A5101726980- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Agricultural Science and Fertilization
- Genetics and Plant Breeding
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Sesame and Sesamin Research
- Agricultural Economics and Practices
- Multicomponent Synthesis of Heterocycles
- Pharmacological Effects of Natural Compounds
- Quinazolinone synthesis and applications
- Agricultural Practices and Plant Genetics
- Nanoparticles: synthesis and applications
- Chemical synthesis and alkaloids
- Essential Oils and Antimicrobial Activity
- Rice Cultivation and Yield Improvement
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Livestock Management and Performance Improvement
- Synthesis of β-Lactam Compounds
- Nanoparticle-Based Drug Delivery
Siksha O Anusandhan University
2016-2025
Instituto Nacional de Enfermedades Respiratorias
2025
GITAM University
2024
University of Engineering & Management
2024
Institute of Medicinal Plant Development
2021
King's College Hospital
2020
Regional Medical Research Centre
2020
Institute of Medical Sciences and Sum Hospital
2020
Jawaharlal Nehru Technological University, Hyderabad
2019
Kingston University
1989
Nowadays, bacterial infections epitomize significant health threats globally with an increased morbidity and mortality. Most contemporary antibacterial agents are resisted by pathogenic bacteria - the multidrug resistant (MDR) strains arising from cross resistances operative in natural consortia inside human body environments. Consequently, development of newer potential drug candidate(s) is required against broad spectrum MDR bacteria. Indeed, phytochemical coumarin its derivatives had been...
Importance Cytokine storm (CS) is a hyperinflammatory syndrome causing multiorgan dysfunction and high mortality, especially in patients with malignant hematologic neoplasms. Triggers include neoplasm–associated hemophagocytic lymphohistiocytosis (MN-HLH), cytokine release from chimeric antigen receptor T-cell therapy (CAR-T CRS), COVID-19, but the underlying mechanisms of inflammation their impact on outcomes are poorly understood. Objective To delineate inflammatory patterns characterizing...
In the present research study, 3-heteroarylazo 4-hydroxy coumarin derivatives were synthesized and evaluated in vitro for their preliminary antibacterial activities against four different pathogenic bacterial strains such as Staphylococcus aureus, Escherichia coli, Bacillus subtilis Pseudomonas aeruginosa. Antibacterial activity of each compound was compared with standard drug, Ampicillin. The compounds interpreted by UV, IR, 1H NMR, mass spectroscopy X-ray diffraction studies....
The burden from microbial diseases has to be addressed in an increasing pace due multidrug resistance, causing clinical annoyance, globally. Indeed, employing eco-friendly approaches by green syntheses of nanoparticles with metals/metalloids as antibacterial compounds would continual and cost-effective. Herein, the synthesis silver (AgNPs) aqueous extracts cyanobacterium Chroococcus minutus (strain, CRLSUM10), collected meeting point sea river, East coast India, are presented; both reducing...
A huge number of plant-derived essential oils (EOs) are reported to have lots ethnomedicinal and biological properties with excellent antibacterial activities. Approximately three hundred EOs (ajowan, anise, basil, camphor, chamomile, clove, citronella, coriander, cumin, eucalyptus, lavender, lemon, orange, peppermint, thyme oils, etc.) documented under economic class based on commercial pharmaceutical values. However, most active crude their constituents like carvacrol, eugenol, geraniol,...
Abstract Leprosy (causative, Mycobacterium leprae ) continues to be the persisting public health problem with stable incidence rates, owing emergence of dapsone resistance that being principal drug in ongoing multidrug therapy. Hence, overcome resistance, structural modification through medicinal chemistry was used design newer derivative(s) (DDs), against folic acid biosynthesis pathway. The approach included theoretical modeling, molecular docking, and dynamic (MD) simulation as well...
The manifestation of bacterial UTI (Urinary Tract Infection) has been predominantly endemic, globally; eventually, the development new antibacterial agent(s) remains call day. Herein, two series Mannich-based 4-hydroxy coumarin derivatives, 7a-m and 8a-m were designed by suitable heterocyclic amines condensed with aldehydes. synthesised molecules interpreted 1H-NMR 13C-NMR spectral analyses in vitro studies. compound,...
Leprosy continues to be the belligerent public health hazard for causation of high disability and eventual morbidity cases with stable prevalence rates, even treatment by on-going multidrug therapy (MDT). Today, dapsone (DDS) resistance has led fear leprosy in more unfortunate people certain developing countries. Herein, DDS was chemically conjugated five phytochemicals independently as dapsone-phytochemical conjugates (DPCs) based on azo-coupling reaction. Possible biological activities...
Abstract The current study aimed to identify a new strategy of FeCl 3 catalyzed multicomponent synthesis substituted 2 H ‐chromene–fused pyrrole derivatives. A series chromene‐based prepared by employing an array 3‐nitro‐2 ‐chromenes, aniline, and acetylacetone in toluene under microwave irradiation. Using as prompt catalyst irradiation synthesize motifs significantly reduces the reaction time facilitates high yields (83%‐95%). Structure all synthesized compounds analyzed spectroscopic...
Abstract Molecules with potency and low toxicity are the leading army in battlefield of multidrug resistance. Quercetin is found abundance nature as a potent flavonoid bears tag paradox due to poor bioavailability, however, it still possess distinct systemic actions, this marks curiosity research field. The present study elaborates targeted silico simulation approaches newly designed quercetin analogs toward their anticancer antifungal properties by screening against human epidermal growth...
The increasing incidence of bacterial infections has led to rise in antimicrobial resistance (AMR), a significant concern public health across the globe. Henceforth, there is an urgency address AMR catastrophe, including developing new antibiotics, promoting appropriate use existing and investing more research development. Development potent antibiotic derivatives call day. Herein, we designed novel series ciprofloxacin joined with sulfa-drugs (CIS1-15) screened them against E. coli...