A5031187970- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Gestational Trophoblastic Disease Studies
- Uterine Myomas and Treatments
- Ovarian function and disorders
- Pancreatitis Pathology and Treatment
- Genetic and Kidney Cyst Diseases
- Prenatal Screening and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Renal Diseases and Glomerulopathies
- Gynecological conditions and treatments
- Reproductive Biology and Fertility
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Renal cell carcinoma treatment
- Nail Diseases and Treatments
- Nausea and vomiting management
- Liver Disease Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Diverticular Disease and Complications
IRCCS Ospedale San Raffaele
1997-2024
Vita-Salute San Raffaele University
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2017-2024
San Raffaele University of Rome
2018-2020
This review navigates the intricate relationship between gender, hormonal influences, and progression of autosomal dominant polycystic kidney disease (ADPKD), highlighting limited literature on this crucial topic. The study explores impact female sex hormones liver renal manifestations, uncovering gender-specific differences in progression. Actually, therapy women with ADPKD remains a challenging issue is source concern regarding its potential outcomes, particularly at hepatic level....
ADPKD is the most common inherited kidney disorder, marked by numerous renal cysts, increased total volume and progressive function decline. Mutations in PKD1 PKD2 genes, leading to altered cAMP signaling, drive cyst growth. Elevated antidiuretic hormone (ADH) levels further exacerbate cystogenesis. Tolvaptan, a vasopressin V2 receptor antagonist, only approved treatment for slowing progression, but its use often results significant polyuria thirst, affecting patient quality of life. This...
Background: Chemotherapy is the treatment of choice for many gynecological tumors, but cytotoxic drugs lead to a wide range stressful side effects; nausea and vomiting are 2 most common distressing consequences chemotherapy regimens. Objective: The aim this study investigate various risk factors that could influence experience after first chemotherapeutic infusion. Methods: Women treated cancers (n = 94) took part in study. Pharmacological personal development chemotherapy-induced (CINV)...
<h3>Objectives</h3> Gestational trophoblastic neoplasia affects women of reproductive age and is usually treated by chemotherapy. Major concerns related to chemotherapy in young are the possible infertility, risk early menopause, teratogenic effects on subsequent pregnancies. The study9s aim was analyze menstrual outcomes with single-agent versus multiagent for gestational neoplasia. <h3>Methods</h3> One-hundred fifty-one patients were treated. Seventy-six older than 45 years, a placental...
Women older than 40 years develop gestational trophoblastic neoplasia (GTN) after a hydatidiform mole (HM) more often do younger women. Therefore, in elderly women, primary hysterectomy has been advocated as first-line treatment. The aim of the present study was to evaluate whether could reduce incidence GTN diagnosis HM.Seventy-six 442 patients referred our unit for an HM between 1994 and 2015 were old. Among these, 12 treated by hysterectomy. We compared clinical features, serum human...
To review a single-center clinical experience with neoadjuvant chemotherapy (NACT) in population of frail epithelial ovarian cancer (EOC) patients and investigate the prognostic role advanced age.We retrospectively reviewed data from 102 EOC treated NACT presenting high perioperative risk. Patients were divided into 2 groups: group A, including aged 70 years or older; B, below old. Univariate multivariate analyses performed to compare survival factors for between two groups.Forty-two (41.2%)...
Background The aim of the present study is to explore correlation between PET and MRI parameters primary tumour clinicopathological features determine their synergic predictive role in patients with endometrial cancer candidate surgery. Methods Retrospective including 27 preoperative 18F-fluorodeoxyglucose (18F-FDG)-PET scan. following parameters, calculated on tumour, were used for analysis: maximum standardized uptake value (SUVmax), SUVmean, metabolic volume (MTV) total lesion glycolysis...
About 2.7% of patients epithelial ovarian cancers (EOC) are younger than 40 and present with stage I disease. For this subset women, the issue fertility sparing surgery (FSS) has become critical. The aim survey was to investigate management EOC desiring preserve in Italy. A questionnaire consisting 30 items developed evaluate: patient-selection criteria, rate FSS, patient's counseling- pregnancy-timing, preservation, obstetrics, oncologic outcomes. One expert clinician for each 50 major...
<h3>Objective</h3> Ultrasound features of granulosa cell tumors the ovary are still poorly defined. The aim this study is to widen current knowledge on role sonographic gray scale and pattern recognition in characterization these compare ultrasound characteristics primary diagnosis recurrences. <h3>Methods</h3> Transvaginal images or recurrences histologically-confirmed were retrospectively retrieved from a dedicated database designed for collection clinical data January 2001 2019. All...
The prolonged, gonadotoxic effect of chemotherapy can finally lead to infertility in female cancer survivors. There is controversial evidence regarding the protective role gonadotropin-releasing hormone analogue (GnRH-a) on chemotherapy-induced ovarian damage. In present study a murine model, ultrasound (US) and contrast-enhanced US (CEUS) were firstly used characterise glands normal conditions validate preclinical model. addition, preliminary findings obtained anatomical vascular changes...
Gestational trophoblastic disease (GTD) is a spectrum of disorders originating from the placenta, including premalignant forms, such as complete and partial hydatidiform mole, malignant invasive choriocarcinoma, placental site tumor epithelioid tumor.The incidence GTD varies between countries prevalence depends on maternal age, previous history, socioeconomic factors.Histology molecular genetic studies can help in diagnostic pathway.Diagnosis based multifactorial approach consisting clinical...