Isothiocyanates (R-NCS) are sulphur-containing phytochemicals. The main source plants of the Brassicaceae family. best known plant-derived isothiocyanate is sulforaphane that has exhibited anticancer activity in both vivo and vitro studies. Recent attempts to expand their use cancer therapy involve combining them with standard chemotherapeutics order increase therapeutic efficacy. aim this paper determine impact its natural analog alyssin on well-known drug 5-fluorouracil. type drug-drug...
Many phosphorylated nucleoside derivatives have therapeutic potential, but their application is limited by problems with membrane permeability and intracellular delivery. Here, we prepared polypyrrole microvessel structures modified superparamagnetic nanoparticles for use as potential carriers of nucleotides. The microvessels were via the photochemical polymerization monomer onto surface aqueous ferrofluidic droplets. A complementary physicochemical analysis revealed that a fraction was...
Combination therapy is based on the beneficial effects of pharmacodynamic interaction (synergistic or additive) between combined drugs substances. A considerable group candidates for treatments are natural compounds (e.g., isothiocyanates) and their analogs, which tested in combination with anticancer drugs. We effect treatment isothiocyanate 2-oxohexyl 5-fluorouracil colon prostate cancer cell lines. The type was described using Chou-Talalay method. cytostatic cytotoxic activities most...
A new tetrahydroacridine derivative (CHDA) with acetylcholinesterase inhibitory properties was synthesized. Using a range of physicochemical techniques, it shown that the compound strongly adsorbs onto surface planar macroscopic or nanoparticulate gold, forming nearly full monolayer. The adsorbed CHDA molecules reveal well-defined electrochemical behavior, being irreversibly oxidized to electroactive species. also exhibits strong fluorescence, which is effectively quenched after adsorption...