Despite the clinical benefits of aspirin, interindividual variation in response to this antiplatelet drug is considerable. The manifestation aspirin resistance (AR) frequently observed, although complex process remains poorly understood. While AR etiology likely be multifactorial, genetic factors appear preponderant. According several association studies, both genome-wide and candidate gene numerous SNPs cyclooxygenase, thromboxane platelet receptors-related genes have been identified as...

Ischaemic stroke (IS) and venous thromboembolism (VTE) are two forms of that, although distinct, seem to share numerous risk factors. Concerning genetic factors, while many VTE markers have been reported, inclusively by genome-wide association studies (GWAS), the identification validation determinants underlying IS pathogenesis challenging. Considering that shared biological pathways aetiological severity might be also influenced VTE-related variants. Thus, present study was designed analyse...

Patients with Ebstein's anomaly of the tricuspid valve may have right-to-left shunt at atrial level resulting in hypoxaemia, high haematocrit and hyperviscosity syndrome. The purpose this study was to assess results percutaneous closure patients anomaly.Records treated between January 2002 June 2010 were reviewed. Their condition before after (clinical data, oxygen saturation haematocrit) studied. During period nine selected treated. Ages ranged from six 67 years; seven male. Mean pulmonary...

Nondipper hypertensive patients have higher levels of platelet-to-lymphocyte ratio, a new studied inflammatory biomarker in primary hypertension. Furthermore, these risk cardiovascular morbidity and mortality. This study aimed to assess the relationship between ratio pattern (dipper vs nondipper) association major adverse events.A retrospective analysis was performed. One hundred fifty-three were included classified as dipper or nondipper according 24-hour ambulatory blood pressure...

Sarcoidosis is a systemic granulomatous disease. Renal involvement rare initial presentation of this Few articles on renal as an sarcoidosis have been published in the literature. A 26-year-old Caucasian woman presented with acute failure manifestation sarcoidosis. uncommon feature and it essential to establish fast correct diagnosis because early therapy avoids progression terminal failure.

A coronary fistula is a connection between one of the arteries and cardiac chamber or great artery. It rare defect usually occurs in isolation. Two-dimensional echocardiography has an important role diagnosis but CT angiography essential to delineate anatomy. Surgery traditional therapeutic approach percutaneous closure now recommended method, with excellent results few complications experienced centers.We describe our experience treatment 15 fistulas 12 patients 1996 2011. Eight (67%) were...

A coronary fistula is a connection between one of the arteries and cardiac chamber or great artery. It rare defect usually occurs in isolation. Two-dimensional echocardiography has an important role diagnosis but CT angiography essential to delineate anatomy. Surgery traditional therapeutic approach percutaneous closure now recommended method, with excellent results few complications experienced centers. We describe our experience treatment 15 fistulas 12 patients 1996 2011. Eight (67%) were...

Langerhans' cell histiocytosis is a proliferative histiocytic disorder of unknown cause originating from dendritic cells.The authors report case in 48-year-old man with multisystemic disease presentation, including liver involvement.Hepatic involvement an uncommon feature this rare and there no consensus on the most effective therapeutic approach.

Addison's disease is an endocrine disorder characterized by primary adrenal insufficiency due to various causes. Mycobacterium tuberculosis infection was a major cause in the past but rare nowadays. We describe patient admitted our hospital who diagnosed with tuberculous disease.Tuberculosis of developed countries and so diagnosis clinical challenge requires high index suspicion.Tuberculosis should always be considered as since treating active steroids alone may have serious...

Spontaneous bacterial peritonitis (SBP) is a common complication of cirrhosis. Identification poor prognosis predictors essential in disease approach. Medical records from patients admitted at our institution between January 2008 and December 2010 with spontaneous were retrospectively reviewed. Criteria assessed age, sex, presenting symptoms, risk factors, ascitic fluid characteristics, evolution during hospitalization, prophylaxis discharge re-admission. 42 (34 male, 8 female) included the...

A Pancoast tumor is a rare condition, representing 3% to 5% of all lung cancers. The particular location these lesions leads the invasion structures in thoracic inlet, causing constellation symptoms known as Pancoast-Tobias syndrome. Diagnosis can be challenging due their low prevalence and possibility being asymptomatic. Most tumors are non-small cell However, conditions might arise at same location, histologic confirmation relevant. We report case 45-year-old man admitted internal medicine...

<b>Introduction:</b> Spirometry plays a fundamental role in the evaluation of pulmonary function. In 2012, with publication Global Lungs Initiative (GLI) reference equations, discussion equations chosen by each laboratory was once again spotlight. <b>Aim:</b> The aim to compare FEV1 value from different available, namely European Community for Steel and Coal (ECSC) 71|83|93, National Health Nutrition Examination Survey (NHANES) III GLI. <b>Methods:</b> We retrospectively selected...

Background: The link between low-density lipoprotein cholesterol (LDL-C) and stroke risk remains controversial few studies have evaluated the effect of LDL-C after survival.Aims: We assessed hypothesis proposing on outcome patients under influence previous Aspirin Therapy.Methods: Associations outcomes. LDL stoke was using Kaplan-Meier methodology, log-rank test, Cox proportional hazard models Bootstrap Analysis.Results: In a cohort 342 cases, we observed that among with no record aspirin...

We thank Guazzi et al for their thoughtful comments regarding our article. 1Exertional oscillatory breathing (EOB) is recognized as an abnormal cardiopulmonary response in patients with heart failure.Although the precise pathophysiologic mechanism of EOB remains somewhat unclear, it considered to reflect deregulation mechanical and neural feedback control mechanisms system.Several studies have demonstrated that a strong, effort-independent predictor unfavorable outcome acquired...

Background: The acute fibrinoid and organizing pneumonia (AFOP) is an histopathological patern, characterized by the presence of intra-alveolar fibrin pneumonia. AFOP entity that can be either idiopathic or associated with several clinical conditions including infectious diseases, drug interactions, cancer. No specific treatment exists for but excellent response to steroid therapy has been observed. Case Presentation: A 55-year-old man was admited hospital diagnosis. He did not respond...