A5018338313- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrospinal fluid and hydrocephalus
- Spinal Hematomas and Complications
- Cerebral Venous Sinus Thrombosis
- Head and Neck Surgical Oncology
- Case Reports on Hematomas
- Fetal and Pediatric Neurological Disorders
- Pain Management and Placebo Effect
- Trauma and Emergency Care Studies
- Helicobacter pylori-related gastroenterology studies
- Anesthesia and Pain Management
- Neurological Complications and Syndromes
- Pain Mechanisms and Treatments
- Environmental and Sediment Control
- Takotsubo Cardiomyopathy and Associated Phenomena
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Animal testing and alternatives
- Advanced MRI Techniques and Applications
- Phosphodiesterase function and regulation
- Mindfulness and Compassion Interventions
- Diversity and Career in Medicine
- Problem Solving Skills Development
- Heart Rate Variability and Autonomic Control
Copenhagen University Hospital
2020-2025
Rigshospitalet
2019-2025
Odense University Hospital
2013-2021
Aarhus University Hospital
2021
Aarhus University
2021
Aalborg University Hospital
2021
University of Southern Denmark
2021
Bispebjerg Hospital
2016-2020
Placement of a subdural drain reduces recurrence and death after evacuation chronic hematoma (CSDH), but little is known about optimal drainage duration. In the present national trial, authors investigated effect duration on death.
Abstract Introduction The pathophysiology of chronic subdural hematoma (CSDH) remains to be fully understood. Basic knowledge the composition and features cells in CSDH fluid may contribute understanding seemingly complex processes involved formation recurrence. This study is first examine cellular both systemic blood from patients. We hypothesized that be; 1) different blood; 2) between patients with without recurrence; 3) second operation recurrent CSDH. Methods Systemic were collected at...
Abstract Background Burnout is a condition of mental, emotional, and physical enervation affecting personnel working in human services has been reported high among neurosurgical doctors. However, previous burnout reports are based on low response rates measured by the Maslach inventory, which for several reasons proven problematic. not previously investigated doctors Denmark. With this study we measure prevalence Denmark with sustainable methodology clinically relevant interpretation....
Background Colonic tuft cells are epithelial chemosensory involved in barrier integrity, modulation of inflammatory responses and gut homeostasis. Recent evidence indicates an involvement ulcerative colitis pathogenesis, though mechanisms remain largely unknown. Here, we quantified the colonic cell population patients with quiescent as compared to without identified disease (controls). Methods In this retrospective study, obtained endoscopic sigmoid biopsies from 14 17 controls. a blinded...
Rhino-orbital-cerebral mucormycosis (ROCM) is a rare fulminant opportunistic fungal infection that despite relevant treatment has high mortality. We present case of 3-year-old girl with acute lymphoblastic leukemia and ROCM, who was treated successfully excessive surgery, systemic antifungal amphotericin B (AmB), posaconazole, terbinafine as well hyperbaric oxygen. Surgery included, beside extracranial intracranial removal infected areas, endoscopic sinus skull base surgery local AmB...
Intracellular signaling through cyclic nucleotides, both AMP and GMP, is altered in colorectal cancer. Accordingly, it hypothesized that an underlying mechanism for neoplasia involves function of phosphodiesterases (PDEs), which affects nucleotide degradation. Here we present approach to evaluate the selected nucleotide-PDEs colonic endoscopic biopsies from non-neoplastic appearing mucosa. Biopsies were obtained patients with without neoplasia. Activities PDEs characterized functionally by...
Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 thought to be the predominant COX isozyme involved neoplasia. Meanwhile, relative contributions of COX-1 and isoforms are unknown. Knowledge about their mutual important for diagnostics targeted therapy CRN. The aim this study was assess function, expression localization enzymes non-neoplastic human thereby potentially reveal a mucosal disease predisposition...
Abstract Background Chronic subdural hematoma (CSDH) is a common acute or subacute neurosurgical condition, typically treated by burr-hole evacuation and drainage. Recurrent CSDH occurs in 5–20% of cases requires reoperation symptomatic patients, sometimes repeatedly. Postoperative drainage maximal 48 h effective reducing recurrent hematomas. However, the shortest possible time without increasing recurrence rate unknown. Methods DRAIN-TIME 2 Danish multi-center, randomized controlled trial...
Abstract In patients with hydrocephalus, prognosis and intervention are based on multiple factors. This includes, but is not limited to, time of onset, patient age, treatment history, obstruction cerebrospinal fluid flow. Consequently, several distinct hydrocephalus classification systems exist. The International Classification Diseases (ICD) universally applied, in ICD-10 the upcoming ICD-11, diagnoses incorporate only a few factors, ICD different clinical measures. As consequence, can be...
Abstract Chronic subdural hematoma (CSDH) development involves inflammatory, angiogenetic, and fibrinolytic mechanisms, several components of which are now unraveled through intensive research. The urokinase plasminogen activator receptor (uPAR) is part the system possesses capabilities. As a first, this study aims to identify uPAR in fluid, membrane, dura mater, systemic blood from patients with CSDH and, if present, investigate level at time surgery may be predictor for later developing...
Background: The discovery of biomarkers in chronic subdural haematomas (CSDH) suggests that inflammation is part CSDH pathophysiology. It unknown whether reflects an independent driver or haematoma degeneration. This knowledge holds a potential target for anti-inflammatory treatment patients at risk CSDH. study investigated the association pro- and factors with development. Methods: cohort included all individuals Denmark over 50 years between 2007– 2018. outcome was first-time surgery....
Subdural drainage reduces recurrence after evacuation of chronic subdural hematoma (CSDH). In the present study, authors investigated dynamics drain production and potentially contributing factors for recurrence.Patients treated with a single burr hole CSDH between April 2019 July 2020 were included. Patients also participants in randomized controlled trial. All patients included, had passive exactly 24 hours. Drain production, Glasgow Coma Scale score, degree mobilization was recorded every...
The pathogenesis of colorectal neoplasia (CRN) has been associated with altered non‐neuronal acetylcholine (ACh) metabolism. aim this study was to characterize expression, function, and cellular location ACh‐related proteins in biopsies obtained from endoscopic normal‐appearing sigmoid colon patients without CRN. Messenger‐RNA (mRNA) levels 17 were quantified by rt‐qPCR. Functional responses ACh, measured as electrogenic transepithelial short circuit current (SCC), recorded using the Ussing...
A further rise in chronic subdural haematoma (CSDH) prevalence is expected with an ageing population, and evidence-based guidelines are needed to direct treatment, while creating a platform for research. The Danish Chronic Subdural Hematoma Study (DACSUHS) has implemented the first national CSDH 2018 have standardised management on level. Based literature published between 2016 2022, these were updated 2022. presented this review.