A5068174607- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
- Cervical Cancer and HPV Research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Hormonal Regulation and Hypertension
- RNA regulation and disease
- Ocular Diseases and Behçet’s Syndrome
- Ovarian cancer diagnosis and treatment
- Peroxisome Proliferator-Activated Receptors
- Infectious Diseases and Mycology
- Trace Elements in Health
- Parasitic infections in humans and animals
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic and Kidney Cyst Diseases
- Genetic Associations and Epidemiology
- Healthcare cost, quality, practices
- Diet and metabolism studies
- Viral-associated cancers and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism and Genetic Disorders
- Cholesterol and Lipid Metabolism
- Cerebrospinal fluid and hydrocephalus
University of Cape Town
2015-2025
Harare Institute of Technology
2018-2025
South African Medical Research Council
2022-2025
University of Zimbabwe
2018-2019
African Institute of Biomedical Science and Technology
2016
Abstract Tamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor‐positive breast cancer. Tamoxifen acts as prodrug, with its primary therapeutic effect mediated by principal metabolite, endoxifen. However, tamoxifen has complex pharmacokinetics involving several drug‐metabolizing enzymes and transporters influencing disposition. Genes encoding involved in disposition exhibit genetic polymorphisms which vary widely across world populations. This review highlights...
Despite the success of antiretroviral therapy in HIV treatment, cervical cancer remains a leading malignancy HIV-infected women. Additionally, co-infection by and HPV further accelerates development. There are limited studies on role host somatic variations infected HIV-negative women with cancer. Therefore, this study aimed to investigate compare genetic variation biopsies obtained from intraepithelial neoplasia 3 understand genomic landscape. The distribution types was also investigated...
Anophthalmia is the most severe ocular malformation inherited in an autosomal, X-linked, recessive, or dominant form. We report here use of whole exome sequencing (WES) to help clinical diagnosis familial anophthalmia Harare, Zimbabwe. A mother presented her two sons, who are half-brothers, at Eye, Ear, Nose, and Throat Institute, Ophthalmology Unit Upon examination, half-brothers were diagnosed with bilateral anophthalmia. The requested a genetic for sons. To segregate phenotype genotype,...
Parkinson's disease (PD) is a frequently occurring neurodegenerative motor disorder adversely impacting global health. There paucity of biomarkers and diagnostics that can forecast susceptibility to PD. A new research frontier for PD pathophysiology the study variations in microRNA (miRNA) expression whereby miRNAs serve as "upstream regulators" gene relation functioning dopamine neuronal pathways. Leucine-Rich Repeat Kinase 2 (LRRK2) studied Little known about ways which targeting LRKK2...
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet needs further development in resource-limited countries. While there an abundance of genetic association studies controlled medical settings, a paucity with naturalistic design real-life clinical practice patients comorbidities under multiple drug treatment regimens. African are often burdened communicable noncommunicable comorbidities, the application pharmacogenomics settings remains limited. Using warfarin...
In Africa, the burden of hypertension has been rising at an alarming rate for last two decades and is a major cause cardiovascular disease (CVD) mortality morbidity. Hypertension characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current guidelines recommend use antihypertensives belonging to following classes: calcium channel blockers (CCB), angiotensin converting inhibitors (ACEI), receptor (ARB), diuretics, β-blockers, mineralocorticoid antagonists (MRAs), manage hypertension....
Pharmacogenomics may improve patient care by guiding drug selection and dosing; however, this requires prior knowledge of the pharmacogenomics drugs commonly used in a specific setting. The aim study was to identify preliminary set pharmacogenetic variants important Southern Africa. We describe comorbidities 3997 patients from Malawi, South Africa, Zimbabwe. These cohorts were included pharmacogenomic studies anticoagulation, dyslipidemia, hypertension, HIV breast cancer. 20 topmost...
Introduction: Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set evaluate significance of variants CYP3A4/5, SLCO1B1 and ABCC2 on LPV African HIV-positive patients. Materials & methods: Eighty-six participants ritonavir (LPV/r) were genetically characterized determined. Results discussion: concentrations differed >188-fold (range 0.0206–38.6 µg/ml). Both CYP3A4*22 rs4149056G (c.521C) not observed this cohort. CYP3A4*1B,...
The use of pharmacogenomics (PGx) knowledge in treatment individual patients is becoming a common phenomenon the developed world. However, poorly resourced countries have thus far been constrained for three main reasons. First, cost whole genome sequencing still considerably high comparison to other (non-genomics) diagnostics developing world where both science and social dynamics create dynamic fragile healthcare ecosystem. Second, studies correlating genomic differences with drug...
Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role genetic variation RHTN among Africans. We set out investigate polymorphisms
Cysticercosis is a parasitic infection caused by the larvae of cestode
Pharmacogenomics may improve patient care by guiding drug selection and dosing, however this requires prior knowledge of the pharmacogenomics drugs commonly used in a specific setting. The aim study was to identify preliminary set pharmacogenetic variants important Southern Africa. We describe co-morbidities 3997 patients from Malawi, South Africa, Zimbabwe. These cohorts were included pharmacogenomic studies anticoagulation, dyslipidemia, hypertension, HIV, breast cancer. 20 topmost...
This study describes a restriction fragment polymorphism protocol for rapidly screening the SLCO1B1 c.1929A>C in genomic DNA samples. The has been associated with increased activity resulting hepatic uptake of drugs. Currently is genotyped using direct sequencing techniques and 5' nuclease based assays which can be cost prohibiting resource limited settings. aim this therefore was to design validate effective RFLP genotyping polymorphism. designed investigate effect on interindividual...
Aim: Investigate the role of host genetic variations in high-risk human papillomaviruses (HR-HPVs). Methods: This cross-sectional study recruited 238 cervical cancer patients. Variants transport (ABCC2), xenobiotic metabolism (GSTP, GSTT1, GSTM1, NQO1), DNA repair (ERCC1, XRCC1), immune response (TLR4) and apoptosis (CASP8, FASL, p53) genes were characterized. Tumor was genotyped for 14 HR-HPVs. Results: GSTP rs1695GG, XRCC1 rs1799782TT GSTT1 del/del associated with HPV51 (odds ratio [OR]:...