A5008184037- Ovarian cancer diagnosis and treatment
- Bacterial Infections and Vaccines
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Bacterial Genetics and Biotechnology
- Pneumonia and Respiratory Infections
- Cancer Treatment and Pharmacology
- Palliative Care and End-of-Life Issues
- Escherichia coli research studies
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Cancer, Lipids, and Metabolism
- Nausea and vomiting management
- Antibiotic Resistance in Bacteria
- COVID-19 and healthcare impacts
- Cancer survivorship and care
- Pharmaceutical studies and practices
- RNA and protein synthesis mechanisms
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Reproductive System and Pregnancy
- COVID-19 and Mental Health
University of Verona
2021
Regione del Veneto
2018-2020
Novartis (Italy)
2009-2011
Newron Pharmaceuticals (Italy)
2009
Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation bacterial populations to changing environments and is frequently important virulence. Here we elucidate a novel phase mechanism for NadA, an adhesin invasin Neisseria meningitidis. The NadR repressor protein binds operators flanking tract contributes differential expression levels variant promoters with different numbers repeats likely due spacing between...
Neisseria meningitidis is a major cause of septicemia and meningitis. The hypervirulent clonal complex 41/44 (cc41/44) has emerged as the predominant serogroup B meningococcal disease, having been responsible for recent outbreaks epidemics worldwide. However, factors that enable transition from asymptomatic carriage to rapidly progressing disease are poorly understood. Here we describe novel phase-variable DNA methyltransferase, ModD, which was identified in genome sequence New Zealand...
The psychological impact of the Covid 19 pandemic on cancer patients, a population at higher risk fatal consequences if infected, has been only rarely evaluated. This study was conducted Departments Oncology four hospitals located in Verona area Italy to investigate patients under active anticancer treatments. A 13-item ad hoc questionnaire evaluate status before and during administered 474 consecutive subjects time frame between April 27 th June 7 2020. Among 13 questions, were considered...
Abstract Neutrophil-to-lymphocyte ratio (NLR) and systemic inflammatory index (SII) are prognostic factors in epithelial ovarian cancer (EOC). Their predictive value for platinum-sensitivity their role recurrent EOC unknown. A total of 375 patients were retrospectively analyzed. The correlation between baseline NLR SII, platinum-free interval (PFI) according to first line bevacizumab treatment analyzed using logistic regression analyses adjusted patient characteristics. Subsequently SII...
Background: Immune checkpoint inhibitors (ICI) plus radiotherapy (RT) have been suggested as an emerging combination in non-small cell lung cancer (NSCLC) patients. However, little is known about the magnitude of its benefits and potential clinical predictors. Objective: To assess effects this on increase overall progression-free survival. Data sources: The MEDLINE CANCERLIT (1970–2020) electronic databases were searched, reference lists included studies manually searched. Study selection:...
The Neisseria meningitidis regulator NadR was shown to repress expression of the NadA adhesin and play a major role in phase-variable expression. In this study, we identified through microarray analysis over 30 genes coregulated with nadA mutant defined members regulon vitro DNA-binding assays. Two distinct types promoter architectures (I II) were for targets, differing both number position NadR-binding sites. All NadR-regulated investigated found respond 4-hydroxyphenylacetic acid (4HPA),...