A5074217967- Advancements in Transdermal Drug Delivery
- Innovations in Medical Education
- Problem and Project Based Learning
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Antioxidant Activity and Oxidative Stress
- Sperm and Testicular Function
- Urinary Bladder and Prostate Research
- Proteins in Food Systems
- Education and Critical Thinking Development
- Prostate Cancer Treatment and Research
- Drug-Induced Hepatotoxicity and Protection
- Diamond and Carbon-based Materials Research
- Phytochemical compounds biological activities
- Morinda citrifolia extract uses
- Pelvic floor disorders treatments
- Urologic and reproductive health conditions
- Medicinal Plant Research
- Diet, Metabolism, and Disease
- Antifungal resistance and susceptibility
- Polysaccharides Composition and Applications
- Angiogenesis and VEGF in Cancer
- Ginger and Zingiberaceae research
SEGi University
2015-2024
International Medical University
2007-2023
Mahsa University
2020-2023
Bharath University
2023
Universiti Brunei Darussalam
2023
Wyoming Department of Education
2023
University of Wyoming
2023
Perdana University
2013-2020
Indian Institute of Technology Madras
2006-2017
Asia e University
2015
Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective this study was to extract and further characterize tamarind gum polysaccharide (TGP) obtained Tamarindus indica an excipient for biomedical applications. Double distilled water a solvent extraction while Ethyl alcohol antisolvent precipitation. results Hausner ratio, Carr’s index angle repose were found be 0.94, 6.25, 0.14, respectively, which revealed that powder is...
Etlingera elatior or 'pink torch ginger' (Zingiberaceae) are widely cultivated in tropical countries and used as spices food flavoring. The purpose of this study was to evaluate the antioxidant effects against lead - induced changes serum free radical scavenging enzymes lipid hydroperoxides rats. Rats were exposed acetate drinking water (500 ppm) for 14 days alone plus ethanol extract E. (50, 100 200 mg/kg). Blood levels, hydroperoxides, protein carbonyl contents oxidative marker estimated....
Purpose: The present study was intended to fabricate chitosan (Ch)-tamarind gum polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin and evaluate their potential against human breast cancer cell lines. Materials Methods: antisolvent precipitation method used for formulation nanoparticles. Factorial design (3 2 ) utilized as a tool analyze the effect Ch TGP concentration on particle size entrapment efficiency Results: Formulated showed high (67.19± 0.42–...
Abstract Haloperidol is an antipsychotic drug that exerts its' effects by inhibiting dopaminergic neurons. Although the exact pathophysiology of haloperidol extrapyramidal symptoms are not known, role reactive oxygen species in inducing oxidative stress has been proposed as one mechanisms prolonged haloperidol-induced neurotoxicity. In present study, we evaluate protective effect alpha lipoic acid against rat brain. Sprague Dawley rats were divided into control, alone (100 mg/kg p.o for 21...
Abstract Background Sunitinib, a tyrosine kinase inhibitor to treat GIST and mRCC may interact with paracetamol as both undergo P450 mediated biotransformation P-glycoprotein transport. This study evaluates the effects of sunitinib-paracetamol coadministration on liver renal function biomarkers liver, kidney, brain, heart spleen histopathology. ICR male mice (n = 6 per group/dose) were administered saline (group-A) or 500 mg/kg IP (group-B), sunitinib at 25, 50, 80, 100, 140 PO (group-C)...
Lead is known to disrupt the biological systems by altering molecular interactions, cell signaling, and cellular function. Exposure even low levels of lead may have potential hazardous effects on brain, liver, kidneys testes. The efficacy Etlingera elatior (torch ginger) protect hepatotoxicity induced acetate was evaluated experimentally in male Sprague - Dawley rats. Rats were exposed drinking water (500 ppm) for 21 days concurrent treatment with extract E. hepatic lipid hydroperoxides...
Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro and recently recognised for its therapeutic potential metabolic syndrome. This study investigated antioxidative strength protective effects on organs high-fat diet-induced (HFD) rodents. Rats were fed HFD six weeks induce obesity, followed by 10 mg/kg 50 of geraniin supplementation four assess potential. The control groups maintained standard...
