A5073859272- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Lipid Membrane Structure and Behavior
- Bacterial Identification and Susceptibility Testing
- Bacterial Genetics and Biotechnology
- Plant Micronutrient Interactions and Effects
- Cancer therapeutics and mechanisms
- Cellular transport and secretion
- Trace Elements in Health
- Evolution and Genetic Dynamics
- Porphyrin and Phthalocyanine Chemistry
UiT The Arctic University of Norway
2018-2023
Pennsylvania State University
2020-2021
Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development new antibiotics. Here, describe computational model (COMBAT-COmputational Model Bacterial Target-binding) that can quantitatively predict antibiotic dose-response relationships. Our goal dual: We address fundamental biological question investigate drug-target binding shapes action. create tool efficacy priori. COMBAT...
Microbial division rates determine the speed of mutation accumulation and thus emergence antimicrobial resistance. death are affected by antibiotic action immune system. Therefore, measuring these has advanced our understanding host-pathogen interactions action. Several methods based on marker-loss or few inheritable neutral markers exist that allow estimating microbial rates, each which advantages limitations. Technical bottlenecks, i.e., experimental sampling events, during experiment can...
Abstract Combatting antibiotic resistance will require both new antibiotics and strategies to preserve the effectiveness of existing drugs. Both approaches would benefit from predicting optimal dosing based on drug-target binding parameters that can be measured early in drug development change when bacteria become resistant. This avoid currently frequently employed trial-and-error might reduce number candidates fail late development. Here, we describe a computational model...
Abstract A significant challenge today within protein lipidology is to understand the relationship between cell structure, lipid membrane integrity, ion homeostasis and embedded proteins. The bacterial magnesium transporter (MgtA) a specialized P-type ATPase important for Mg 2+ import into cytoplasm; disrupted linked intrinsic ribosome instability nitro-oxidative stress in Salmonella strains. MgtA’s function highly dependent on anionic lipids, particularly cardiolipin, further...