A5034463576- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Click Chemistry and Applications
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Fetal and Pediatric Neurological Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Hedgehog Signaling Pathway Studies
- Genomics and Chromatin Dynamics
- Genetic and Kidney Cyst Diseases
- HVDC Systems and Fault Protection
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
University of Campania "Luigi Vanvitelli"
2022-2024
Telethon Institute Of Genetics And Medicine
2022
Heidelberg University
2021
University Hospital Heidelberg
2021
Abstract Background The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovered chromatin readers involved leukemogenesis may thus provide new anticancer strategies. Accumulating evidence suggests that PRC1 complex member CBX2 is overexpressed solid tumors promotes cancer cell survival. However, its role leukemia still unclear. Methods We...
We have recently developed a new synthetic methodology that provided both N-aryl-5-hydroxytriazoles and N-pyridine-4-alkyl triazoles. A selection of these products was carried through virtual screening towards targets are contemporary validated for drug discovery development. This study determined number potential structure target dyads which N-pyridinium-4-carboxylic-5-alkyl triazole displayed the highest score specificity KAT2A. Binding affinity tests abovementioned related analogs KAT2A...