A5001331223- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Immunotherapy and Immune Responses
- Health and Medical Studies
- Immune Response and Inflammation
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Hepatitis B Virus Studies
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Myeloid Leukemia Research
- Health Promotion and Cardiovascular Prevention
- Peripheral Neuropathies and Disorders
- Pediatric health and respiratory diseases
- Smoking Behavior and Cessation
- Child and Adolescent Health
- Gut microbiota and health
- Infant Health and Development
- Chronic Lymphocytic Leukemia Research
- Vaccine Coverage and Hesitancy
- Immunodeficiency and Autoimmune Disorders
- Inflammatory Bowel Disease
- Virology and Viral Diseases
Johannes Gutenberg University Mainz
2013-2024
University Medical Center of the Johannes Gutenberg University Mainz
2002-2022
Hôpital Émile-Roux
2020
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace
2020
Bicêtre Hospital
2019
Goethe University Frankfurt
2010-2014
Robert Koch Institute
2002-2010
Heidelberg University
2009-2010
Sana Klinikum Offenbach
2010
University Hospital Heidelberg
2009
We have reported that cordycepin, an adenosine derivative from the fungus Cordyceps, increased interleukin (IL)-10 expression, decreased IL-2 expression and suppressed T lymphocyte activity. In present study, we further characterized regulatory effects of cordycepin on human immune cells. Moreover, a traditional Chinese drug, Cordyceps sinensis (CS) contains was also investigated. Cytometric Bead Array (CBA) used to determine concentrations IL-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10,...
Current treatment for pediatric inflammatory bowel disease (IBD) patients is often ineffective, with serious side effects. Manipulating the gut microbiota via fecal transplantation (FMT) an emerging approach but remains controversial. We aimed to assess composition of microbiome through a comparison IBD their healthy siblings, evaluating risks and prospects FMT in this setting. A case-control (sibling) study was conducted analyzing samples six children Crohn's (CD), ulcerative colitis (UC)...
Importance The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified. Objective To examine the efficacy Bifidobacterium longum subsp infantis , animalis lactis (BB-12), Lactobacillus acidophilus (La-5) probiotics prevent multidrug-resistant organisms or highly epidemic (MDRO+) shape toward eubiotic state healthy full-term infants. Design, Setting, Participants multicenter, double-blinded,...
Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp299Gly and Thr399Ile) meningococcal disease in 197 patients 214 healthy controls by allele-specific real time polymerase chain reaction direct sequencing. Although the allele frequency was not higher overall patient population, a significantly 40 younger than 12 months age (P = 0.007) observed. conclude that represent risk factor this group.
Pathogen reduction (PR) systems for platelets, based on chemically induced cross-linking and inactivation of nucleic acids, potentially prevent transfusion transmission infectious agents, but can increase clinically significant bleeding in some clinical studies. Here, we documented the effects PR microRNA mRNA levels platelets stored blood bank, assessed their impact platelet activation function. Unlike subjected to gamma irradiation or additive solution, treated with Intercept (amotosalen+...
Meconium constitutes infants' first bowel movements postnatally. The consistency and microbial load of meconium are different from infant adult stool. While recent evidence suggests that is sterile in utero, rapid colonization occurs after birth. microbiome has been associated with negative health outcomes, but its composition not well described, especially preterm infants. Here, we characterized the microbiomes 330 very infants (gestational ages 28 to 32 weeks) 15 hospitals Germany fecal...
Mannose-binding lectin (MBL) is an important factor of the innate immune system, and MBL-initiated complement activation early defense mechanism against various bacterial infections, including invasive meningococcal disease.In a pediatric cohort (ages 2-215 months) with disease, we investigated overall age-stratified frequency 3 MBL exon 1 variations (C154T, G161A, G170A), previously shown to result in markedly decreased plasma concentrations, by allele specific fluorescent hybridization...
Zostavax(®) is a live, attenuated varicella zoster virus (VZV) vaccine developed specifically for the prevention of HZ and PHN in individuals aged ≥50 years. During clinical development Zostavax, which was mainly US, administrated by subcutaneous (SC) route. In Europe, many healthcare professionals prefer administering vaccines intramuscular (IM) This an open-label, randomised trial conducted 354 subjects The primary objectives were to demonstrate that IM administration both non-inferior SC...
The healthy 'eubiosis' microbiome in infancy is regarded as the derived from term, vaginally delivered, antibiotic free, breastfed infants at 4-6 months. Dysbiosis a deviation state with reduced microbial diversity and deficient capacity to control drug-resistant organisms. Preterm are highly sensitive early gut dysbiosis. Latter has been associated sepsis necrotising enterocolitis, but may also contribute long-term health problems. Probiotics hold promise reduce risk for adverse short-term...
Research Article4 October 2013Open Access Instruction of haematopoietic lineage choices, evolution transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model Nina Cabezas-Wallscheid Medical Center the Johannes Gutenberg-University Mainz, Department Internal Medicine III, Division Translational Experimental Oncology, Germany German Cancer Center, Stem Cells Cancer, Heidelberg, Institute for Toxicology, Search more papers by this author Victoria Eichwald...
On 16 February 2005, the Deutsche Stiftung Organtransplantation (German Foundation for Organ Transplantation, http://www.dso.de/) announced possible rabies cases in three of six patients who received organs from a donor died late December 2004
ABSTRACT Cell-mediated immune (CMI) responses to an acellular pertussis vaccine administered 49 subjects, a subset of participants in the National Institutes Health-funded adult efficacy trial, were evaluated and compared with antibody antigens. Levels proliferation cytokine secretion from lymphocytes cultured presence toxin, filamentous hemagglutinin, or pertactin measured before vaccination 1 month year after vaccination. Statistically significant increases lymphocyte stimulation indices...