A5061461854- Agricultural and Food Sciences
- Advancements in Transdermal Drug Delivery
- Crystallization and Solubility Studies
- Academic Research in Diverse Fields
- Healthcare Regulation
- Dental Implant Techniques and Outcomes
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Phytochemistry Medicinal Plant Applications
- Environmental and biological studies
- Analytical Chemistry and Chromatography
- Public Health in Brazil
- Contact Dermatitis and Allergies
- Science and Education Research
- Bee Products Chemical Analysis
- Analytical chemistry methods development
- Electrospun Nanofibers in Biomedical Applications
- Male Reproductive Health Studies
- Nail Diseases and Treatments
- Dermatologic Treatments and Research
- Surfactants and Colloidal Systems
- Healthcare during COVID-19 Pandemic
- Essential Oils and Antimicrobial Activity
- X-ray Diffraction in Crystallography
Universidade Federal de Ouro Preto
2019-2023
Universidade Federal da Bahia
2016-2018
Universidade Federal de Alfenas
2009-2018
The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining cutaneous administration of drugs. Despite this, large number bioactive compounds have successfully administered via because advances design topical transdermal formulations. In vitro vivo evaluations these novel drug delivery systems are necessary characterize their quality efficacy. This review covers most well-known methods for assessing absorption drugs as...
Apesar dos avanços da ciência, tem sido observada uma preocupação global quanto à crescente disseminação de microrganismos resistentes aos antibióticos. Objetivos: determinar a atividade antimicrobiana óleos essenciais Pinus sp. e Eucalyptus citriodora frente patógenos importância clínica Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa Candida albicans. Metodologia: análise caracterização fitoquímica os foi realizada pelo método cromatografia gasosa acoplada espectrometria...
Spironolactone (SPR) is a steroidal drug administered as potassium-sparing diuretic for high blood pressure treatment. The shows incomplete gastrointestinal absorption due to its poor aqueous solubility. physicochemical properties of SPR in crystal forms I and II suggest that differences their solubility may lead lack bioequivalence between solid-state formulations. In this study, polymorphs five batches active pharmaceutical ingredients (APIs) from three manufacturers were characterized...
The aim of this study was to develop and validate a method for evaluating the release skin permeation from transdermal nicotine patches using vertical diffusion cell (VDC). VDC is an experimental apparatus employed in research, development, pharmaceutical field because it can simulate conditions closest those established clinical trials. Two delivery systems marketed Brazil 14 mg over 24 hours were evaluated. Release studies carried out regenerated cellulose dialysis membrane excised porcine...
Glimepiride (GLIM) is used as an oral antihyperglycemic agent for treatment of type 2 diabetes. The drug presents two polymorphic forms (GLIM form I and GLIM II) described in the literature, according to vitro data, II about 3.5 times more soluble releases amount than physiological pH range. Considering literature data that diabetes demands glycemic control, avoiding abrupt fluctuations blood glucose levels, this work aimed study impact polymorphism vivo performance solid dosages. For this,...
O objetivo deste trabalho foi estudar a estabilidade intrínseca da donepezila em diferentes condições de estresse forçado (meios ácido, alcalino e oxidante, exposição à luz ao calor seco).A seus produtos degradação meio ácido foram separados detectados usando cromatografia líquida alta eficiência (HPLC) acoplada espectrometria massas HPLC detector arranjo diodos.Após sete dias, recuperação do fármaco hidróxido sódio 0,1 mol L -1 aproximadamente 42%, sendo três degradação, enquanto que...
A high performance liquid chromatography (HPLC) method has been developed for a rapid determination of nimesulide in dissolution studies.Nimesulide was analyzed using 5 µm Lichrospher® RP-18 column (125 x 4 mm i.d.) and mobile phase acetonitrile: phosphate buffer pH=6.0 (55:45) at flow-rate 1.0 mL min -1 .Detection carried out 300 nm 25 °C.The applied to analysis vitro release studies showed efficient analytical alternative evaluation profile nimesulide.
We propose to evaluate the dissolution properties of rosuvastatin calcium (ROSC) capsules in different media characterize discriminatory power assay method. Dissolution assays were performed with pH, and including surfactant sodium dodecyl sulfate (SDS). Several immediate-release formulations manufactured using commercial raw material characterized as amorphous solid. The hydrophobic adjutant magnesium stearate was employed some due its negative effect wettability efficacy solid dosages....