A5040940175- BRCA gene mutations in cancer
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Breast Lesions and Carcinomas
- PARP inhibition in cancer therapy
- Renal cell carcinoma treatment
- Cancer and Skin Lesions
- Acute Lymphoblastic Leukemia research
- Adolescent and Pediatric Healthcare
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Breast Implant and Reconstruction
- Cardiac tumors and thrombi
- Vascular Tumors and Angiosarcomas
- Sarcoma Diagnosis and Treatment
Hospital Universitario Virgen de la Arrixaca
2014-2024
Importance RAD51C and RAD51D are involved in DNA repair by homologous recombination. Germline pathogenic variants (PVs) these genes associated with an increased risk of ovarian breast cancer. Understanding the recombination deficiency (HRD) status tumors from patients germline PVs RAD51C/D could guide therapeutic decision-making improve survival. Objective To characterize clinical tumor characteristics PV carriers, including evaluation HRD status. Design, Setting, Participants This...
Glycogen-rich clear cell (GRCC) is a rare subtype of breast carcinoma characterized by cells containing an optically cytoplasm and intracytoplasmic glycogen. We present the case 55-year-old woman with palpable mass in right clinical signs locally advanced cancer (LABC). The diagnosis GRCC was based on certain histopathological characteristics tumor immunohistochemical analysis. To our knowledge, this first LABC intratumoral calcifications. There no evidence recurrence or metastatic disease...
Resumen Objetivos El síndrome de cáncer mama y ovario hereditario (SCMOH) presenta un patrón herencia autosómica dominante en genes susceptibilidad al su riesgo está principalmente vinculado a mutaciones germinales BRCA1 BRCA2 . Sin embargo, la implementación paneles genéticos mediante secuenciación masiva práctica asistencial, ha ampliado el espectro mutacional este número variantes significado clínico desconocido (VUS) detectadas los estudios genéticos. Métodos estudio prevalencia del...
Hereditary breast and ovarian cancer (HBOC) follows an autosomal dominant inheritance pattern of susceptibility genes. The risk developing this disease is primarily associated with germline mutations in the BRCA1 BRCA2 advent massive genetic sequencing technologies has expanded mutational spectrum hereditary syndrome, thereby increasing number variants uncertain clinical significance (VUS) detected by testing.A prevalence study HBOC was performed within 2,928 families from Region Murcia,...
5566 Background: Circulating free DNA (cfDNA) and circulating tumor cells (CTC) are new biomarkers for malignant tumors. Its role on ovarian epithelial cancer (OEC) is not yet well stablished. We analyze its advanced OEC compared with CA125 HE4. Methods: Multicentric prospective observational study from November 2013 until February 2017, patients group (OECG), benign tumors (BENIGNG) health subjects control (HEALTHG). CTCs were analysed by the CellSearch method cfDNA ALU-sequences-based...
<h3>Introduction/Background</h3> TP53 is a tumour suppressor gene frequently mutated in high grade serous ovarian cancer(HGSOC).The aim of this study to investigate the expression TP5-gene cell-free DNA(cfDNA) plasma and paraffin-embedded tissue HGSOC,both platinum-sensitive(PSR)and platinum-resistant relapse(PRR)patients. <h3>Methodology</h3> This multicentric prospective observational has been conducted from November/2013 February/2017 patients diagnosed HGSOC.Ampliseq custom panel was...
Purpose: The purpose of this study was to disclose the variability pathways currently taken in treatment adolescent patients from diagnosis final follow-up with a view developing more homogenous system. Patients & methods: A cross-sectional, observational and retrospective cancer assignment medical care teams (12-20 years) January 2008 December 2018 conducted. total 345 aged between 12 20 years, diagnosed treated at Hospital Clinico Universitario Virgen de la Arrixaca were included. Results:...