A5013250746- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Barrier Structure and Function Studies
- Liver Diseases and Immunity
- Phosphodiesterase function and regulation
- Diabetes Treatment and Management
- Colorectal Cancer Treatments and Studies
- Asthma and respiratory diseases
- Pharmacogenetics and Drug Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Infectious Diseases and Tuberculosis
- Ion Transport and Channel Regulation
- Polyomavirus and related diseases
- Renal Diseases and Glomerulopathies
- Allergic Rhinitis and Sensitization
- Gastric Cancer Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Peptidase Inhibition and Analysis
- Infectious Encephalopathies and Encephalitis
- Respiratory and Cough-Related Research
- Vasculitis and related conditions
Bispebjerg Hospital
2016-2020
Olgahospital
2015
Universitäts-HNO-Klinik Heidelberg
2004
Intracellular signaling through cyclic nucleotides, both AMP and GMP, is altered in colorectal cancer. Accordingly, it hypothesized that an underlying mechanism for neoplasia involves function of phosphodiesterases (PDEs), which affects nucleotide degradation. Here we present approach to evaluate the selected nucleotide-PDEs colonic endoscopic biopsies from non-neoplastic appearing mucosa. Biopsies were obtained patients with without neoplasia. Activities PDEs characterized functionally by...
Mucosal healing determined by endoscopy is currently the remission standard for ulcerative colitis (UC). However, new criteria are emerging, such as histologic normalization, which appears to correlate better risk of relapse. Here, we study mucosal on a molecular and functional level in quiescent UC. We obtained endoscopic biopsies from 33 UC patients 17 controls. Histology was assessed using Geboes score. Protein mRNA levels were evaluated tight junction proteins claudin-2, claudin-4,...
The pathogenesis of colorectal neoplasia (CRN) has been associated with altered non‐neuronal acetylcholine (ACh) metabolism. aim this study was to characterize expression, function, and cellular location ACh‐related proteins in biopsies obtained from endoscopic normal‐appearing sigmoid colon patients without CRN. Messenger‐RNA (mRNA) levels 17 were quantified by rt‐qPCR. Functional responses ACh, measured as electrogenic transepithelial short circuit current (SCC), recorded using the Ussing...
Einleitung: Die Granulomatose mit Polyangiitis (früher: M. Wegener) gehört zu den ANCA-assoziierten Vaskulitiden und führt einer nekrotisierenden Entzündung kleiner bis mittelgroßer Gefäße konsekutivem Endorganschaden an Nieren am Respirationstrakt. Zur Therapie stehen seit langem Steroide Cyclophosphamid zur Verfügung. Der CD-20-Antikörper Rituximab stellt einen neuen, vielversprechenden Therapieansatz dar.
Introduction: The descriptive diagnosis of MERS (first used in 2004) is largely based on MRI findings: a nonenhancing, round-shaped lesion the splenium corpus callosum with reduced diffusion that completely disappears within weeks. Until now, most patients have been reported Japan, associated viral infections (1/3 influenza viruses) causing encephalitis/encephalopathy.
The standard for assessing disease activity, clinical remission and response to therapy in ulcerative colitis (UC) includes evaluation of patient symptoms signs as well endoscopic mucosal status. ultimate goal is reversal inflammation its control, including a normalisation function (i.e., ion transport barrier integrity). Here, we hypothesise that relevant target-to-treat endpoint. In this exploratory study, studied the properties compared them endoscopy histology findings quiescent UC. We...
Thymus-Stroma-Lymphopoetin (TSL) aus Epithelzellen greift über die Aktivierung von dendritischen Zellen (CD11c+) in Th2-vermittelnde Immunantwort der allergischen Entzündungsreaktion ein. Ziel dieser Untersuchung war Expressionsmessung TSL und Interleukin 5 (IL-5) Nasenschleimhaut, um deren Bedeutung Interaktion für chronisch-hyperplastische Rhinosinusitis mit bilateralen Nasenpolypen (CHS/NP) zu evaluieren.