The main objective of the study was to prepare tamarind seed polysaccharide grafted copolymers polyacrylamide (TSP-g-Am) using a 3
The aim of the present study was to look into possible protective effects glycyrrhizic acid (GA) against isoproterenol-induced acute myocardial infarction in Sprague-Dawley rats. effect three doses response isoproterenol (ISO)-induced changes 8-isoprostane, lipid hydroperoxides, super oxide dismutase and total glutathione were evaluated. Male rats divided control, ISO-control, alone (in doses-5, 10 20 mg/kg BW) ISO with doses) groups. administered at 85 BW two consecutive days...
In this study, the acute and subchronic toxicity effect of Syzygium aqueum leaf extract (SA) was evaluated. For a single dose 2000 mg/kg SA given by oral-gavage to male Sprague-Dawley (SD) rats. The rats were observed for mortality signs 14 days. study administered orally at doses 50, 100, 200 per day 28 days SD animals sacrificed end experiment. parameters measured including food water intake, body weight, absolute relative organ blood biochemical tests histopathology observation. both...
The goal of this study was to formulate and evaluate side effects transdermal delivery proniosomal gel compared oral tolterodine tartrate (TT) for the treatment overactive bladder (OAB). Proniosomal gels are surfactants, lipids soy lecithin, prepared by coacervation phase separation. Formulations were analyzed drug entrapment efficiency (EE), vesicle size, surface morphology, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, in vitro skin permeation, vivo...
Oral tamoxifen used in the prevention and treatment of ductal carcinoma situ (DCIS) (estrogen-positive) patients has limited acceptance, due to its adverse side effects. The efficacy is related major metabolite, 4-hydroxytamoxifen. Local transdermal therapy 4-hydroxytamoxifen breast might avert toxicity oral tamoxifen, while maintaining efficacy. We aim study skin irritancy, as well evaluate developed transfersome formulations, with/without emu oil, using a syngeneic mouse model cancer. also...
Diabetes mellitus or type-2 diabetes, commonly referred as is a metabolic disorder that results in high blood sugar level. Despite the availability of several antidiabetic drugs market, they still do not adequately regulate levels. Thus, general people prefer to use herbal supplements/medicines along with control One such medicine Swietenia macrophylla seeds. It widely used Asia for controlling major bioactive compounds, Swietenine, reported be responsible glucose However, there were no...
Tocotrienols exhibit a significant anti‑inflammatory and antioxidant effect in numerous human diseases. However, the effects of tocotrienols arthritic conditions are not well documented. Therefore, γ‑tocotrienol supplementation against oxidative stress joint pathology collagen-induced arthritis rats was investigated present study. Adult female Dark Agouti were randomly divided into groups: Control, alone, alone with γ‑tocotrienol. Arthritis induced using 4 mg/kg body weight collagen complete...
Angiogenesis has been reported to be one of the contributory factors pathogenesis psoriasis vulgaris. This study aims compare expression different angiogenesis growth namely (1) vascular endothelial factor (VEGF) subfamily: A, B, C, D and placenta (PlGF); (2) nerve (NGF) (3) von Willebrand (vWFr) in skins patients with vulgaris non-psoriatic volunteers.Comparative immunohistochemistry was performed on paraffin-sectioned psoriatic healthy abovementioned markers. VEGF-C (p = 0.016) NGF 0.027)...
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease primarily involving inflammation of the joints. Although management has advanced significantly in past three decades, there still no cure for RA. The aim this study was to determine therapeutic efficacy δ -tocotrienol, rat model collagen-induced (CIA). Arthritis induced by intradermal injection collagen type II emulsified complete Freund’s adjuvant. CIA rats were orally treated with -tocotrienol (10 mg/kg) or glucosamine...
Nutrition can modulate host immune responses as well promote anticancer effects. In this study, two nutritional supplements, namely gamma-tocotrienol (γT3) and Spirulina, were evaluated for their immune-enhancing effects in a syngeneic mouse model of breast cancer (BC). Five-week-old female BALB/c mice fed γT3, or combination Spirulina γT3 (Spirulina + γT3) 56 days. The inoculated with 4T1 cells into mammary fat pad on day 28 to induce BC. animals culled various analyses. A significant...