A5082300080- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Craniofacial Disorders and Treatments
- Tumors and Oncological Cases
- Cardiac Structural Anomalies and Repair
- Peroxisome Proliferator-Activated Receptors
- Developmental Biology and Gene Regulation
- Gene expression and cancer classification
- Advanced Biosensing Techniques and Applications
- Prenatal Screening and Diagnostics
- Fuel Cells and Related Materials
- Cardiovascular Function and Risk Factors
- Gene Regulatory Network Analysis
- Pancreatic function and diabetes
- Ectopic Pregnancy Diagnosis and Management
- Congenital Heart Disease Studies
- Mitochondrial Function and Pathology
- Assisted Reproductive Technology and Twin Pregnancy
- Pluripotent Stem Cells Research
Icahn School of Medicine at Mount Sinai
2021-2025
Mount Sinai Hospital
2024
Child Health and Development Institute
2021-2024
New York Stem Cell Foundation
2024
Ajanta Pharma (India)
2014
Craniofacial development depends on formation and maintenance of sutures between bones the skull. In sutures, growth occurs at osteogenic fronts along edge each bone, suture mesenchyme separates adjacent bones. Here, we perform single-cell RNA-seq analysis embryonic, wild type murine coronal to define its population structure. Seven populations E16.5 nine E18.5 comprise mesenchyme, cells, associated populations. Expression Hhip, an inhibitor hedgehog signaling, marks a mesenchymal distinct...
Abstract Cardiac Purkinje fibers form the most distal part of ventricular conduction system. They coordinate contraction and play a key role in arrhythmias. While many cardiac cell types can be generated from human pluripotent stem cells, methods to generate fiber cells remain limited, hampering our understanding biology system defects. To identify signaling pathways involved formation, we analyzed single data murine embryonic hearts compared trabecular cardiomyocytes. This identified...
ABSTRACT An adverse consequence of the widespread introduction assisted reproductive techniques has been an exponential increase in prevalence multifetal pregnancies (Botting et al 1987). Such are associated with increased risk miscarriage and perinatal death (Kiely 1992). One options management is embryo reduction to twins which a background pregnancy outcome (Evans 1995). The aim study was compare gestation at delivery birth weight surviving following those control group dichorionic...
Abstract Craniofacial development depends on proper formation and maintenance of sutures between adjacent bones the skull. In sutures, bone growth occurs at edge each bone, suture mesenchyme maintains separation them. We performed single-cell RNA-seq analyses embryonic, murine coronal suture. Analyzing replicate libraries E16.5 E18.5, we identified 14 cell populations. Seven populations nine E18.5 comprised mesenchyme, osteogenic cells, associated Through an integrated analysis with bulk...
SUMMARY Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease. A major caveat however is that they remain functionally structurally immature in culture, limiting their potential for disease modeling regenerative approaches. Here, we address the question of how different metabolic pathways can be modulated order induce efficient hPSC-CM maturation. We show PPAR signaling acts isoform-specific manner balance...