A5024194722- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Vehicle emissions and performance
- Energy and Environment Impacts
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- COVID-19 impact on air quality
- Atmospheric chemistry and aerosols
- IL-33, ST2, and ILC Pathways
- Indoor Air Quality and Microbial Exposure
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Carcinogens and Genotoxicity Assessment
- COVID-19 epidemiological studies
- Asthma and respiratory diseases
- Blood Coagulation and Thrombosis Mechanisms
- Global Health Care Issues
- Occupational exposure and asthma
- Heme Oxygenase-1 and Carbon Monoxide
- Traffic and Road Safety
- Renin-Angiotensin System Studies
- Nuclear Receptors and Signaling
- Complement system in diseases
- Venous Thromboembolism Diagnosis and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Circadian rhythm and melatonin
National Institute for Public Health and the Environment
2014-2025
Mount Sinai Hospital
2011
Umeå University
2011
University of Edinburgh
2009-2011
Mount Sinai Hospital
2011
Finnish Institute for Health and Welfare
2009
Finnish Meteorological Institute
2009
Radboud University Nijmegen
2001
The oxidative potential (OP) of particulate matter (PM) has been proposed as a more health relevant metric than PM mass. Different assays exist for measuring OP and little is known about how the different compare. To assess collected at site types to evaluate differences between locations, size fractions correlation with mass composition measurement methods OP. PM2.5 PM10 was sampled 5 sites: an underground station, farm, 2 traffic sites urban background site. Three a-cellular assays;...
In controlled human exposure studies, diesel engine exhaust inhalation impairs vascular function and enhances thrombus formation. The aim of the present study was to establish whether an particle trap could prevent these adverse cardiovascular effects in men.Nineteen healthy volunteers (mean age, 25±3 years) were exposed filtered air presence or absence a for 1 hour randomized, double-blind, 3-way crossover trial. Bilateral forearm blood flow plasma fibrinolytic factors assessed with venous...
The etiology and progression of neurodegenerative disorders depends on the interactions between a variety factors including: aging, environmental exposures, genetic susceptibility factors. Enhancement proinflammatory events appears to be common link in different neurological impairments, including Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, multiple sclerosis. Studies have shown exposure particulate matter (PM), present air pollution, enhancement central nervous system...
Underground railway stations are known to have elevated particulate matter (PM) loads compared ambient air. As these particles derived from metal-rich sources and transition metals may pose a risk health by virtue of their ability catalyze generation reactive oxygen species (ROS), potential enrichment in underground environments is source concern. Compared coarse (PM10) fine (PM2.5) fractions airborne PM, little about the chemistry ultrafine (PM0.1) fraction that contribute significantly...
Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor particulate pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects female 5X Familial AD (5XFAD) mice their wild-type littermates. Following 3 13 weeks exposures diluted DEE (0.95 mg/m3, 6...
BackgroundAir pollution has consistently been associated with increased morbidity and mortality due to respiratory cardiovascular disease. Underlying biological mechanisms are not entirely clear, hemostasis inflammation suggested be involved.ObjectivesOur aim was study the association of variation in local concentrations airborne particulate matter (PM) aerodynamic diameter < 10 μm, carbon monoxide, nitrogen dioxide, ozone platelet aggregation, thrombin generation, fibrinogen, C-reactive...
Residence in urban areas with much traffic has been associated various negative health effects. However, the contribution of emissions to these adverse effects not fully determined. Therefore, objective this vivo study is compare pulmonary and systemic responses rats exposed particulate matter (PM) obtained from locations contrasting profiles. Samples coarse (2.5 μm–10 μm) fine (0.1 μm–2.5 PM were simultaneously collected at nine sites across Europe a high-volume cascade impactor. Six...
The authors have previously demonstrated heterogeneities in the inflammatory activities of urban air fine (PM2.5–0.2) and coarse (PM10–2.5) particulate samples collected from six European cities with contrasting pollution situations. same (10 mg/kg) were intratracheally instilled to healthy C57BL/6J mice either once or repeatedly on days 1, 3, 6 study week. lungs lavaged 24 h after single dose last repeated dosing. In both size ranges, dosing particles increased total cell number...
