Diabetic retinopathy (DR) significantly impacts vision and quality of life in diabetic patients. This study aimed to evaluate multifocal electroretinogram (mfERG) changes long-term type 1 diabetes mellitus (T1DM) patients without clinical signs DR detect early functional retinal alterations. A prospective observational was conducted involving 46 eyes from 23 T1DM age-matched healthy controls. mfERG assessed using the RETI-port/scan21 following ISCEV protocols. exhibited decreased response...

Aims/Purpose: To assess longitudinal changes in the thickness of inner retinal layers long‐term evolution type 1 diabetes mellitus (DM1) patients without signs diabetic retinopathy (DR), evaluated using optical coherence tomography (OCT) at three time points over 14 years. Methods: A prospective study was conducted, including 33 eyes DM1 with 24 years disease and good glycaemic control (HbA1c). Patients had been previously 2009 2017. The total sample 2023 that did not develop DR consisted...

Aims/Purpose: Diabetic retinopathy (DR), a common complication of Diabetes Mellitus (DM), is the primary cause irreversible blindness among working‐age population, particularly affecting those with type 1 diabetes (DM1). This condition poses global health challenge. DR acknowledged as neurovascular disease, initially causing neurodegeneration in cells inner retina and glial cells, which leads to both structural functional changes. The study aimed identify early changes long‐standing DM1...

Aims/Purpose: Stargardt disease is the most common hereditary retinal dystrophy (HRD) affecting primarily cones, typically associated with an autosomal recessive inheritance pattern, mainly due to mutations in ABCA4 gene. New diagnostic techniques have been introduced such as OCT, OCTA, and autofluorescence (AF). In this context, multifocal electroretinogram (mfERG) has gained importance a tool. The aim of study correlate structural findings obtained through AF functional changes detected by...

Aims/Purpose: To compare macular sensitivity and retinal thickness in patients with long‐term type 1 diabetes mellitus (DM1) without signs of diabetic retinopathy (DR) after 5 years follow‐up. Methods: Thirty‐two eyes from 32 DM1 DR were included. All participants underwent a complete ophthalmological examination, including microperimetry to assess spectral domain optical coherence tomography (SD‐OCT) measure layer thicknesses focusing on inner layers (IRL). The data compared results prior...

Purpose: Describe the existing correlations between OCT‐Angiography (OCTA) and MAIA microperimetry in patients who have suffered a rhegmatogenous retinal detachment (RRD). Methods: We conducted cross‐sectional study comparing 65 eyes that primary RRD was successfully repaired by PPV SF6 with control group consisting of 136 eyes. All underwent comprehensive ophthalmologic examination, including OCTA microperimetry. Results: There were no differences groups terms age, sex, laterality studied...

Background: This research seeks to evaluate alterations in blood flow and structural features within the superficial (SCP) deep (DCP) retinal capillary plexuses, as well choriocapillaris (CC), patients with type 1 diabetes (DM1) who have no diabetic retinopathy (DR) over a period of 4 years. Additionally, study examines changes total inner thickness. Methods: A prospective, longitudinal analysis was conducted using optical coherence tomography (OCT) OCT angiography (OCTA), involving 25 eyes...

Objectives: In this study, the objective was to assess correlation between macular function and peripapillary retinal nerve fiber layer (pRNFL) thickness following successful rhegmatogenous detachment (RRD) surgery, as well subsequent recovery of visual acuity. Methods: This a cross-sectional study including 64 eyes from patients with RRD who underwent treatment 23G pars plana vitrectomy (PPV), endophotocoagulation sulfur-hexafluoride (SF6) were included compared control group consisting 136...

Abstract To assess full-field electroretinogram findings in long-term type 1 diabetes patients without diabetic retinopathy. Prospective study including 46 eyes of 23 with and age-matched healthy evaluated by the RETI-port/scan21 portable system RETeval following ISCEV guidelines. The average duration was 28.88 ± 8.04 years. In scotopic conditions, using RETI-port/scan21, showed an increase b-wave implicit time (IT) (p = 0.017) lowest stimuli; a diminished amplitude 0.005) mixed response,...

Accommodation mainly affects the lens, a structure of eyeball that degrades with age. The aim this work was to study morphological changes different ocular structures during accommodation, both in anterior pole and posterior pole, which may also be involved accommodation process.

Lighting studies that take into account the age of inhabitants an area and are related to circadian light difficult find. This study aims simplify a method approximately compute reaching retina based on photopic illuminance corneal plane considering optical density aging crystalline lens. As example this proposed method, calculations were performed with both D65 A standard illuminants, showing how spectral power distribution is modified by lens, mainly at short wavelengths. Due these...

Diabetic retinopathy (DR) is the most severe and frequent retinal vascular disease that causes significant visual loss on a global scale. The purpose of our study was to evaluate vascularization in superficial capillary plexus (SCP), deep (DCP) choriocapillaris (CC) changes foveal avascular zone (FAZ) by optical tomography angiography (OCTA) patients with type 2 diabetes mellitus (DM2) moderate DR but without diabetic macular oedema (DME). Fifty-four eyes DM2 (level 43 ETDRS scale) DME 73...

The increase in diabetic retinopathy (DR) prevalence demonstrates the need for determination of biomarkers assessing disease development to obtain an early diagnosis and stop its progression. We aimed analyse total retinal (RT) inner layer (IRL) thicknesses type 2 diabetes mellitus (DM2) patients correlate these results with sensitivity using swept-source OCT (SS-OCT) microperimetry. For this purpose, a 54 DM2 subjects moderate no signs macular oedema (DME) 73 age-matched healthy individuals...

