A5048819265- Neonatal Respiratory Health Research
- Endometriosis Research and Treatment
- Digital Mental Health Interventions
- Mobile Health and mHealth Applications
- Infant Development and Preterm Care
- Rheumatoid Arthritis Research and Therapies
- Mental Health Research Topics
- Neonatal and Maternal Infections
- Infant Nutrition and Health
- Social Media in Health Education
- Asthma and respiratory diseases
- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders Research
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Transplantation: Methods and Outcomes
- Cystic Fibrosis Research Advances
- Childhood Cancer Survivors' Quality of Life
- Pregnancy and preeclampsia studies
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Patient-Provider Communication in Healthcare
- Spondyloarthritis Studies and Treatments
- Adenosine and Purinergic Signaling
AbbVie (United States)
2018-2025
Northwestern University
2015-2020
Lurie Children's Hospital
2015-2020
Yale University
2019
Behavioral Tech
2015-2018
RELX Group (United States)
2018
University of Wisconsin–Madison
2015
Background: Digital mental health tools have tended to use psychoeducational strategies based on treatment orientations developed and validated outside of digital health. These features do not map well the brief but frequent ways that people mobile phones phone apps today. To address these challenges, we a suite for depression anxiety called IntelliCare, each with focused goal interactional style. IntelliCare prioritize interactive skills training over education are designed short interactions.
To evaluate the long-term safety profile for upadacitinib across rheumatoid arthritis (RA), psoriatic (PsA), ankylosing spondylitis (AS) and atopic dermatitis (AD).Safety data from clinical trials of 15 mg 30 (AD only) treating RA, PsA, AS AD as June 2021 were analysed; some RA PsA studies included adalimumab methotrexate active comparators. Treatment-emergent adverse events (TEAEs) presented by disease exposure-adjusted event rates per 100 patient years (E/100 PY).The analysis 6991 patients...
Increased risk of serious adverse events (AEs) was reported for tofacitinib relative to tumour necrosis factor inhibitor therapy in patients with rheumatoid arthritis (RA) aged ≥50 years enriched cardiovascular (CV) (ORAL Surveillance). We assessed post hoc the potential upadacitinib a similar RA population.Pooled safety data from six phase III trials were evaluated AEs receiving 15 mg once day (with or without conventional synthetic disease-modifying antirheumatic drugs), adalimumab 40...
Upadacitinib is indicated for diseases affecting persons of childbearing potential including rheumatoid arthritis, psoriatic axial spondyloarthritis, atopic dermatitis, Crohn's disease, and ulcerative colitis; however, teratogenicity was observed in animal studies. Given the human fetal risk, pregnancy avoidance measures were required during clinical trials. This analysis describes outcomes patients exposed to upadacitinib pregnancy. Clinical trial postmarketing cases utero exposure...
Background Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation acute phase reactant (APR) biomarkers umbilical cord blood at birth may improve EOS detection infants intrauterine infection. Methods In this nested case-control study, (29.7 weeks gestation, IQR: 27.7–32.2) were identified from longitudinal cohort archived placental...
Abstract Objective SCN2A ‐associated developmental and epileptic encephalopathies (DEEs) present with seizures, impairments, often both. We sought to characterize the level pattern of development in children variants, address sensitivity Vineland Adaptive Behavior Scales (VABS) measuring changes over time ‐DEEs. Methods Clinical histories for participants pathogenic variants Simons SearchLight project were analyzed descriptive purposes. VABS scores obtained at study entry yearly thereafter...
Objectives To provide an integrated analysis of major adverse cardiovascular events (MACEs) and venous thromboembolism (VTE) associated risk factors across rheumatoid arthritis (RA), psoriatic (PsA), ankylosing spondylitis (AS) phase 2b/3 upadacitinib clinical programmes. Methods Data were analysed summarised from trials RA, PsA AS treated with 15 mg once daily (QD) 30 QD (as June 2021). adalimumab (RA PsA) methotrexate (RA) arms included as comparators. Adjudicated MACEs VTE presented...
Major depressive disorder is a common psychological problem affecting up to 20% of adults in their lifetime. The majority people treated for depression receive antidepressant medication through primary care physician. This commonly results low rates recovery. Failure points the process contributing poor outcomes include patient non-adherence medications, failure physicians optimize dose and absence communication between patients physicians.This pilot study evaluated feasibility systemic...
This article aims to describe malignancies in patients with rheumatoid arthritis (RA), psoriatic (PsA), ankylosing spondylitis (AS), or non-radiographic axial spondyloarthritis (nr-axSpA) treated upadacitinib (UPA) active comparators. integrated safety analysis includes data from 11 phase 3 UPA trials across RA (6 trials), PsA (2 AS trials; one 2b/3), and nr-axSpA (1 trial). Treatment-emergent adverse events (TEAEs) were summarized for (pooled 15 mg [UPA15], pooled 30 [UPA30], adalimumab 40...
The development of pulmonary hypertension (PH) is a serious complication bronchopulmonary dysplasia (BPD) among infants born at extremely low gestational ages. Bronchopulmonary dysplasia-associated PH characterized by persistent vasoconstriction, progressive right heart dysfunction, and an increased risk death. We have shown previously that certain placental vascular lesions are associated with BPD-associated PH. Further evaluation the villous morphometry these placentas warranted. Using...
Background: The ability to successfully recruit participants for electronic health (eHealth) clinical trials is largely dependent on the use of efficient and effective recruitment strategies. Determining which types strategies presents a challenge many researchers. Objective: aim this study was present an analysis time-efficiency cost-effectiveness eHealth trials, it describes framework cost-effective trial recruitment. Methods: Participants were recruited one 5 interventions common mental...
Major depression is common, and imposes a high burden in terms of cost, morbidity, suffering. Most people with are treated general medicine using antidepressant medication. Outcomes poor due to failure points across the care system, including patient non-adherence, physicians optimize treatment regimens, lack patient-physician communication. This study reports on 4-week pilot deployment MedLink, mobile intervention aimed at systemically addressing each these points. A app provides...
Kawasaki disease (KD) shock syndrome (KDSS) is hypotension with KD. We compared children KDSS and matched control Children more often were female, had a lower platelet count sodium concentration, condition refractory to immunoglobulin, abnormal echocardiography results. unique subset of
Past studies have not evaluated inhaler use in hospitalized children with asthma. The objectives of this study were to evaluate technique pediatric patients asthma and identify risk factors for improper use. We conducted a prospective cross-sectional tertiary children's hospital 2-16 years age admitted an exacerbation, demonstrations analyzed. Of 113 participants enrolled, 55% had uncontrolled asthma, 42% missed critical step technique. More when they used spacer mouthpiece instead mask (75%...
The content of pediatric hospital discharge instructions is highly variable. This study aimed to describe the characteristics, accessibility per patient literacy level and language, national guideline adherence instructions.This retrospective assessed at a tertiary children's hospital. Patient instruction including health level, grade instructions, language preference, were collected via chart review electronic medical record query. Standard admission processes Brief Health Literacy...