Diabetes mellitus (DM), also known as diabetes, involves a group of metabolic disorders in which blood sugar levels are high over prolonged period. The present study was designed to evaluate the effect 21 days administration 100 and 200 mg per kg bodyweight ethanolic extract Chrysophyllum albidum (African star apple) fruit-skin on streptozotocin (STZ)-diabetic Wistar albino rats. A randomized control trial used. Diabetic state test rats induced with at dose 60 streptozotocin/kg body using...

This study was conducted in order to elucidate the effects of cyanide (CN−) as sodium on oxidative parameters tissues birds (Gallus domesticus L.) exposed CN− directly by gavage and indirectly through their feed. Lipid peroxidation (LPO) level activities catalase (CAT) superoxide dismutase (SOD) were determined kidney, liver, heart, brain birds. LPO significantly (p < 0.05) increased a dose-dependent manner all (feed), while CAT SOD concomitantly decreased regardless mode exposure. However,...

At present there is no approved food antidote for cyanide poisoning. Therefore, plants are being tested as possible antidotes (CN) toxicity. This study aimed to evaluate the protective role of ethanolic extract Tetrapleura tetraptera (T. tetraptera) against nephrotoxicity and hepatotoxicity in male rats. Forty five albino rats divided into nine groups were used experiment: Group 1 received water only, 2 CN 3 + thiosulphate, Groups 4, 5 6 100, 250 500 mg/kg T extract, respectively. 7, 8 9...

Background. Several toxicants present simultaneously in the environment have combined toxicological effects. In addition, various xenobiotics distinct effects on oxidative stress biomarkers animal cells and tissues.&#x0D; The aim of this study was to analyze effect cadmium (Cd) cyanide (CN) through food chain some antioxidant indices tissues (lungs, testes, heart, brain) male Wistar rats.&#x0D; Materials Methods. included sixty African catfish allocated four groups, each comprising fifteen...

Background: The present study was performed to explore whether the aqueous extract of Senecio biafrae (S. biafrae) roots provide any in vivo protective activity against carbon tetrachloride (CCl4)-induced hepatotoxicity male albino rats. Methods: Rats (150-200 grams) were grouped into five groups (A-E) six rats each and treated orally for twelve days with 72 hourly administration CCl4 (1 mL/kg) as follows: Group A received distilled water only (negative control), B administered plus...

The phytochemical screening, antioxidant, and nephroprotective effects of methanol acetone extracts cassava (Manihot esculenta Crantz) leaves were comparatively investigated using standard procedures. Fifty-four male Wistar rats (albino) divided into nine groups six each. Group 1 = negative control (normal untreated + normal saline); group 2 positive (rats 2g/kg bw acetaminophen saline), 3, 4, 5 200 mg/kg bw, 100 50 extract, respectively, acetaminophen; 6, 7, 8 mg/kg, 9 silymarin...

Recently, phytomedicine have been applied in the management of various diseases related to toxicity. In addition, attention has on cyanide toxicity due its harmful effects man and animals. Thus, this research was carried out determine effect Acalypha wilkesiana methanol leaf extract induced renal damage rats. 45 female Wister rats randomly divided into 7 groups were used for study. Group 1:received neither nor fraction (MFAW), 2 3 received different doses MFAW respectively, 4 only, 5 Rats...

Diverse organismsuch as mammals and fishes exposure to noxious waste in the surroundings is a continuous routine active absorption propagation of contaminants humans through food chain. In order determine level toxicity across chain,this research was structured identify some biochemical alterations hepatic tissue rats fed cadmium, cyanide mixture cadmium contaminated catfish diet. Fish were assigned into four groups exposed both toxicants (cadmium cyanide) single combined states. Each...

Introduction: Carbon tetrachloride (CCl4) has been used extensively to evaluate the probable mechanisms of toxicity in experimental animals. The CCl4 induced oxidative stress rat brain established. This study aim investigate neuro-prot.

The research affirmed that Cola nitida L. and Garcinia kola Heckel used in Nigeria are quite different medicinally nutritionally. proportions of all nutrients analyzed quantitatively (lipid, moisture, fibre, ash, protein except carbohydrate) were greater C. than G. (p&lt;0.05). has a lower energy density (332.20 kcal/g vs 349.10 sample) Alkaloids, flavonoids, phenolics, cardiac glycosides significantly at p&lt;0.05, addition to saponin, tannin, steroids. A 72-hour methanol extraction nuts by...

Despite the fact that cyanide is known to be toxic, it found in popular foods consumed by humans and animals, there therefore need find an appropriate food can help ameliorate its effect both man animals. The study aims determine of different concentrations bitter leaf extract (BLE) on hematological parameters blood lipid profile rats exposed cyanide. A total twenty four were used for this they divided into six groups, each containing rats. All groups fed with growers mash addition Group 1...

The sub-acute effect of F. capensis was assessed on the oxidative stress markers in kidney rats following exposure to cyanide. These effects were compared those sodium thiosulphate (Na2S2O3), a classical antidote cyanide toxicity. divided into 9 groups 5 animals each. Group 1: (normal control); 2: exposed 3mg/kg cyanide; group 3: induced that received 660mg/kg pentahydrate and 6.6 mg/kg nitrite; 4 5: cyanide, pre-treated with 200 400mg/kg extract respectively; 6 7: post-treated 400 8 9:...

This study was based on the antitodal effect of aqueous garlic (Allium sativum) and ginger extract (Zingiber officinale) in broiler birds given different concentrations cyanide by gavage for 6 weeks. A total twenty four were used study. The divided into 4 groups labeled Group (normal control), B (cyanide C garlic) D Ginger) respectively. Each group contains six each. bird weighed administered according to their body weight every morning. levels serum aspartate aminotransferase (AST), alanine...

Abstract This study determined the effect of lead-cadmium toxicity in liver albino rats. 56 rats were divided into 7 groups 8 each and treated as follows : Group A Control (1 ml diluent (corn oil); B (15mg/kg BW cadmium); C(50mg/kg lead); D Cadmium 50mg/kg E cadmium, lead 23mg/kg vitamin E);Group F 25mg/kg Butylated HydroxylToluene) G (15 mg/kg Cd+50mg/kg lead+25mg/kg (BHT + E). Rats sacrificed on 29th 56th day sub-acute chronic exposure respectively. Liver function, oxidative stress markers...

The purpose of this study was to determine combined effect Xylopia aethiopica seed (Xa) and Monodora myristica extracts (Mm) on haematological parameters{pack cell volume (PCV), haemoglobin (Hb) , red blood count (RBC) white (WBC) } lipid profile {Total cholesterol (TC), triglycerides (TG), highdensity lipoproteins (HDL) low-density (LDL) }in cyanide exposed rats. conducted using 32 male rats weighing between 120 150 g. were divided into 8 groups 4 in each group as follows; Group 1:...