A5075679870- Ultrasound and Hyperthermia Applications
- Cellular Mechanics and Interactions
- Microfluidic and Bio-sensing Technologies
- 3D Printing in Biomedical Research
- Fluid Dynamics and Mixing
- Minerals Flotation and Separation Techniques
- Ultrasound and Cavitation Phenomena
- Molecular Biology Techniques and Applications
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Photoacoustic and Ultrasonic Imaging
- Innovative Microfluidic and Catalytic Techniques Innovation
- Characterization and Applications of Magnetic Nanoparticles
University of Leeds
2018-2023
Mansoura University
2021
Lipid-shelled nanobubbles (NBs) are emerging as potential dual diagnostic and therapeutic agents. Similar to their micron-scale counterparts, microbubbles (1-10 μm), they can act ultrasound contrast agents well locally enhance uptake. Recently, it has been shown that the reduced size of NBs (<1 μm) promotes increased uptake accumulation in tumor interstitial space, which performance. However, accurate characterization NB concentration is challenging may limit translation into clinical use....
Abstract Label‐free live single‐cell Raman spectroscopy was used to obtain a chemical fingerprint of colorectal cancer cells including the classification SW480 and SW620 cell line model system, derived from primary secondary tumour same patient. High‐quality spectra were acquired hundreds cells, showing high reproducibility between experiments. Principal component analysis with linear discriminant yielded best classification, an accuracy 98.7 ± 0.3% (standard error) when compared...
Microbubbles (MBs) have a multitude of applications including as contrast agents in ultrasound imaging and therapeutic drug delivery vehicles, with further scope for combining their diagnostic properties (known theranostics). MBs used clinically are commonly made by mechanical agitation or sonication methods, which offer little control over population size dispersity. Furthermore, yet to be therapeutically research is needed develop these theranostic agents. In this paper, we present our MB...
Lipid-shelled microbubbles (MBs) offer potential as theranostic agents, capable of providing both contrast enhancement in ultrasound imaging well a route for triggered drug release and improved localized delivery. A common motif the design such therapeutic vehicles is attachment carrier, often form liposomes, to microbubble. Traditionally, attachments have been based around biotin–streptavidin maleimide–PDP chemistries. Comparatively, use DNA–lipid tethers offers advantage. First, their...
Abstract Disease can induce changes to subcellular components, altering cell phenotype and leading measurable bulk-material mechanical properties. The phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic their response an applied stress is highly dependent on the magnitude timescale actuation. Microfluidics be used measure deformability over a wide range flow conditions, operating two distinct regimes (shear inertial) which expose subtle...