A5023525512- Reproductive tract infections research
- Wildlife Ecology and Conservation
- Animal Disease Management and Epidemiology
- Marine animal studies overview
- Gut microbiota and health
- Zoonotic diseases and public health
- Reproductive Physiology in Livestock
- T-cell and B-cell Immunology
- Microbial infections and disease research
- Plant and fungal interactions
- Herpesvirus Infections and Treatments
- Vector-borne infectious diseases
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Parasite Biology and Host Interactions
- Turtle Biology and Conservation
- Species Distribution and Climate Change
- Urinary Tract Infections Management
- Genetic and phenotypic traits in livestock
- Molecular Biology Techniques and Applications
- Cephalopods and Marine Biology
- Sperm and Testicular Function
- Viral Infections and Vectors
- Rangeland and Wildlife Management
- Genetic diversity and population structure
The University of Sydney
2016-2025
Fracture Analysis Consultants (United States)
2014
Sydney Local Health District
2014
Australian Museum
2014
University of Veterinary Science
2010
Australian Antarctic Division
2003
Taronga Conservation Society Australia
1997
To identify threats to the survival of koalas (Phascolarctos cinereus) in coastal New South Wales, Australia, we compared 3,781 admission records koalas, admitted between 1 January 1975 and 31 December 2004 a koala rehabilitation facility on midnorthern coast against local wild population demographics, with use multinomial logistic regression chi-square analyses. Trauma, most frequent reason for admission, affected young male animals more frequently than other groups. Seasonal differences...
Chlamydia pecorum is a globally recognised pathogen of livestock and koalas. To date, comparative genomics C. strains from sheep, cattle koalas has revealed that only single nucleotide polymorphisms (SNPs) limited number pseudogenes appear to contribute the genetic diversity this pathogen. No chlamydial plasmid been detected in these despite its ubiquitous presence almost all other species. Genomic analyses have not previously included porcine hosts. We sequenced genome three isolates pigs...
The major histocompatibility complex (MHC) is a dynamic genome region with an essential role in the adaptive immunity of vertebrates, especially antigen presentation. MHC generally divided into subregions (classes I, II and III) containing genes similar function across species, but different gene number organisation. Crocodylia (crocodilians) are widely distributed represent evolutionary distinct group among higher genomic organisation within this lineage has been largely unexplored. Here,...
Koala (Phascolarctos cinereus) populations are increasingly vulnerable and one of the main threats is chlamydial infection. retrovirus (KoRV) has been proposed as an underlying cause koala's susceptibility to infection with Chlamydia high rates lymphoid neoplasia; however, regionally ubiquitous, endogenous nature this virus suggests that KoRV A not sufficient for immune suppression occur. recently discovered exogenous variant KoRV, B, several structural elements increased pathogenicity in...
This study appraises recent research to critically evaluate knowledge on the factors that influence decisions around release of rehabilitated koalas fire‐affected home sites. Availability koala sites could be compromised at times in future by increasing incidence large and intense bushfires due climate change. In addition, such as fragmentation habitat urbanisation impose other threats long‐term survival released koala. Our investigation is conducted a Critically Appraised Topic (CAT) with...
The recent classification of the koala to endangered across most its range has emphasised urgent need for enhanced disease surveillance. Little is known about distribution and clinical significance phascolarctid gammaherpesvirus 2 (PhaHV-2) outside Australian states Victoria South Australia. PhaHV-2 may have significant impacts on wellbeing, justifying investigation into impact. To better characterise virus factors associated with infection, we developed a novel quantitative polymerase chain...
The pharmacokinetic profile of meloxicam in clinically healthy koalas ( n = 15) was investigated. Single doses were administered intravenously (i.v.) (0.4 mg/kg; 5), subcutaneously (s.c.) (0.2 1) or orally 3), and multiple to two groups via the oral s.c. routes 3 for both routes) with a loading dose 0.2 mg/kg day 1 followed by 0.1 s.i.d further days. Plasma concentrations quantified high‐performance liquid chromatography. Following i.v. administration, exhibited rapid clearance CL ) 0.44 ±...
Investigation of the immune response koala (Phascolarctos cinereus) is needed urgently, but has been limited by scarcity species-specific reagents and methods for this unique divergent marsupial. Infectious disease an important threat to wild populations koalas; most widespread these Chlamydial disease, caused Chlamydia pecorum pneumoniae. In addition, retrovirus (KoRV), which 100% prevalence in northern Australia, proposed as agent suppression that could explain koala's susceptibility...
