A5058178737- Cancer Genomics and Diagnostics
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Estrogen and related hormone effects
- HER2/EGFR in Cancer Research
- Patient Satisfaction in Healthcare
- Telemedicine and Telehealth Implementation
- Cardiac Arrest and Resuscitation
- Primate Behavior and Ecology
- Radiomics and Machine Learning in Medical Imaging
- Single-cell and spatial transcriptomics
- Pancreatic and Hepatic Oncology Research
- Image Processing Techniques and Applications
- Bacteriophages and microbial interactions
- Prenatal Substance Exposure Effects
- Traumatic Brain Injury Research
- Lung Cancer Treatments and Mutations
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiopharmaceutical Chemistry and Applications
- Cell Image Analysis Techniques
- Microbial Community Ecology and Physiology
- Cervical Cancer and HPV Research
- Healthcare Systems and Technology
- Cancer-related Molecular Pathways
- Colorectal and Anal Carcinomas
Michigan Medicine
2025
University of California, Berkeley
2004-2024
Museum of Vertebrate Zoology
2024
Garvan Institute of Medical Research
2019-2024
UNSW Sydney
2015-2024
St George Hospital
2016-2024
St Vincent's Hospital Sydney
2023
The Kinghorn Cancer Centre
2019-2023
University of Michigan
2021-2022
Johns Hopkins University
2022
Rosacea is a common, chronic skin disease that currently incurable. Although environmental factors influence rosacea, the genetic basis of rosacea not established. In this genome-wide association study, discovery group 22,952 individuals (2,618 cases and 20,334 controls) was analyzed, leading to identification two significant single-nucleotide polymorphisms (SNPs) associated with one which replicated in new 29,481 (3,205 26,262 controls). The confirmed SNP, rs763035 (P=8.0 × 10(-11) group;...
Most health insurance organizations reimbursed both video and audio-only (i.e., phone) visits during the COVID-19 pandemic, but may discontinue phone visit coverage after pandemic. The impact of discontinuing on various patient subgroups is uncertain. Identify that are more probable to access telehealth through versus video. Retrospective cohort. All patients at a U.S. academic medical center who had an outpatient was eligible for from April June 2020. marginal cumulative effect demographic,...
This study determined the influence of prematurity on manifestation and treatment neonatal abstinence syndrome (NAS).This was a medical record review Australian infants exposed to opiates in 2004 2007. Finnegan scores were obtained for 215 361 (59%) preterm under 37-week gestation 694 1178 term infants.The mean standard deviation (SD) gestational ages 34 (3) 38 weeks infants, respectively. Maternal daily methadone doses similar with 79 mg (39) versus 72 (38) (p = 0.06). Maximum significantly...
Abstract Background Despite the dramatic increase in volume of electronic health record (EHR) inbasket work, most organizations have not provided additional time to attend this asynchronous care delivery. Aim To improve physician well-being and reduce spent EHR outside work by providing structured during workday address workload. Setting An academic system Midwest. Participants Physicians general medicine pediatrics with ≥ 1 half-day clinic per week. Program Description Implementation one...
Abstract We report a genomics‐guided exploration of the metabolic potential brasilicardin producer strain Nocardia terpenica IFM 0406. Bioinformatics analysis whole genome sequence revealed presence biosynthetic gene cluster presumably responsible for generation formerly unknown nocobactin derivatives. Mass spectrometry‐assisted isolation led to identification three new siderophores, terpenibactins A ( 1 ), B 2 ) and C 3 which belong class nocobactins. Their structures were elucidated by...
Aim To determine the short‐term outcomes of Australian buprenorphine‐exposed mother/infant dyads. Methods Retrospective record review drug‐exposed mothers and infants in A ustralia. Groups were based on drug exposure: buprenorphine (55, 3.8%), non‐buprenorphine opiates ( O , 686, 48.6%) non‐opiates NO 671, 47.5%). Results More than 30% continued to use heroin (21, 38%) benzodiazepines (16, 29%). They more likely have child at risk concerns (29, 52.7%, P = 0.019) previous children placed...
