Lei Liu

ORCID: 0000-0003-1331-9363
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About
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Research Areas
  • Cerebrovascular and Carotid Artery Diseases
  • Intracranial Aneurysms: Treatment and Complications
  • Migraine and Headache Studies
  • Acute Ischemic Stroke Management
  • Moyamoya disease diagnosis and treatment
  • Cardiac Health and Mental Health
  • Salivary Gland Disorders and Functions
  • Ferroptosis and cancer prognosis
  • Multiple Sclerosis Research Studies
  • Dental Anxiety and Anesthesia Techniques
  • Trigeminal Neuralgia and Treatments
  • Vascular Malformations Diagnosis and Treatment
  • Oropharyngeal Anatomy and Pathologies
  • Pediatric Pain Management Techniques
  • Peroxisome Proliferator-Activated Receptors
  • Mitochondrial Function and Pathology
  • Parkinson's Disease Mechanisms and Treatments
  • COVID-19 Clinical Research Studies
  • Cardiac Valve Diseases and Treatments
  • Aortic Disease and Treatment Approaches
  • Neonatal and fetal brain pathology
  • Neurological Complications and Syndromes
  • Spinal Hematomas and Complications
  • Retinoids in leukemia and cellular processes
  • Genetic Neurodegenerative Diseases

Wuhan Third Hospital
2025

Tongren Hospital
2025

China-Japan Friendship Hospital
2013-2024

Sichuan University
2022

West China Second University Hospital of Sichuan University
2022

Great Ormond Street Hospital
2020

University College London
2020

China International Science and Technology Cooperation
2020

Children's Hospital of Chongqing Medical University
2020

Chongqing Medical University
2020

Anxiety and depression are the most common psychiatric comorbidities in migraine, but their impact on risk of developing migraine gender age differences unclear, research associations with migraine-related burdens limited.To systematically explore association between anxiety burdens, including as well frequency, severity, disability, headache impact, quality life sleep quality.A total 170 migraineurs 85 sex-and age-matched healthy control subjects were recruited consecutively for this study....

10.3389/fneur.2023.1090878 article EN cc-by Frontiers in Neurology 2023-04-25

Cerebral ischemia is the most common cerebrovascular disease worldwide. Recent studies have demonstrated that curcumin had beneficial effect to attenuate cerebral ischemic injury. However, it unclear how protects against In present study, using rat middle artery occlusion model, we found was a potent PPAR γ agonist in upregulated expression and -PPRE binding activity. Administration of markedly decreased infarct volume, improved neurological deficits, reduced neuronal damage rats. addition,...

10.1155/2013/470975 article EN Evidence-based Complementary and Alternative Medicine 2013-01-01

To explore the preventive effect of FOCUS-PDCA management model on deep vein thrombosis (DVT) in elderly orthopedic patients after surgery. A total 229 who underwent surgery our hospital between January 2021 and December 2023 were divided into two groups: control group (n=104) intervention (n=125), based their admission order. The received routine intervention, while was treated with model. Coagulation function, DVT risk symptoms, incidence DVT, quality, patient satisfaction compared groups....

10.22540/jmni-25-061 article EN cc-by-nc-sa Journal of Musculoskeletal and Neuronal Interactions 2025-03-01

Abstract The mechanisms underlying ischemic infarction in patients with vertebrobasilar dolichoectasia (VBD) remain unclear. In this study, we retrospectively analyzed the imaging characteristics of high‐resolution magnetic resonance (HR‐MRI) VBD to explore possible stroke (IS) VBD. Patients were recruited from HR‐MRI database between July 2017 and June 2021. was used evaluate diameter, bifurcation height, laterality, arterial dissection, atherosclerotic plaques basilar artery (BA)....

10.1111/bpa.13135 article EN cc-by-nc Brain Pathology 2023-01-31

It is usually difficult to identify stroke pathogenesis for single lenticulostriate infarction with nonstenotic middle cerebral artery (MCA). Our aim differentiate the two pathogeneses, non-branch atheromatous small vessel disease and branch (BAD) by high-resolution magnetic resonance imaging (HR-MRI). Thirty-two patients MCA admitted China-Japan Friendship Hospital from December 2014 August 2017 were enrolled retrospective analysis. National Institutes of Health Stroke Scale (NIHSS),...

