A5075147018- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Connective tissue disorders research
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Coronary Interventions and Diagnostics
- Infectious Aortic and Vascular Conditions
- Williams Syndrome Research
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Health and Medical Research Impacts
- Cardiac and Coronary Surgery Techniques
- Cardiovascular and Diving-Related Complications
- Health Systems, Economic Evaluations, Quality of Life
The University of Sydney
2016-2025
Royal Prince Alfred Hospital
2014-2024
Baird Institute
2015-2023
Robert Bosch (Australia)
2017-2020
Centenary Institute
2017
Renji Hospital
2017
University of Richmond
2015-2016
UNSW Sydney
2015
Macquarie University
2015
St Andrew’s Hospital
2012
Background— The natural history of aortic diseases in patients with TGFBR1 or TGFBR2 mutations reported by different investigators has varied greatly. In particular, the current recommendations for timing surgical repair root aneurysms may be overly aggressive. Methods and Results— Montalcino Aortic Consortium, which includes 15 centers worldwide that specialize heritable thoracic diseases, was used to gather data on 441 from 228 families, 176 cases harboring a mutation TGBR1 265 . Patients...
Reperfusion of ischemic myocardium may accelerate necrosis injured myocytes. To determine the role neutrophil leukocytes in this process, we examined whether depletion during reperfusion could modify infarct size anesthetized dogs. The proximal circumflex coronary artery was occluded for 90 minutes and then reperfused 2 hours via an extracorporeal circuit with either whole blood (n = 11) or depleted neutrophils by leukocyte filters 11). caused near-total neutropenia reperfusing (7 +/- 7...
Increased cardiac output in pregnancy is associated with remodeling and possible reduction contractility, which may worsen preeclampsia. Left ventricular (LV) geometry function were compared between nonpregnant controls ( n = 12) normotensive 44) preeclamptic 15) pregnant women using echocardiography. Load-independent comparisons of LV systolic end-systolic stress (ESS) rate-corrected velocity circumferential fiber shortening V CFC ). Mean arterial pressures 101 ± 14 mmHg preeclampsia, 76 6...
Background —The occurrence of myocyte necrosis during reperfusion ischemic myocardium is controversial. This study measured myocardial 2-deoxyglucose uptake, correlated with histology, to determine whether loss viability occurred myocardium. Methods and Results —In 12 anesthetized dogs, the left anterior descending coronary artery was occluded for 90 minutes before 4 hours reperfusion. Myocardial blood flow by microspheres tracers 14 C-2-deoxyglucose 18 F-2-deoxyglucose were injected...
Pathogenic variants in 11 genes predispose individuals to heritable thoracic aortic disease (HTAD), but limited data are available stratify the risk for events associated with these genes. This study sought compare of first event, specifically aneurysm surgery or an dissection, among 7 HTAD and variant types within each gene. A retrospective cohort probands relatives rare (n = 1,028) was assessed based on gene altered, pathogenic type, sex, proband status, location recruitment. Significant...
During reperfusion of a myocardial infarct, development microvascular occlusion may result in regional hypoperfusion ("no reflow") despite patent infarct-related artery. This study examined the extent and time course no reflow with use rubidium-82 positron emission tomography. In 12 anesthetized dogs, left anterior coronary artery was occluded for 90 min then freely reperfused. Regional perfusions imaged by serial rabidium-82 tomography during every 30 reperfusion. After 4 h reperfusion,...
This study examined the hypothesis that glycolysis is required for functional recovery of myocardium during reperfusion by facilitating restoration calcium homeostasis. [Ca2+]i was measured in isolated perfused rabbit hearts using Ca2+ indicator 1,2-bis(2-amino-5-fluorophenoxy)ethane-N,N,N',N'-tetraacetic acid (5F-BAPTA) and 19F nuclear magnetic resonance spectroscopy. In nonischemic control hearts, inhibition with iodoacetate did not alter [Ca2+]i. subjected to 20 minutes global zero-flow...
Abstract Background Medical degree programs use scholarly activities to support development of basic research skills, critical evaluation medical information and promotion research. The University Sydney Doctor Medicine Program includes a compulsory project. student projects are supervised by academic staff affiliates, including biomedical science researchers clinician-academics. This study investigated supervisors’ observations the barriers enablers successful projects. Methods Research...
Nitric oxide (NO) may protect arteries against atherosclerosis. In the present study, we examined whether dietary L-arginine, precursor of NO, could chronically preserve endothelium-dependent vasodilatation in vivo and/or limit atherogenesis.Rabbits were randomized according to sex receive 2% cholesterol, with or without L-arginine (2.25% solution), for 7 14 weeks. Hindlimb vasodilator responses acetylcholine and nitroprusside measured an electromagnetic flow probe. Atherosclerosis was...
Glycolysis normally provides only a small fraction of myocardial ATP production, but from glycolysis may be preferentially used to support membrane activities such as ion pumping. Since homeostasis is disturbed during ischemia, particularly important in the recovery post-ischemic myocardium. This hypothesis was investigated isovolumic, isolated rabbit hearts, perfused with 16 mM glucose, 5 pyruvate acetate. Global left ventricular function (rate-pressure product, RPP) and unidirectional...
Brief periods of myocardial ischemia prior to timely reperfusion result in prolonged, yet reversible, contractile dysfunction the myocardium, or "myocardial stunning". It has been hypothesized that delayed recovery function stunned myocardium reflects damage one a few key sarcomeric proteins. However, such proteins does not explain observed physiological alterations oxygen consumption and ATP requirements following stunning, therefore impact additional functional groups is unresolved. We...
Thoracic aortic aneurysm (TAA) is a potentially lethal condition, which can affect individuals of all ages. TAA may be complicated by the sudden onset life-threatening dissection or rupture. The underlying mechanisms leading to formation, particularly in nonsyndromal idiopathic group patients, are not well understood. Thus, identification new genes and targets that involved pathogenesis required help prevent reverse disease phenotype.Here we explore role ARHGAP18, novel Rho GAP expressed...
Background Experimental studies indicate that duration of ischemia is a major determinant myocardial infarct size, but only limited information available about the relation between time and size in individual patients. This prospective study sought to document role as humans. Methods Results We studied 61 patients (50 men, 11 women) 57±11 years old admitted with first (31 anterior, 30 inferior) who underwent continuous 12-lead ECG monitoring time. Infarct (32-point QRS score on day 7)...
Bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly, affecting 0.5-1.4% of general population (1-4). BAV a clinically heterogeneous disorder with high rate surgically relevant and ascending complications, which occur in over 35% those affected (5). As such, confers greater burden disease than all other heart diseases combined (3,6). Familial clustering genetic studies have established that heritable trait, approximately 9% prevalence amongst firstdegree relatives, up to...
Abnormal flow dynamics play an early and causative role in pathologic changes of the ascending aorta.To identify: 1) flow, shape, size that occur aorta with normal human ageing 2) influence these factors on aortic dynamics.Retrospective.In all, 247 subjects (age range 19-86 years, mean 49 ± 17.7, 169 males) free or valve pathology were included this study. Subjects stratified by youngest (18-33 years; n = 64), highest (>60 67), middle two quartiles (34-60 116).Subjects underwent a cardiac...