Abstract Background In keeping with nation-wide efforts to contain the spread of COVID-19, Universiti Brunei Darussalam (UBD) transformed fully its pedagogical delivery online mode, where we investigated teaching and learning experiences, physical mental health undergraduate students lecturers during COVID-19 pandemic. Methods We conducted a cross-sectional study on in science faculty using self-developed pretested questionnaire through anonymous data collection method. Results Fifty-six...

This literature review aims to update the current knowledge on toxicity of chitosan nanoparticles, compare recent findings and identify gaps with that is present for nanoparticles.

The goal of this study was to formulate and evaluate side effects transdermal delivery proniosomal gel compared oral tolterodine tartrate (TT) for the treatment overactive bladder (OAB). Proniosomal gels are surfactants, lipids soy lecithin, prepared by coacervation phase separation. Formulations were analyzed drug entrapment efficiency (EE), vesicle size, surface morphology, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, in vitro skin permeation, vivo...

Modern medicinal plant drug discovery has provided pharmacologically active compounds targeted against a multitude of conditions and diseases, such as infection, inflammation, cancer. To date, natural products from plants remain solid niche source which cancer therapies can be derived. Among other properties, one favorable characteristic an anticancer is its ability to block the uncontrollable process cell division, cells are notorious for their abnormal division. There numerous documented...

Abstract The present work examined the effect of oral administration rutin and its combination with metformin, an antidiabetic drug on blood glucose, total cholesterol triglycerides level vascular function in streptozotocin (STZ) -induced diabetic rats. Male Sprague Dawley rats were rendered by a single intraperitoneal injection STZ (50 mg/kg). Rutin metformin orally administered to at dose 100 mg/kg 300 body weight/day, respectively, for 4 weeks. Plasma analysis was conducted determine...

Purpose: To develop and evaluate self-adhesive matrix-type ondansetron hydrochloride (OND) transdermal formulation.Methods: OND patches were prepared using solvent casting method. The matrix polymer composition was Eudragit E 100, polyvinyl pyrrolidone either propylene glycol or dibutyl sebacate as plasticizer. Mean patch thickness, tensile strength, moisture content, water absorption capacity drug content of the studied. In vitro release permeation determined Franz diffusion cell.Results:...

Introduction: The use of liquid crystalline (LC) gel formulations for drug delivery has considerably improved the current methods in terms bioavailability and efficacy. purpose this study was to develop evaluate LC deliver anti-cancer exemestane through transdermal route. Methods: Two were prepared by phase separation coacervation method using glyceryl monooleate (GMO), Tween 80 Pluronic® F127 (F127). characterized with regard encapsulation efficiency (EE), vesicle size, Fourier transform...

According to the World Health Organization (WHO), diabetes has been increasing steadily over past few decades. In developing countries, it is cause of increased morbidity and mortality. Diabetes its complications are associated with education, occupation, income across all levels socioeconomic status. Factors, such as hyperglycemia, social ignorance, lack proper health knowledge, late access medical care, can worsen diabetic complications. Amongst complications, neuropathic pain inflammation...

Overactive bladder (OAB) is a common problem and anticholinergic drugs are first-line therapy, but they have side effects.Development of oxybutynin chloride (OC) proniosomal gels analyses its efficacy for OAB treatment.Phase separation coacervation was used to prepare using various non-ionic surfactants, lipids, soy lecithin isopropyl alcohol. Gels were characterized with regard entrapment efficiency (EE), vesicle size, surface morphology (using environmental scanning electron microscopy...

Curcumin is a hydrophobic compound with good anti-proliferative, anti-oxidative, and anti-cancer properties but has poor bioavailability. Liquid crystals (LC) can accommodate both hydrophilic drugs. The aim of this study was to formulate evaluate novel vaginal drug delivery system for cervical cancer using curcumin LC system. formulated surfactant, glycerol, water together curcumin. Three types surfactants were used optimize the formulation, i.e., Tween 80, Cremphor EL, Labrasol. optimized...

OBJECTIVES: The aim of the present investigation was to form matrix patches with ethyl cellulose (EC) as base polymer, polyvinyl pyrrolidone (PVP) copolymer, plasticizer dibutyl phthalate (DBP) or acetyl tributyl citrate (ATBC) and drug glipizide (gz) by solvent casting method. Physicochemical properties in vitro release were determined a modified Keshary-chien diffusion cell optimize patch formulations help experimental data figures for further studies. TECHNIQUES: EC PVP different...

Background: Peritonitis is the most serious complication of peritoneal dialysis. Staphylococcus aureus infections could lead to peritonitis which causes reversal dialysis treatment back hemodialysis. The aim this study was develop a controlled release silicone adhesive-based mupirocin patch for prophylactic effect and analyze its antibacterial effectiveness against S. . Methods: matrix patches were prepared by using different polymers, with without adhesive, dibutyl sebacate mupirocin....

<title>Abstract</title> Guided tissue regeneration (GTR) is a method for separating proliferating soft from bone tissue. However, various factors may cause GTR membrane failure. This study aimed to prepare chitosan-polyvinyl alcohol (CS-PVA) composite membranes with and without glutaraldehyde crosslinking drug loading GTR. We characterized the mechanical physiochemical properties of membranes, including swelling, water vapor permeability, attenuated total reflectance-Fourier transform...

Melastoma malabathricum (MM) is a traditional plant used in the Borneo region. The cytotoxic effects of methanol extracts from MM leaves have been reported number human cancer cell lines. However, mode death by has not investigated.We investigated both breast and lung lines, MCF-7 A549, respectively, defined death.Cell viability was measured using 3-(4-, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Annexin-V/propidium iodide (PI) terminal deoxynucleotidyl transferase...