10.1186/s12883-018-1054-z article EN cc-by BMC Neurology 2018-04-25

Background Migraine has an increased prevalence in several immune disorders, but genetic cause-effect relationships remain unclear. Mendelian randomization (MR) was used this study to explore whether diseases are causally associated with migraine and its subtypes. Methods We conducted a two-sample bidirectional multivariate study. Single-nucleotide polymorphisms (SNP) for six diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), type 1 diabetes mellitus (T1D),...

10.3389/fimmu.2024.1376698 article EN cc-by Frontiers in Immunology 2024-04-08

The association between fenestrations and neurovascular pathology is not well defined. morphology of vessel wall plays an important role in the development pathology. We sought to explore plaque distribution around basilar artery fenestration (BAF) by three-dimensional high-resolution MR imaging (3D HRMRI). Patients with BAF on 3D HRMRI images were enrolled. All cross-sectional slices arteries assessed categorized based location as proximal segment, in-bifurcation distal segment....

10.1177/0963689719843813 article EN cc-by-nc Cell Transplantation 2019-04-15

Myotonic dystrophy (DM) is a chronic, slowly progressing, highly variable, inherited multisystemic disease, which includes two main types: DM type 1 (DM1) and 2 (DM2). Both DM1 DM2 are autosomal dominantly disorder. DM1, also called Steinert characterized by myotonia, muscle weakness, muscular dystrophy, endocrinopathy, cataract, cardiac conduction defect, central nervous system (CNS) dysfunction, so on. The symptoms of CNS abnormalities mainly include impaired motor function, cognitive...

10.4103/0366-6999.156812 article EN cc-by-nc-nd Chinese Medical Journal 2015-05-11

Intracranial atherosclerotic stenosis is one of the main causes ischemic stroke and transient attack. High-resolution magnetic resonance imaging allows us to directly observe intracranial artery wall, accurately assess condition vascular quantitatively analyze wall plaque load. We report a case acute cerebral infarction with left middle stenosis. During first 3 weeks, patient was treated aspirin 100 mg clopidogrel 75 daily. Afterwards, continued be given aspirin, cilostazol twice daily...

10.3389/fnagi.2022.804074 article EN cc-by Frontiers in Aging Neuroscience 2022-04-27

To explore the correlation between cerebrovascular hemodynamic index (CVHI)accumulative score and subclinical arteriosclerosis indicators. Methods: A total of 27 184 cases were collected from Health Management Center, Third Xiangya Hospital, Central South University. Linear regression analysis was carried out to confirm correlations CVHI accumulative modified Framingham stroke profile (FSP), as well diseases (ICVD) scale. The brachial-ankle pulse wave velocity (baPWV), carotid plaque...

10.11817/j.issn.1672-7347.2018.02.016 article EN PubMed 2018-02-28

10.3760/cma.j.issn.1001-4497.2016.03.017 article EN Chinese Journal of Thoracic and Cardiovaescular Surgery 2016-03-25

Objective To analyze the risk factors for formation of carotid atherosclerotic plaque. Methods The clinical data 279 hospitalized patients undergoing artery color Doppler ultrasonography between June 2005 and December 2006 were collected. Multiple regression common intimal-medial thickness (IMT) was used to screen potential plaque formation. divided into two groups according presence plaque, binary logistic univariate analysis identify factors. score index compared subgroups with different...

10.3760/cma.j.issn.1671-8925.2008.11.022 article EN Chinese Journal of Neuromedicine 2008-11-15

Objective: Background: Data from animal studies showed that the artery occlusion supplying brainstem caused a significantly greater increase in sympathetic nerve activity and mean arterial pressure. To gain support for this hypothesis human, We postulate level of blood pressure patients with posterior circulation hypoperfusion by significant stenosis proximal subclavian or vertebral arteries may reduced after successfully stenting lesions. evaluate effect on hypertensive symptomatic...

10.1097/01.hjh.0000539332.87313.96 article EN Journal of Hypertension 2018-06-01
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