A5015276785- Opioid Use Disorder Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Substance Abuse Treatment and Outcomes
- Prenatal Substance Exposure Effects
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Sex work and related issues
- HIV-related health complications and treatments
- Hepatitis C virus research
- Platelet Disorders and Treatments
- Mental Health Treatment and Access
- Assisted Reproductive Technology and Twin Pregnancy
- HIV Research and Treatment
- Pain Management and Opioid Use
- Sexuality, Behavior, and Technology
- Pharmaceutical Practices and Patient Outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Treatment of Major Depression
- Adolescent Sexual and Reproductive Health
- Sperm and Testicular Function
- Autoimmune Bullous Skin Diseases
- Food Security and Health in Diverse Populations
- Immunodeficiency and Autoimmune Disorders
- Birth, Development, and Health
National Institute on Aging
2022-2023
National Institute on Drug Abuse
2010-2022
National Institutes of Health
2011-2022
Universidad Católica de Santiago de Guayaquil
2016
Emmes (United States)
2015
VA Puget Sound Health Care System
2014
Universidad San Francisco de Quito
2014
Treatment Research Institute
2014
AIDS Clinical Trials Group
2010
Leuven Institute for Fertility and Embryology
2003
<h3>Context</h3>No randomized trials have examined treatments for prescription opioid dependence, despite its increasing prevalence.<h3>Objective</h3>To evaluate the efficacy of brief and extended buprenorphine hydrochloride–naloxone hydrochloride treatment, with different counseling intensities, patients dependent on opioids.<h3>Design</h3>Multisite, clinical trial using a 2-phase adaptive treatment research design. Brief (phase 1) included 2-week buprenorphine-naloxone stabilization,...
Abstract Aims To examine patient and medication characteristics associated with retention continued illicit opioid use in methadone ( MET ) versus buprenorphine/naloxone BUP treatment for dependence. Design, settings participants This secondary analysis included 1267 opioid‐dependent individuals participating nine programs between 2006 2009 randomized to receive open‐label or 24 weeks. Measurements The analyses measures of at baseline (demographics; alcohol, cigarettes drugs; self‐rated...
This retrospective study aimed to evaluate the prognostic value of inseminating motile count (IMC) and sperm morphology (using strict criteria) on success rates after homologous intrauterine insemination (IUI) combined with clomiphene citrate (CC) stimulation. A total 373 couples underwent 792 IUI cycles in a predominantly (87.4%) male subfertility group. The overall cycle fecundity (CF) baby take-home rate (BTH) was 14.6 9.9% respectively. cumulative CF BTH (per couple) three were 30.6...
Objectives: Compare HIV injecting and sex risk in patients being treated with methadone (MET) or buprenorphine–naloxone (BUP). Methods: Secondary analysis from a study of liver enzyme changes randomized to MET BUP who completed 24 weeks treatment had 4 more blood draws. The initial 1:1 randomization was changed 2:1 (BUP:MET) after 18 months due higher dropout BUP. Risk Behavior Survey measured before 30 days at baseline 12 24. Results: Among 529 MET, 391 (74%) were completers; among 740 BUP,...
This study examines the barriers and facilitators of retention among patients receiving buprenorphine/naloxone at eight community-based opioid treatment programs across United States. Participants (n = 105) were recruited up to three a half years after having participated in randomized clinical trial comparing effect methadone on liver function. Semi-structured interviews conducted with 67 provided who had terminated early 38 completed least 24 weeks trial. Qualitative data analyzed using...
The application of digital technologies to better assess, understand, and treat substance use disorders (SUDs) is a particularly promising vibrant area scientific research. National Drug Abuse Treatment Clinical Trials Network (CTN), launched in 1999 by the U.S. Institute on Abuse, has supported growing line research that leverages glean new insights into SUDs provide science-based therapeutic tools diverse array persons with SUDs.This manuscript provides an overview breadth impact conducted...
Background and Objectives Induction is a crucial period of opioid addiction treatment. This study aimed to identify buprenorphine/naloxone (BUP) induction patterns examine their association with outcomes (opioid use, retention, related adverse events [AEs]). Methods The secondary analysis opioid‐dependent adults seeking treatment in eight settings included 740 participants inducted on BUP flexible dosing. Results Latent class models detected six distinctive trajectories: bup1‐started...
Under the Affordable Care Act, hospitals receive reduced reimbursements for excessive 30-day readmissions. However, Centers Medicare and Medicaid Services does not consider social behavioral variables in expected readmission rate calculations, which may unfairly penalize systems caring socially disadvantaged patients, including patients with HIV.Randomized controlled trial of patient navigation or without financial incentives HIV-positive substance users recruited from inpatient setting at...
Cell-free and cell-associated human immunodeficiency virus cultures suspended in 10% serum remained infectious for several weeks at room temperature. The stability was further increased when neat serum. When dried onto a glass coverslip, days, although lost infectivity more rapidly than cell-free virus.
Opioid agonist medications for treatment of opioid use disorder (OUD) can improve human immunodeficiency virus (HIV) outcomes and reduce use. We tested whether outpatient antagonist with naltrexone could achieve similar results.
Regional variability in human immunodeficiency virus (HIV) care engagement remains underexplored. Multiple logistic models compared HIV outcomes for participants from 5 Southern (n = 557) and 6 non-Southern 670) sites. were less likely to experience viral suppression (adjusted odds ratio [aOR], 0.52; 95% confidence interval [CI], .37-.72) had a higher likelihood of CD4+ count <200 cells/µL (aOR, 1.53; CI, 1.17-2.00). intervention social safety net programs should be expanded.NCT01612169.
Social media sites, dating apps, and information search sites have been used to reach individuals at high risk for HIV infection. However, it is not clear which platform the most efficient in promoting home self-testing, given that users of various platforms may different characteristics impact their readiness testing.This study aimed compare relative effectiveness social self-testing among minority men who sex with (MSM) an increased Test kit order rates were as a proxy evaluate promotion...
The US overdose epidemic is an escalating public health emergency, accounting for over 100,000 deaths annually. Despite the availability of medications opioid use disorders, provider-level barriers, such as negative attitudes, exacerbate treatment gap in clinical care settings. Assessing prevalence and intensity provider stigma, defined perceptions behaviors that providers embody enact toward patients with substance across different specialties, critical to expanding delivery treatment.To...
Persons living with HIV (PLWH) substance use disorders (SUD) remain a population difficult to engage in care. Project HOPE (Hospital Visits as an Opportunity for Prevention and Engagement), randomized controlled trial testing patient navigation with/without contingency management PLWH SUD, aimed address this disparity. SUD who were out of care recruited from 11 hospitals across the United States 2012 2014. Baseline socioeconomic factors, medical mistrust scores, perceived discrimination...
Most treatment studies of opioid-dependent populations have focused predominantly on heroin users, despite a recent increase in those dependent upon prescription opioids. A key methodological challenge involved studying the latter group involves defining population. Specifically, researchers must decide whether to include (1) concurrent users and (2) individuals with pain. The multi-site Prescription Opioid Addiction Treatment Study is examining treatments for this This paper describes...
Abstract Background There is growing public health concern around the potential impact of opioid crisis on efforts to eradicate HIV. This secondary analysis seeks determine if those who report opioids as their primary problem drug compared other drugs and/or alcohol differ in engagement HIV care among a sample hospitalized people with (PWH) use alcohol, traditionally marginalized and difficult engage population key ending epidemic. Setting participants A total 801 (67% male; 75% Black,...