A5060189475- Corporate Finance and Governance
- Law, Economics, and Judicial Systems
- Auditing, Earnings Management, Governance
- Private Equity and Venture Capital
- Financial Markets and Investment Strategies
- Corporate Governance and Law
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Neuroinflammation and Neurodegeneration Mechanisms
- Insurance and Financial Risk Management
- Legal Studies and Reforms
- International Arbitration and Investment Law
- Corporate Insolvency and Governance
- Autopsy Techniques and Outcomes
- Political Influence and Corporate Strategies
- Extracellular vesicles in disease
- Corporate Law and Human Rights
- Retinal Development and Disorders
- Financial Reporting and Valuation Research
- Receptor Mechanisms and Signaling
- Auction Theory and Applications
- Complement system in diseases
- Data-Driven Disease Surveillance
- European and International Contract Law
- Animal Disease Management and Epidemiology
Washington University in St. Louis
2008-2024
Institute of Neuroimmunology of the Slovak Academy of Sciences
2023
Hamilton County Coroner
2021-2023
Keele University
2023
University of California, Berkeley
2015-2023
Indiana University
2023
Johns Hopkins University
2023
Indiana University School of Medicine
2023
University of Georgia
2023
Berkeley College
2021
Abstract This study analyzes the relation between chief executive officer (CEO) personal risk-taking, corporate and total firm risk. We find evidence that CEOs who possess private pilot licenses (our proxy for risk-taking) are associated with riskier firms. Firms led by have higher equity return volatility, beyond amount explained compensation components financially reward risk-taking. trace source of elevated risk to specific policies, including leverage acquisition activity. Our results...
Abstract Background The blood–brain and blood–tumor barriers (BBB BTB), which restrict the entry of most drugs into brain tumor, respectively, are a significant challenge in treatment glioblastoma. Laser interstitial thermal therapy (LITT) is minimally invasive surgical technique increasingly used clinically for tumor cell ablation. Recent evidence suggests that LITT might locally disrupt BBB integrity, creating potential therapeutic window opportunity to deliver otherwise brain-impermeant...
VEEV, WEEV, and eastern equine encephalitis virus (EEEV) are emerging infectious diseases in the Americas, they have caused several major outbreaks human horse population during past few decades. Shortly after infection, these viruses can infect CNS, resulting severe long-term neurological deficits or death. Neuroinvasion has been associated with entry into CNS directly from bloodstream; however, underlying molecular mechanisms remained largely unknown. Here, we demonstrate that following...
Abstract Background Venezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in nasal cavity after intranasal exposure. While it is known VEEV has evolved several mechanisms to inhibit type I interferon (IFN) signaling infected cells, whether this inhibits virologic control during neuroinvasion along OSN not been studied. Methods We utilized an established murine model of infection with and a repository...
We analyze a direct product of the investment banking process: target firm valuations disclosed in fairness opinions negotiated mergers. On average, acquirer advisers exhibit positive valuation errors that are significantly greater than those advisers. Top-tier produce more accurate lower tier advisers, but we find no relation between accuracy and contingency structure advisory fees. The stock price reactions to merger announcements public disclosure target-sought positively related...
Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels HRPII are associated with cerebral malaria, a severe and highly fatal complication malaria. has been shown to induce vascular leakage, hallmark in blood–brain barrier (BBB) animal models. We have discovered an important mechanism for BBB disruption that driven unique features HRPII. By characterizing serum from infected patients produced P. parasites culture,...
This study analyzes the relation between CEO personal risk-taking, managerial risk-taking and total firm risk. We find evidence that CEOs who possess private pilot's licenses, our proxy for are associated with riskier firms. Firms led by pilots have higher equity return volatility, even beyond amount explained a wealth effect related to compensation structure. trace source of elevated risk specific corporate policies including leverage acquisition activity. Our results suggest non-pecuniary...
This study evaluates the relation between hostile takeovers and 17 takeover laws from 1965 to 2014. Using a hand-collected dataset of largely exogenous legal changes we find that certain laws, such as poison pill business combination have no discernible impact on activity, while others fair price reduced takeovers. We construct Takeover Index higher protection is associated with lower firm value, consistent entrenchment agency costs. However, conditional bid, firms more achieve premiums,...
Summary Innate immune cells are integral to the pathogenesis of several diseases central nervous system (CNS), including multiple sclerosis (MS). Dendritic (DCs) potent CD11c + antigen‐presenting that critical regulators adaptive responses, particularly in autoimmune such as MS. The regulation DC function both periphery and CNS compartment has not been fully elucidated. One limitation studying role DCs is microglia can upregulate during inflammation, making it challenging distinguish bone...
Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) a recently reported entry VEEV. Here, using wild-type and Ldlrad3-deficient mice, we define critical role LDLRAD3 in controlling steps VEEV infection, pathogenesis, neurotropism. Our analysis shows that required efficient infection pathogenesis prior to after central nervous...
We study retail shareholder voting using a nearly comprehensive sample of U.S. ownership and records. Analyzing turnout within rational choice framework, we find that participation increases with expected benefits from winning decreases higher costs participation. Even shareholders negligible likelihood affecting the outcome have non-zero turnout, consistent consumption voting. Conditional on participation, punish management poorly performing firms. Overall, our evidence provides support for...
Despite its dominance of the market for public company corporate charters, Delaware has come under increasing fire losing ground to other states in competition retain litigation. To test this criticism, we evaluate selection governing law and forum clauses 1,020 merger agreements between firms from 2004–2008. This sample provides a clean real‐time attractiveness states' judiciary during period. In contrast prior research, find that Delaware's merging parties increased recent years. Parties...