A5064975314- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Synthesis of Organic Compounds
- Malaria Research and Control
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Graphene and Nanomaterials Applications
- Cyclopropane Reaction Mechanisms
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Characterization of Pyrroles
- Chemical Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Computational Drug Discovery Methods
- Synthesis of Indole Derivatives
- Synthesis and Reactivity of Heterocycles
- Chemical Synthesis and Analysis
- HIV/AIDS drug development and treatment
- Peptidase Inhibition and Analysis
- Catalytic Alkyne Reactions
Ravenshaw University
2018-2024
National Institute of Pharmaceutical Education and Research
2024
Sri Sri University
2018
Abstract Smallest ring size, high strain, and more reactivity of cyclopropene have brought the attention researchers for chemical exploration. In this context, chemistry cyclopropenone has exponentially grown over last few years. This present review focuses on most recent developments in cyclopropane chemistry.
Abstract An organocatalyzed asymmetric Michael addition reaction has been established as the most relevant and dynamic research area for construction of chiral carbon‐carbon carbon‐heteroatom bond. In current scenario, rapid revolutions on to nitroolefins have explored by taking advantage newly developed organocatalysts. Moreover, proven well‐known acceptors providing various structurally essential nitro‐functionalized frameworks. this, remarkable stereoselectivity achieved in this process...
Abstract The current study aimed to identify a new strategy of FeCl 3 catalyzed multicomponent synthesis substituted 2 H ‐chromene–fused pyrrole derivatives. A series chromene‐based prepared by employing an array 3‐nitro‐2 ‐chromenes, aniline, and acetylacetone in toluene under microwave irradiation. Using as prompt catalyst irradiation synthesize motifs significantly reduces the reaction time facilitates high yields (83%‐95%). Structure all synthesized compounds analyzed spectroscopic...
A new series of novel chromene‐based oxadiazole derivatives were synthesized from a variety amidoximes with readily available carboxylic acids under conventional oil bath heating as well microwave irradiation. The use commercially EDCI and HOBt coupling reagents in DMF combined resulted high yields purities the product 1,2,4‐oxadiazoles an expeditious manner. This methodology is successfully applied to synthesize 18 numbers 2 H ‐chromene‐substituted 1,2,4‐oxadiazole good yields. structure...
A series of diverse 2′-oxo-6 b ,7,8,9-tetrahydro-6 H -spiro[chromeno[3,4- a ]pyrrolizine-11,3′-indoline]-6 (11 aH )-carbaldehyde derivatives are synthesized and antibacterial evaluation is done along with computational studies.
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Abstract An efficient one‐pot Michael addition‐cyclization reaction has been developed for the synthesis of 6 H ‐chromeno[4’,3’ : 4,5]imidazo[1,2‐a]pyridine under microwave irradiation method. The current protocol paves way twenty number structurally diversified imidazo[1,2‐ a ]pyridines in high yield by substituted 2‐aryl‐3‐nitro‐2 ‐chromenes with 2‐aminopyridines using anhydrous iron(III)chloride. This is first report preparation this medicinally significant highly derivatives good to...
ABSTRACT A highly efficient method for the synthesis of 2′ H ‐spiro[indene‐2,3′‐pyrano[2,3‐ c ]chromene] derivatives 20(a–s) has been developed involving oxa–Diels–Alder reaction as key step under conventional conditions in good to excellent yields. The compounds were all characterized using 1 H, 13 C NMR, HRMS, and X‐ray crystallography. present study employs DFT validate pathway. In vitro antibacterial assay synthesized was evaluated against Gram‐negative Escherichia coli Gram‐positive...
A series of flavone-stilbene-based hybrid molecules were synthesized in good to excellent yield (65–95%) via Heck coupling as the key step under conventional well microwave irradiation conditions. The advantages developed protocol involve short reaction time, high products obtained without use any additives and ability obtain pure compounds by recrystallization obviating need for time-consuming column chromatography. These evaluated their vitro anti-plasmodial activity against...
A novel green synthetic methodology has been developed to obtain enantiopure (2<italic>S</italic>)-2-<italic>C</italic>-spiro-glycosyl-3-nitrochromenes following the oxa-Michael–aldol condensation reaction of sugar derived 3-<italic>C</italic>-vinyl nitro olefins with substituted salicylaldehydes using Et<sub>3</sub>N as a base under neat conditions at rt–40 °C.
An efficient cross-coupling reaction between imidazo[1,2-a]pyridine derivatives and 6-bromoflavones has been well established. This proceeds through a Palladium-catalyzed to provide imidazo[1,2-a]pyridine-flavone hybrids in good excellent yield. Short time, high yield, wide substrate scope are the major advantages of this method. Using SYBR Green I assay, these hybrid molecules were examined for anti-plasmodial activity against Chloroquine-sensitive Pf3D7 Chloroquine-resistant PfK1 strains...
The current work reports the facile synthesis and characterization of a series diverse 2'-oxo-6b,7,8,9-tetrahydro-6H-spiro[chromeno[3,4-a]pyrrolizine-11,3’-indoline]-6a(11aH)-carbaldehyde derivatives following 1,3-dipolar cycloaddition reaction. This one-pot three-component involves 2H-chromene-3-carbaldehyde, isatin secondary amino acid (L-Proline/Pipecolinic acid) in ethanol to produce corresponding cycloadducts under conventional microwave irradiation. All synthesized compounds were...