A5101526914- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Multiple Myeloma Research and Treatments
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Trace Elements in Health
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- HIV/AIDS drug development and treatment
- Cell Adhesion Molecules Research
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Protease and Inhibitor Mechanisms
- Immune cells in cancer
- Sperm and Testicular Function
- Cancer Cells and Metastasis
- Cannabis and Cannabinoid Research
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Ginger and Zingiberaceae research
- Fungal Biology and Applications
- Transcranial Magnetic Stimulation Studies
Qiqihar Medical University
2022-2025
Jilin University
2024
Qujing Normal University
2024
South China Agricultural University
2016-2023
The University of Texas MD Anderson Cancer Center
2010-2023
Soochow University
2023
Southern Medical University
2022
Southeast University
2020
Hainan Medical University
2018
Yunnan University
2015
Early-phase trials targeting the T-cell inhibitory molecule programmed cell death ligand 1 (PD-L1) have shown clinical efficacy in cancer. This study was undertaken to determine whether PD-L1 is overexpressed triple-negative breast cancer (TNBC) and investigate loss of PTEN as a mechanism regulation. The Cancer Genome Atlas (TCGA) RNA sequencing data showed significantly greater expression gene TNBC (n = 120) compared with non-TNBC 716; P < 0.001). Breast tumor tissue microarrays were...
Preclinical data provide evidence for synergism between HER2-targeted peptide vaccines and trastuzumab. The efficacy of this combination was evaluated in patients with HER2 low-expressing breast cancer the adjuvant setting.A phase IIb, multicenter, randomized, single-blinded, controlled trial enrolled disease-free after standard therapy completion (NCT01570036). Eligible were HLA-A2, A3, A24, and/or A26+, had IHC 1+/2+, FISH nonamplified cancer, that node positive hormone receptor-negative...
To explore the effects of copper (Cu) on energy metabolism and AMPK-mTOR pathway-mediated autophagy in kidney, a total 240 one-day-old broiler chickens were randomized into four equal groups fed diets with different levels Cu (11, 110, 220, 330 mg/kg) for 49 d. Results showed that excess could induce vacuolar degeneration increase number autophagosomes adenosine triphosphate (ATP) level mRNA metabolism-related genes decreased increasing dietary level. Moreover, immunohistochemistry...
OBJECTIVE: To investigate the effect of combined scalp acupuncture and cognitive training on motor functioning in patients with stroke during recovery stage. METHODS: Seventy post-stroke impairment were rando
Copper poses huge environmental and public health concerns due to its widespread persistent use in the past several decades. Although it is well established that at higher levels copper causes nephrotoxicity, exact mechanisms of toxicity not fully understood. Therefore, this experimental study for first time investigates potential molecular including transcriptomics, metabolomics, serum biochemical, histopathological, cell apoptosis autophagy copper-induced renal pigs. A total 14 piglets...
Breast cancer is the most prominent among women worldwide, with a two-fold incidence in China compared to worldwide incidence. ALDH1A1, catalyzing oxidation of intracellular aldehydes and converting retinol into retinoic acid, serves as biomarker early stem cell differentiation. Ki67 levels are prognostic or residual risk biomarkers after primary therapy can predict effects systemic therapies monitor patients for sustained response resistance administered therapies. This study aimed...
Cross-presentation is an important mechanism by which exogenous tumor antigens are presented to elicit immunity. Because neutrophil elastase (NE) and proteinase-3 (P3) expression increased in myeloid leukemia, we investigated whether NE P3 cross-presented dendritic cells (DC) B cells, the source determines immune outcomes. We show that elevated leukemia patient serum levels correlate with remission status. demonstrate cellular uptake of into lysosomes, ubiquitination, proteasome processing...
Acetyl-L-carnitine (ALC) is an effective substrate for mitochondrial energy metabolism and known to prevent neurodegeneration attenuate heavy metal-induced injury. In this study, we investigated the function of ALC in recovery mouse spermatogonia cells (GC-1 cells) after heat stress (HS). The were randomly divided into three groups: control group, HS group (incubated at 42°C 90 min), + (treatment 150 μM incubated min). After stress, all recovered 37°C 6 h. content intracellular lactate...