To overcome shortcomings in discriminating Chlamydia pecorum strains infecting the koala (Phascolarctos cinereus) at local level, we developed a novel genotyping scheme for this pathogen to inform management fine-scale subpopulation level. We applied two geographically distinct populations New South Wales, Australia: Liverpool Plains and Southern Highlands South-west Sydney (SHSWS). Our method provides greater resolution than traditional multi-locus sequence typing, can be used monitor...
Koalas (n = 43) were treated daily for up to 8 weeks with enrofloxacin: 10 mg/kg subcutaneously (s.c.), 5 s.c., or 20 per os (p.o.); marbofloxacin: 1.0-3.3 p.o., p.o. s.c. Serial plasma drug concentrations determined on day 1 and again at approximately 2 weeks, by liquid chromatography. The median (range) maximum (C(max) ) enrofloxacin 0.83 (0.68-1.52) 2.08 (1.34-2.96) μg/mL the T(max) 1.5 h (1-2) respectively. Plasma of orally dosed marbofloxacin too low be quantified. Oral administration...
Govendir, M., Hanger, J., Loader, J. Kimble, B., Griffith, E., Black, L. A., Krockenberger, M. Higgins, D. P. Plasma concentrations of chloramphenicol after subcutaneous administration to koalas ( Phascolarctos cinereus ) with chlamydiosis. vet. Pharmacol. Therap. 35 , 147–154. Nine mature chlamydiosis, typically keratoconjunctivitis and/or urogenital tract infection, were treated daily injections at 60 mg/kg for 45 days (five koalas), or a shorter duration (four koalas). All initially...
The Australian koala is an iconic marsupial with highly specific dietary requirements distributed across heterogeneous environments, over a large geographic range. distribution and genetic structure of populations has been heavily influenced by human actions, specifically habitat modification, hunting translocation koalas. There currently limited information on population diversity gene flow at species-wide scale, or consideration to the potential impacts local adaptation. Using sampling...
Chlamydiosis is a significant disease affecting Eastern Australian koala (Phascolarctos cinereus) populations, impacting individual animal welfare and fecundity therefore influencing population dynamics. The aim of this study was to investigate the effect synthetic peptide vaccine based on 4 components Chlamydia pecorum major outer membrane protein (MOMP), over an 18-month period in severely impacted by chlamydiosis. Wild koalas were recruited into vaccination or placebo treatment group...
ABSTRACT Infection by Chlamydia pneumoniae or pecorum commonly causes chronic, fibrotic disease of the urogenital tracts female koalas. Studies humans have associated titers serum immunoglobulin G (IgG) against chlamydial hsp60 and hsp10 antigens with chronic infection, salpingeal fibrosis, tubal infertility. To determine whether a similar relationship exists in -infected koalas, samples were collected opportunistically from 34 wild koalas examined gross pathology histopathology, PCR,...
Although Chlamydia causes disease of the urethra and prostate male koalas, its impact on testis epididymis has not been examined. This study describes chronic-active granulomatous orchitis epididymitis with interstitial fibrosis associated infection by pecorum in 2 18 adult koalas being euthanized at a koala hospital, 8 which also had chlamydial prostatitis. By immunohistochemistry transmission electron microscopy, inclusions were demonstrated within Sertoli cells directly mild inflammation...
Chlamydiosis, the most common infectious disease in koalas, can cause chronic urogenital tract fibrosis and infertility. High titres of serum immunoglobulin G against 10 kDa 60 chlamydial heat-shock proteins (c-hsp10 c-hsp60) are associated with fibrous occlusion koala uterus uterine tube. Murine human studies have identified associations between specific major histocompatibility complex class II (MHCII) alleles or genotypes, higher c-hsp antibody levels chlamydia-associated In this study,...
Objective To document the application of diagnostics and treatments at one rehabilitation facility over 10 years their effects on recovery post‐release survival 88 koalas treated for chlamydiosis, to highlight associated wildlife care issues with potential significance animal welfare disease ecology. Design Using a retrospective analysis medical records, we identified risk factors successful release using logistic regression model descriptive statistics. Procedure We examined clinical...
Chlamydiosis is the most documented and serious disease of koalas, characterized by ocular, urinary, reproductive lesions. Since little attention has been paid to pathological effects this infection in male system, we aimed determine incidence severity pathology associated with chlamydial koalas submitted koala hospitals southeast Queensland. The entire tract from 62 sexually mature not suitable for rehabilitation was evaluated 677 tissue samples were collected histology,...