Electronic consultations (eConsultations) are increasingly used to obtain specialist guidance, avoiding unnecessary face-to-face patient visits for certain clinical questions. During the COVID-19 pandemic, when in-person care was limited, eConsultations may have helped clinicians input guide care.To understand how use of changed during pandemic and whether trends in eConsultation utilization differed based on patient's payer primary language.This retrospective cohort study conducted at 6...
Examine initial feasibility and utility of a battery measures administered via telephone interview with caregiver for describing long-term outcomes in individuals history disorders consciousness (DoC) after pediatric acquired brain injury (ABI).Cross-sectional.Caregiver telephone.Convenience sample admitted to an inpatient neurorehabilitation unit DoC ABI at least 1 year prior assessment (n = 41, 5-22 yr old assessment).None.The Vineland Adaptive Behavior Scales, Third Edition (Vineland-3),...
Abstract: Leptomeningeal carcinomatosis (LMC) is a terminal event in advanced cancer, its incidence epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) increasing due to recent advances systemic therapy and prolongation of survival. Osimertinib third generation EGFR-tyrosine kinase inhibitor (TKI) with preclinical early clinical studies showing activity against LMC resistant previous TKI treatments acquired T790M mutation. We report case osimertinib the...
Abstract Advances in human epidermal growth factor receptor 2 (HER2)‐directed therapies have revolutionised the care of patients with HER2‐positive breast cancer. While adjuvant trastuzumab combination chemotherapy has dramatically improved prognosis for early‐stage disease, up to a quarter will develop recurrent disease. The standard‐of‐care treatment paradigm evolved introduction newer HER2‐directed and increasing use neoadjuvant systemic therapy, latter providing us important functional...
Taxane-based chemotherapy regimens are in widespread use as standard of care treatment for patients with early breast cancer, though rarely its can be complicated by taxane-induced pneumonitis (TIP). While cancer is the most diagnosed women worldwide, TIP remains under-described this setting. Key questions relate to incidence, diagnosis and management, potential predictive biomarkers, balance between life-threatening toxicity curatively intended treatment. At a single Australian institution,...
18 F-Fludeoxyglucose PET-CT (FDG) is increasingly used to stage breast cancer. Most cancers express the Oestrogen Receptor (ER) and Progesterone (PR), this subtype demonstrates lower activity on FDG imaging. Somatostatin receptors (SSTR) offer a potentially improved radiotracer target for ER+ /PR+ We present first in vivo clinical study comparing 68 Ga-DOTATATE (DOTA) conventional imaging (bone scan diagnostic CT), metastatic human epidermal growth factor receptor 2 (HER2) negative...
Primary amine-functionalized glass slides obtained through a multi-step plasma treatment were conjugated with anionic amino acids that are frequently found as mineral binding elements in acidic extracellular matrix components of natural bone. The modified surfaces characterized by X-ray photoelectron spectroscopy (XPS) and contact angle measurements. Human osteosarcoma TE85 cells cultured on these functionalized analyses both protein gene expression levels performed to probe the...
5559 Background: There has been little change in the outcome of patients with PROC over last 20 years despite large numbers entered on clinical trials. We examined design and results Ph2t Ph3t to understand potential reasons for this an effort improve trial PROC. Methods: conducted a systematic review published between January 2000 March 2015. extracted data objective response rate (ORR) 6-month progression-free survival (PFS6) Ph3t. Inter-study heterogeneity was assessed using Q statistic....
The protein-DNA interactions of the upstream promoter region human embryonic zeta-globin gene in nuclear extracts erythroid K562 cells and nonerythroid HeLa were analyzed by DNase I footprinting, gel mobility shift assay, methylation interference, oligonucleotide competition experiments. There are mainly two clusters factor-binding sites zeta promoter. proximal cluster spans DNA sequence from -110 to -60 consists binding for CP2, Sp1, NF-E1. NF-E1 is specific, whereas CP2 common both types...