To evaluate changes in pattern electroretinogram (pERG) and visual evoked potentials (pVEP) patients with long-lasting type 1 diabetes without diabetic retinopathy (DR). Prospective study involving 92 eyes divided into two groups. The group included 46 of 23 (T1DM); the control age-matched healthy subjects. pERG pVEP were assessed using RETI-port/scan21 recording software (version 1021.3.0.0). Mean age was 48 ± 9.77 years for 51.7 4.75 group. mean duration 28.88 8.04 years. HbA1c value 7.29...

Retinal morphology, specifically in its curvature, and ocular aberrations change when the eye adapts to different lighting conditions, including photopic, scotopic, mesopic, blue light, red light. Sixty healthy young subjects with refractive error less than ±4.00 D of sphere 3.00 cylinder, not suffering from accommodative problems, or systemic pathology, having used electronic devices half an hour before taken substances that alter retina during 2 h prior study were included. The adapted...

To study choroidal thickness (CT) in type 2 diabetes mellitus (DM2) patients with moderate diabetic retinopathy (DR) and to correlate changes retinal (RT) swept-source OCT (SS-OCT) compared healthy subjects.Fifty-four DM2 DR without macular edema (DME) 73 age-matched subjects were evaluated using SS-OCT measure total RT CT the nine areas of Early Treatment Diabetic Retinopathy Study (ETDRS) grid.The mean age was 64.06 ± 11.98 years 60.79 8.62 control groups, respectively. Total showed...

Background: To assess retinal and optical changes associated with near vision reading for different lighting conditions in electronic screens. Methods: Twenty-four young healthy subjects participated the study; an iPad Ebook were chosen as stimuli 5 min of task conditions. Central peripheral thicknesses macular ETDRS areas by coherence tomography analyzed. Results: Significant differences found between basal thickness after high illumination, N6 (p = 0.021) I6 0.049) areas, low illumination...

Aims/Purpose: To reduce the variability when performing manual segmentation of foveal avascular zone (FAZ) on retinal optical coherence tomography angiography (OCTA) images, and to find a new accurate FAZ delimitation criterion. Methods: Seventy‐three eyes from healthy subjects, 40 Type 1 diabetes mellitus (DM1) patients without diabetic retinopathy (DR) 54 2 (DM2) with moderate DR macular oedema (DME) were evaluated using OCTA. A was performed by different observers each OCTA image...

Purpose: The aim is to study the correlation between macular function measured by integrity assessment (MAIA) microperimetry and optic nerve (ON) evaluated ON optical coherence tomography (OCT) in patients undergoing surgery after RRD. Methods: Cross‐sectional unicentric including 64 eyes with RRD surgically treated compared 136 healthy eyes. All underwent an ophthalmological examination MAIA OCT according total retina (TR) protocol retinal fibre layer (RNFL) protocol. Results: Significant...

Aims/Purpose: To analyse optic nerve head (ONH) blood perfusion using optical coherence tomography angiography (OCTA) in Type 1 diabetes mellitus (DM12) patients without retinopathy and healthy control eyes. Methods: A total of 33 DM1 subjects diabetic (DR) 24 age‐matched individuals were assessed by OCTA to quantify radial peripapillary capillary (RPC) plexus density thickness the four areas ETDRS grid. Results: Mean ages 50.64 ± 9.05 for group 53.17 4.56 years group, with no differences...

Aims/Purpose: To compare macular sensitivity measured with microperimetry in patients Type 1 diabetes mellitus (DM1) without signs of diabetic retinopathy (DR) after 5 years follow‐up. Methods: Twenty‐six eyes from 26 long‐term DM1 DR were included. All participants underwent a complete ophthalmic examination including best corrected visual acuity (BCVA), intraocular pressure, fundoscopy, axial length and using integrity assessment (MAIA) microperimeter (Topcon Corporation, Tokyo, Japan)....

Aims/Purpose: To early evaluate local functional changes in the retina of long‐standing type 1 diabetic patients (DM1) without retinopathy (DR) through use multifocal electroretinogram (mfERG). Methods: 46 eyes DM1 DR and healthy subjects were studied. Eyes with previous history ocular diseases that could alter mfERG results excluded. Participants evaluated using RETIscan recording system by Roland, following standardized international guidelines International Society for Clinical...

Aims/Purpose: To assess changes in retinal capillary plexuses and choriocapillaris over 4 years' time long‐term Type 1 diabetic patients (DM1) without retinopathy (DR). Methods: Twenty‐four eyes of 24 DM1 with no DR lesions were examined by optical coherence tomography angiography (OCTA) a year follow‐up period. Vascular density (VD) both superficial deep (SCP, DCP) (CC) compared, as well foveal avascular zone (FAZ) area diameters. Results: Mean age was 46.84 ± 11.28 years the average...

Aims/Purpose: Low visual acuity (VA) in children requires meticulous investigation search of possible organic causes. Once an alteration the optic nerve (ON) has been detected, differential diagnosis is essential due to different prognosis and management each entity. Methods: We report case a 10‐year‐old black girl who went ophthalmologist for decreased VA left eye (LE) with no other history, signs or symptoms. On examination she had right (RE) 1 (Snellen decimal scale) 0.1 LE. No...