Objective: There is substantial evidence that exposure to airborne particulate matter (PM) from road traffic associated with adverse health outcomes. Although it often assumed be caused by vehicle exhaust emissions such as soot, other components may also contribute detrimental effects. The toxicity of fine PM (PM2.5; <2.5 µm mass median aerodynamic diameter) released brake pads was compared sources.Materials and methods: PM2.5 different types (low-metallic, semi-metallic, NAO ECE-NAO...
Several studies have linked air pollution to COVID-19 morbidity and severity. However, these do not account for exposure levels SARS-CoV-2, nor different sources of pollution. We analyzed individual-level data 8.3 million adults in the Netherlands assess associations between long-term ambient SARS-CoV-2 infection (i.e., positive test) hospitalisation risks, accounting spatiotemporal variation during first two major epidemic waves (February 2020–February 2021). estimated average annual...
Exposure to ambient particulate matter (PM) is statistically significantly associated with morbidity and mortality. The objectives of this study were (a) investigate in vivo pulmonary systemic cytotoxicity inflammatory activity compromised animals exposed PM (b) the relationships outcomes chemical compositions particular polycyclic aromatic hydrocarbons (PAH) transition metals PM. samples collected European cities representing contrasting situations. spontaneously hypertensive rats (7 mg...
Combustion-derived nanoparticles, such as diesel engine exhaust particles, have been implicated in the adverse health effects of particulate air pollution. Recent studies suggest that inhaled nanoparticles may also reach and/or affect brain. The aim our study was to comparatively evaluate short-term (DEE) inhalation exposure on rat brain and lung. After 4 or 18 h recovery from a 2 nose-only DEE (1.9 mg/m(3)), mRNA expressions heme oxygenase-1 (HO-1), inducible nitric oxide synthase (iNOS),...
Epidemiological studies show heterogeneities in the particulate pollution-related exposure–effect relationships among cardiorespiratory patients, but connection to chemical composition and toxic properties of inhaled particles is largely unknown. To identify constituents sources responsible for diverse inflammatory cytotoxic effects urban air, fine (PM2.5–0.2) coarse (PM10–2.5) samples were collected during contrasting air pollution situations. We exposed mouse RAW 246.7 macrophages 24 hrs...
The link between emissions of vehicular particulate matter (PM) and adverse health effects is well established. However, the influence new emission control technologies fuel types on both PM has been less investigated. We examined impact from two vehicles equipped with or without a diesel filter (DPF). Both were powered either (B0) 50% v/v biodiesel blend (B50). DPF effectively decreased mass (∼85%), whereas B50 lead to reduction (∼50%). hazard per unit distance driven was for DPF-equipped...
Relatively high concentrations of ultrafine particles (UFPs) have been observed around airports, in which aviation and road traffic emissions are the major sources. This raises concerns about potential health impacts airport UFPs, particularly comparison to those emitted by traffic. UFPs mainly derived from or were collected a location near international airport, Amsterdam-Schiphol (AMS), depending on wind direction, along with an aircraft turbine engine at low full thrust. Human bronchial...
Abstract Background Airborne fine particulate matter with diameter < 2.5 μm (PM2.5), can reach the alveolar regions of lungs, and is associated over 4 million premature deaths per year worldwide. However, source-specific consequences PM2.5 exposure remain poorly understood. A major, but unregulated source car brake wear, which exhaust emission reduction measures have not diminished. Methods We used an interdisciplinary approach to investigate brake-wear upon lung cellular homeostasis...
Proximity to traffic-related pollution has been associated with poor respiratory health in adults and children.We wished test the hypothesis that particulate matter (PM) from high-traffic sites would display an enhanced capacity elicit inflammation.We examined inflammatory potential of coarse [2.5-10 µm aerodynamic diameter (PM(2.5-10))] fine [0.1-2.5 (PM(0.1-2.5))] PM collected nine throughout Europe contrasting traffic contributions. We incubated murine monocytic-macrophagic RAW264.7 cells...
Abstract Background This study was performed within the scope of two multi-center European Commission-funded projects (HEPMEAP and PAMCHAR) concerning source-composition-toxicity relationship for particulate matter (PM) sampled in Europe. The present aimed to optimize design PM vivo toxicity screening studies terms dose time between a single exposure determination biological responses rat model mimicking human disease resulting susceptibility ambient PM. Dust thoracic size-range (aerodynamic...