A5004398591- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Atomic and Subatomic Physics Research
- Radiation Dose and Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Radiotherapy Techniques
- Lanthanide and Transition Metal Complexes
- MRI in cancer diagnosis
- Receptor Mechanisms and Signaling
- Renal cell carcinoma treatment
- Renin-Angiotensin System Studies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Computer Graphics and Visualization Techniques
- Renal and related cancers
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
University of Ottawa
2010-2024
Ottawa Heart Institute
2010-2020
Carleton University
2010-2019
International Commission on Radiological Protection
2010
Itron (United States)
2010
Oak Ridge Institute for Science and Education
2010
Library and Archives Canada
2010
Canadian Heritage
2010
Patient motion is a common problem during dynamic positron emission tomography (PET) scans for quantification of myocardial blood flow (MBF). The purpose this study was to quantify the prevalence body in clinical setting and evaluate with realistic phantoms effects on quantification, including CT attenuation correction (CTAC) artifacts that result from PET-CT misalignment.A cohort 236 sequential patients analyzed patient under resting peak stress conditions by two independent observers....
Elevation of the end-tidal partial pressure CO<sub>2</sub> (P<sub>ET</sub>co<sub>2</sub>) increases cerebral and myocardial blood flow (MBF), suggesting that it may be a suitable alternative to pharmacologic stress or exercise for perfusion imaging. The purpose this study was document pharmacodynamics MBF using prospective targeting precisely control arterial Pco<sub>2</sub> PET measure outcome variable, MBF. <b>Methods:</b> Ten healthy men underwent serial <sup>82</sup>Rb PET/CT Imaging...
We aimed to develop a framework for generating 3D myocardial blood flow (MBF) images, computing their accuracy against clinically validated 2D polar MBF maps of the left ventricle, and evaluating improvements in image quality over relative perfusion imaging (MPI). N=40 patients with wide range defect severities uptake dynamics were retrospectively studied. The FlowQuantTM software was used generate reference MPI adapted voxel-wise mapping. evaluated agreement between parametric vs. values at...
The negative developing machine recently installed by the Universal Pictures Corporation is an improved Spoor-Thompson Patent machine, manufactured Bennett Laboratories of Hollywood, who have exclusive rights manufacture.
Most physiologic effects of the renin angiotensin system (RAS) are mediated via (Ang) type 1 receptor (AT1R). The 18F-FPyKYNE derivative clinically used AT1R blocker losartan exhibits high binding selectivity for kidney and rapid metabolism in rats. aim this study was to further assess profile novel PET agent imaging rats pigs.In vitro assays were performed with 18F-FPyKYNE-losartan rat kidneys. Male Sprague-Dawley dosimetry, antagonistic efficacy blood pressure measurements, presence...
Ticagrelor is a P2Y12 receptor inhibitor used in acute coronary syndromes to reduce platelet activity and decrease thrombus formation. associated with reduction mortality incremental that observed clopidogrel, potentially related its non-antiplatelet effects. Evidence from animal models indicates ticagrelor potentiates adenosine-induced myocardial blood flow (MBF) increases. We investigated MBF at rest during hyperemia patients stable artery disease treated versus clopidogrel.This randomized...
Patient body motion is known to cause large deviations in the determination of myocardial blood flow (MBF) with errors exceeding 300%. Accurate correction for patient whole-body still a largely unsolved problem cardiac positron emission tomography (PET) imaging.This study evaluated efficacy using Natterer's formulation Helgason-Ludwig consistency conditions on two-dimensional Radon transform align computed PET projection data multiple time frames dynamic sequence purpose frame-by-frame rigid...
123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and radiodosimetry of this rotenone-like 123I-labeled tracer in microSPECT imaging-based study. 37 111 MBq was synthesized administered intravenously 14 healthy rats. Images were acquired with microSPECT/CT camera at various time intervals reconstructed allow activity quantification...
This paper describes an improved machine for developing motion picture negative films in use at the laboratories of Universal Pictures Corp. A thorough description and its operation is given. The system involves so-called reversal process.
Image reconstruction for positron emission tomography (PET) can be challenging and the resulting image typically has high noise. The kernel-based method [1], incorporates prior anatomic information in algorithm to reduce noise while preserving resolution. Prior is incorporated by means of spatial kernels originally used machine learning. In this paper, reconstruct PET images sympathetic innervation heart. are compared with standard Ordered Subset Expectation Maximization (OSEM) reconstructed...
Dynamic PET imaging is used to monitor the spatio-temporal distribution of a tracer in tissue region. can suffer from high noise; address this problem, kernel method has been developed for efficient dynamic image reconstruction. Previous approaches Gaussian exploit nonlocal spatial correlations priors. The kernel, an undesired effect smoothing frequencies. In work, we propose using wavelet with good energy compaction further enhance kernel-based oscillation result better representation...
Introduction: Ticagrelor is a reversible P2Y12 receptor antagonist used in patients with acute coronary syndrome (ACS). In the PLATO trial, treatment ticagrelor reduced mortality compared to clopidogrel, which pleotropic mechanisms may have contributed. this study, we effects of versus clopidogrel stable artery disease on myocardial blood flow (MBF) at rest and during intermediate high dose adenosine infusion. Methods: Patients (n=22) were randomized using double-blind crossover design 90 mg...